Intoxicação espontânea por vagens de Prosopis juliflora (Leg. Mimosoideae) em bovinos no Estado de Pernambuco

Câmara, Antônio Carlos Lopes; Costa, Nivaldo de Azevêdo; Riet-Correa, Franklin; Afonso, José Augusto Bastos; Dantas, Antônio Flávio Medeiros; Mendonça, Carla Lopes de; Souza, Maria Isabel de

doi:10.1590/s0100-736x2009000300008

Cited by 21 publications

(29 citation statements)

References 12 publications

(21 reference statements)

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“…Nos animais a campo, esses não devem permanecer mais de 60 dias em áreas com algaroba. Vagens de algaroba também podem ser utilizadas em animais de engorda na fase de terminação , Câmara et al 2009.…”

Section: Discussionunclassified

Doenças do sistema nervoso de bovinos no semiárido nordestino

et al. 2010

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Para determinar as doenças que ocorrem no sistema nervoso de bovinos no semiárido nordestino, foi realizado um estudo retrospectivo em 411 necropsias de bovinos realizadas no Hospital Veterinário da Universidade Federal de Campina Grande, Patos, Paraíba, entre janeiro de 2000 a dezembro de 2008. Dos 411 casos analisados 139 (33,81%) apresentaram alterações clínicas do sistema nervoso e as fichas foram revisadas para determinar os principais achados referentes à epidemiologia, aos sinais clínicos e às alterações macroscópicas e microscópicas. Em 28 (20,14%) casos o diagnóstico foi inconclusivo. As principais enfermidades foram raiva (48,7% dos casos com sinais nervosos), abscessos cerebrais (7,2%) incluindo três casos de abscesso da pituitária, febre catarral maligna (6,3%), botulismo (6,3%), alterações congênitas (4,5%), traumatismo (4,5%), tuberculose (2,7%), tétano (2,7%), infecção por herpesvírus bovino-5 (2,7%), encefalomielite não supurativa (2,7%), intoxicação por Prosopis juliflora (2,7%), status spongiosus congênito de causa desconhecida (1,8%) e polioencefalomalacia (1,8%). Outras doenças diagnosticadas numa única oportunidade (0,9%) foram criptococose, listeriose, encefalite tromboembólica, linfossarcoma, tripanossomíase e babesiose por Babesia bovis.

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Section: Discussionunclassified

Doenças do sistema nervoso de bovinos no semiárido nordestino

et al. 2010

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“…A synergistic action of piperidine alkaloids has been suggested to be responsible for the neurotoxic damage observed in cattle and goats after intensive ingestion of Prosopis juliflora (Câmara et al 2009, Hughes et al 2006, Silva et al 2007, 2013, Tabosa et al 2000a, 2000b. Tabosa et al (2000a) found that the toxic activity observed in mice is chemically related to piperidine alkaloids such as juliprosopine present in the pods of this Leguminosae.…”

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“…It was already known that intoxication of animals by alkaloids from P. juliflora induces cytoplasmic vacuolation in neurons (Tabosa et al 2000b, 2006, Câmara et al 2009). In a previous in vitro study, we characterized autophagy in astrocytes and neurons after exposure to TAE and fraction F32.…”

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Autophagy protects against neural cell death induced by piperidine alkaloids present in Prosopis juliflora (Mesquite)

Silva

Cuevas

Muñoz

et al. 2017

An. Acad. Bras. Ciênc.

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Prosopis juliflora is a shrub that has been used to feed animals and humans. However, a synergistic action of piperidine alkaloids has been suggested to be responsible for neurotoxic damage observed in animals. We investigated the involvement of programmed cell death (PCD) and autophagy on the mechanism of cell death induced by a total extract (TAE) of alkaloids and fraction (F32) from P. juliflora leaves composed majoritary of juliprosopine in a model of neuron/glial cell co-culture. We saw that TAE (30 µg/mL) and F32 (7.5 µg/mL) induced reduction in ATP levels and changes in mitochondrial membrane potential at 12 h exposure. Moreover, TAE and F32 induced caspase-9 activation, nuclear condensation and neuronal death at 16 h exposure. After 4 h, they induced autophagy characterized by decreases of P62 protein level, increase of LC3II expression and increase in number of GFP-LC3 cells. Interestingly, we demonstrated that inhibition of autophagy by bafilomycin and vinblastine increased the cell death induced by TAE and autophagy induced by serum deprivation and rapamycin reduced cell death induced by F32 at 24 h. These results indicate that the mechanism neural cell death induced by these alkaloids involves PCD via caspase-9 activation and autophagy, which seems to be an important protective mechanism.

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“…A intoxicação por vagens de algaroba tem sido descrita em bovinos (Silva et al 2006, Tabosa et al 2006, Câmara et al 2009) e caprinos (Tabosa et al 2000, Lima et al 2004, Assis et al 2009) causando um quadro clínico de disfunção de nervos cranianos, principalmente do núcleo motor do trigêmeo. Os caprinos têm que ingerir concentrações de 60%-90% de vagens na alimentação por um período de aproximadamente 210 dias para apresentar sinais clínicos (Tabosa et al 2000).…”

Section: Introductionunclassified

Utilização de vagens de Prosopis juliflora na alimentação de ovinos e caprinos

et al. 2012

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Pesq. Vet. Bras. 32(10):987-989, outubro 2012 987 RESUMO.-Sinais nervosos associados à ingestão de vagens de Prosopis juliϔlora tem sido descritos em caprinos adultos pastejando continuamente em áreas invadidas por esta planta. A doença não tem sido constatada em ovinos, mas nesta espécie o pastejo em áreas invadidas por P. juliϔlora tem sido associado à ocorrência de malformações. O presente trabalho objetivou estudar a toxicidade sobre o sistema nervoso e o efeito teratogênico de vagens de P. juliϔlora (algaroba) In Brazil, nervous signs caused by the ingestion of Prosopis juliϔlora pods have been reported in goats grazing in areas invaded by this plant. The disease has not been reported in sheep, but in this species, grazing in areas invaded by P. juliϔlora has been associated with the occurrence of malformations in lambs. The objective of this research was to study the toxicity for the central nervous system and the teratogenicity of P. juliϔlora pods in sheep, and to determine their toxicity to goats. Three experiments were performed. In Experiment 1, groups of four sheep were fed with ration containing 0, 60% or 90% of pods. In Experiment 2, seven sheep were fed with pods in amount equivalent to 2.1% body weight (bw) during the whole gestation. In Experiment 3, three goats were fed with pods in amounts equivalent to 1.5% of their bw during 264, 474, and 506 days. None of the experimental animals showed nervous signs and the seven pregnant sheep delivered normal lambs. These results suggest that P. juliϔlora pods can be used without restrictions in the food of sheep. Because in a previous paper P. juliϔlora pods, in the concentratiosn of 60% and 90% of the food, caused nervous signs in goats after 210 days of ingestion, it is suggested that there are variation in the toxicity of the pods. It is recommended that goats may be kept in areas invaded by P. juliϔlora for no more than one fructiϐication period.

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Intoxicação espontânea por vagens de Prosopis juliflora (Leg. Mimosoideae) em bovinos no Estado de Pernambuco

Cited by 21 publications

References 12 publications

Doenças do sistema nervoso de bovinos no semiárido nordestino

Doenças do sistema nervoso de bovinos no semiárido nordestino

Autophagy protects against neural cell death induced by piperidine alkaloids present in Prosopis juliflora (Mesquite)

Utilização de vagens de Prosopis juliflora na alimentação de ovinos e caprinos

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