Intoxication aiguë et chronique au cadmium

Andujar, Pascal; Bensefa‐Colas, Lynda; Descatha, Alexis

doi:10.1016/j.revmed.2009.02.029

Cited by 37 publications

(18 citation statements)

References 42 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been noted that higher levels of cadmium exposure can exceed the production capacity of MT in the renal tubular cytoplasm leading to free cadmium. 24 The effects of cadmium on the liver may be through a similar mechanism of cadmium levels exceeding hepatic MT production. In mouse models of chronic cadmium exposure induced hepatotoxicity, inflammation and apoptosis of hepatocytes have been noted in both wild-type (mice with intact MT) and MT-null mice, but were more pronounced in the latter.…”

Section: Discussionmentioning

confidence: 99%

Cadmium Exposure and Liver Disease among US Adults

Hyder

Chung

Cosgrove

et al. 2013

Journal of Gastrointestinal Surgery

226

138

View full text Add to dashboard Cite

Background Effects of chronic cadmium exposure on liver disease and liver-related mortality are unknown. We evaluated the association of creatinine-corrected urinary cadmium levels with hepatic necroinflammation, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), liver-related mortality, and liver cancer mortality in the US general population. Methods We analyzed the relationship of individuals in the top quartile for urinary cadmium measured in 12,732 adults who participated in the Third National Health and Nutrition Examination Survey in 1988–1994 (NHANES III), and hepatic necroinflammation, NAFLD, and NASH. Associations between cadmium, liver-related mortality, and liver cancer mortality were evaluated in the NHANES III mortality follow-up study. Results The cutoffs for highest quartile of urinary cadmium per gram of urinary creatinine were 0.65 and 0.83 μg/g for men and women, respectively (P<0.001). After multivariate adjustment for other factors including smoking, the odds ratios [95 % confidence intervals (CI)] for hepatic necroinflammation, NAFLD, and NASH associated with being in the top quartile of cadmium levels by gender, were 2.21 (95 % CI, 1.64–3.00), 1.30 (95 % CI, 1.01–1.68) and 1.95 (95 % CI, 1.11–3.41) for men and 1.26 (95 % CI, 1.01–1.57), 1.11 (95 % CI, 0.88–1.41) and 1.34 (95 % CI, 0.72–2.50) for women, respectively. The hazard ratios for liver-related mortality and liver cancer mortality for both genders were 3.42 (95 % CI, 1.12–10.47) and 1.25 (95 % CI, 0.37–4.27). Conclusions Environmental cadmium exposure was associated with hepatic necroinflammation, NAFLD, and NASH in men, and hepatic necroinflammation in women. Individuals in the top quartile of creatinine-corrected urinary cadmium had over a threefold increased risk of liver disease mortality but not in liver cancer related mortality.

show abstract

Section: Discussionmentioning

confidence: 99%

Cadmium Exposure and Liver Disease among US Adults

Hyder

Chung

Cosgrove

et al. 2013

Journal of Gastrointestinal Surgery

226

138

View full text Add to dashboard Cite

show abstract

“…Cd is a very toxic environmental pollutant that causes the production of reactive oxygen species (ROS), such as superoxide anions, hydrogen peroxide, hydroxyl radicals and NO, 1,25,26 thus impairing the balance between prooxidant and antioxidant systems. [27][28][29] In the present study, oxidative stress was found to be induced in the liver during acute co-exposure to ethanol and Cd.…”

Section: Discussionmentioning

confidence: 99%

“…1 The initial site of its accumulation is liver; hence, acute exposure to large Cd doses re-160 RADOSAVLJEVIĆ et al sults in liver injury. Morphologic changes in the liver that follow acute Cd exposition depend on the administered dose and on time when these changes are observed and may vary from dilation of the rough endoplasmic reticulum with loss of ribosomes to hepatocellular necrosis, becoming evident 10-12 h after exposure.…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress in rat liver during acute cadmium and ethanol intoxication

Radosavljević¹,

Mladenović²,

Ninković³

et al. 2012

JSCS

View full text Add to dashboard Cite

The aim of our study was to investigate the effects of binge drinking on prooxidant/antioxidant system in rat liver in acute cadmium (Cd) intoxication. In experiment male Wistar rats were used and divided into following groups: 1. control, 2. ethanol-treated group, in five subsequent doses of 2 g/kg administered by orogastric tube, 3. Cd-treated group in a single dose of 2.5 mg/kg intraperitoneally, 4. group that received Cd 12 hours after the last dose of ethanol. Blood and liver samples were collected for determination of oxidative stress parameters, 24 hours after treatment. When administered in combination, ethanol and Cd induced a more pronounced increase in serum and liver malondialdehyde level than either of these substances alone (p<0.01). Liver manganese superoxide dismutase (MnSOD) activity was increased both in ethanol and Cd-treated group (p<0.01), while liver copper/zinc superoxide dismutase (Cu/ZnSOD) activity was elevated in Cd group only. However, when administered in combination, ethanol and Cd induced a more pronounced decrease in liver MnSOD and Cu/ZnSOD activity 24 hours after treatment (p<0.01). Based on our study, it can be concluded that ethanol may act sinergistically with Cd in inducing lipid peroxidation and reduction in liver SOD activity

show abstract

“…In acute exposure, inhalation of cadmium oxide fumes may induce inhalation fever or chemical pneumonitis [41] . In chronic exposure, cadmium poisoning may cause renal tubulopathy, induce osteomalacia, and diffuse osteoporosis [41].…”

Section: Discussionmentioning

confidence: 99%

Association between blood cadmium levels and malnutrition in peritoneal dialysis

et al. 2014

View full text Add to dashboard Cite

BackgroundMalnutrition is associated with an increased risk of cardiovascular death and may cause protein-energy wasting in individuals with chronic kidney disease. A previous study demonstrated that blood cadmium levels (BCLs) were associated with malnutrition in maintenance hemodialysis (MHD) patients. However, the correlation between cadmium exposure and malnutrition remains unclear in chronic peritoneal dialysis (CPD) patients. This study examined the possible adverse effects of environmental cadmium exposure in CPD patients.MethodsA total of 301 CPD patients were enrolled and divided into 3 study groups based on the following BCL tertiles: low (<0.19 μg/L), middle (0.19–0.39 μg/L), and high (>0.39 μg/L). Demographic, hematological, biochemical, and dialysis-related data were obtained for analysis. The analysis also included values of nutritional and inflammatory markers.ResultsThe BCLs of CPD patients were lower than those of MHD patients. At baseline, patients in the high BCL group were older and had a higher prevalence of diabetes mellitus but lower serum albumin, creatinine, and phosphate levels than the patients in the other 2 groups. After adjusting for potential variables, stepwise backward multiple linear regression analysis revealed that age and alanine aminotransferase levels were positively associated with logarithmic transformation of BCLs (log BCLs), while serum albumin levels were negatively associated with log BCLs in CPD patients. The log BCLs were a significant determinant (beta coefficient ± standard error = -0.185 ± 0.074; P = 0.013) of nutritional status and significantly associated with the presence of malnutrition (odds ratio = 2.64; 95% confidence interval: 1.07–6.48; P = 0.035) in CPD patients after adjustment for related variables.ConclusionsBCL is significantly associated with nutritional status and malnutrition in CPD patients. Therefore, it is important for CPD patients to avoid environmental exposure to cadmium such as through smoking and consumption of cadmium-rich foods.

show abstract

Intoxication aiguë et chronique au cadmium

Cited by 37 publications

References 42 publications

Cadmium Exposure and Liver Disease among US Adults

Cadmium Exposure and Liver Disease among US Adults

Oxidative stress in rat liver during acute cadmium and ethanol intoxication

Association between blood cadmium levels and malnutrition in peritoneal dialysis

Contact Info

Product

Resources

About