Intoxication par ingestion de foie de sériole de Méditerranée : tableau clinique d’une hypervitaminose A

Hypervitaminosis A Following the Ingestion of Fish Liver: Report on 3 Cases from the Poison Control Center in Marseille

“…Five cases of hypervitaminosis A have already been reported to the PCCM after ingestion of tuna, amberjack, and grouper liver but with no biological confirmation. 5,14 The few cases of poisoning from fish liver with available retinol blood levels were consistent with the results of Patient 2 (between 4.94 and 6.20 mmol$L -1 ). 6,10,11 However, blood retinol levels are not the best markers for vitamin A levels.…”

“…1,11 Treatment is mainly supportive using analgesics, fluids by infusion, and medical monitoring for signs of raised intracranial pressure because functional neurological prognosis may be at stake. 5,6,9 Anamnesis, the clinical picture, and the collective nature of food poisoning leaves little doubt as to the diagnosis of the first 2 cases. Furthermore, the blood test carried out for Patient 2 confirmed the excessive level of retinol.…”

“…Native inhabitants of the polar regions are aware of this risk and are careful about the amounts of liver they eat from the polar bears or seals they hunt. [4][5][6] In some Asian cultures, fish liver is eaten frequently, and cases of poisoning in these regions have been reported within the last few years after ingestion of red snapper, grouper, seerfish, or wreckfish. 5,[7][8][9][10][11] Fish liver is also eaten in mainland and overseas France, sometimes leading to toxicity, as is illustrated in these cases attended through telephone calls by toxicologists at the poison control center in Marseille (PCCM).…”

“…[4][5][6] In some Asian cultures, fish liver is eaten frequently, and cases of poisoning in these regions have been reported within the last few years after ingestion of red snapper, grouper, seerfish, or wreckfish. 5,[7][8][9][10][11] Fish liver is also eaten in mainland and overseas France, sometimes leading to toxicity, as is illustrated in these cases attended through telephone calls by toxicologists at the poison control center in Marseille (PCCM). All of these cases took place within the area under the PCCM's responsibility (ie, Southeast France and French territories in the Indian Ocean).…”

“…Native inhabitants of the polar regions are aware of this risk and are careful about the amounts of liver they eat from the polar bears or seals they hunt. 4 -6 In some Asian cultures, fish liver is eaten frequently, and cases of poisoning in these regions have been reported within the last few years after ingestion of red snapper, grouper, seerfish, or wreckfish. 5,7 -11…”