Intoxicação Aguda Por Organofosforado Em Bovinos Do Paraná, Brasil

Abstract

* Correspondência: perotta@ufpr.br RESUMO: Relata-se a intoxicação aguda por organofosforado em bovinos mestiços zebuínos, criados no Paraná. Dos sessenta animais pulverizados com solução de diazinon, com concentração aproximada superior a cinco vezes a dose recomendada para controle de ectoparasitas, 51 morreram no intervalo de 24 horas. Os sinais clínicos mais evidentes foram tremores musculares, sialorreia, timpanismo, miose, prostração, decúbito, culminando com o óbito. Esse tipo de acidente ainda ocorre no Brasil em decorrência do insuficiente treinamento do pessoal que manipula esses produtos e a possibilidade de os adquirirem sem receituário médico veterinário.Palavras-chave: diazinon; mortalidade; acidente; envenenamento ABSTRACT: An acute organophosphate poisoning in bovine Zebu-mixed breed cattle, raised in Parana state, Brazil has been reported. Out of sixty animals sprayed with diazinon solution, with approximated concentration over 5-fold the recommended dose for ectoparasite control, 51 died within 24-hour interval. The most evident clinical signs were muscle tremors, sialorrhea, bloat, miosis, prostration, decubitus, leading to death. This type of accident may still occur in Brazil as consequence of insufficient training of personal who handle such products and the possibility of purchase them without veterinarian prescription.

Spontaneous and experimental poisoning by nitroxinil at 34% in goats

“…Also, environmental temperature and physical exercise are factors that enhance the onset of the intoxication, since phenolic substitutes increase cell metabolism and the need for oxygen (Legendre 1973). The outbreak occurred in a semi-arid climatic region, where temperatures can reach 33 o C (INMET 2010) which, in combination with physical exercise, could have contributed to the increase in the animal's metabolism and, consequently, greater absorption of the vermifuge (Meerdink 1989, Mendonça et al 2010, Bertoni et al 2017. Poisoning by other antiparasitic drugs, such as organophosphates and pyrethroids, mainly affect animals that receive an overdose of the drug in combination with high environmental temperature and physical effort (Bertoni et al 2017).…”

“…Pharmacological intoxications in animals occur because of overdose of medications, exceeding the recommended dose several times (Furlan et al 2009). It is believed that these poisonings occur in a large number of animals, due to the lack of information and neglect in the use of medications (Bertoni et al 2017). Although the optimal dose of drugs is clearly indicated on the package insert or medical prescription, not weighing the animals, leading to erroneous estimates of weight, or dividing by categories (age and sex), are the main causes of overdose in veterinary medicine (Chagas et al 2013).…”