Intestinal Uptake of Valine in Calorie and Protein Deprivation

Steiner, Manfred; Farrish, Grover C. M.; Gray, Seymour J.

doi:10.1093/ajcn/22.7.871

Cited by 15 publications

(3 citation statements)

References 22 publications

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“…The possibility that the threefold difference in uptake of histidine from free amino acid and dipeptide was the result of chance variation between two halves of the same biopsy specimen is remote. Steiner et al (1969) reported that estimates of amino acid uptake by duplicate biopsy specimens agreed within ±10%. An interesting feature of this case is that though the biopsy showed evidence of ability to take up histidine from glycylhistidine, the tolerance curves did not suggest that histidine absorption from this peptide was any better than from the free amino acid.…”

Section: Discussionmentioning

confidence: 93%

“…Part of a control biopsy showing subtotal villous atrophy due to coeliac disease taken for diagnostic purposes from a child aged 3 years was incubated in L-histidine 5 iLmol/ml under similar conditions. Amino acid uptake and concentration in intracellular water were calculated as by Cheng et al (1971) using figures for total water content and extracellular space given by Steiner, Farrish, and Gray (1969). Uptake of glycine from glycylhistidine by Hartnup biopsy portion (B) was calculated on the assumption that the initial glycine content of this specimen was the same as the final glycine content of portion (A).…”

Section: Case Reportmentioning

confidence: 99%

See 1 more Smart Citation

Absorption of Amino Acids and Peptides in a Child with a Variant of Hartnup Disease and Coexistent Coeliac Disease

Tarlow¹,

Seakins²,

Lloyd³

et al. 1972

Archives of Disease in Childhood

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Section: Discussionmentioning

confidence: 93%

Section: Case Reportmentioning

confidence: 99%

Absorption of Amino Acids and Peptides in a Child with a Variant of Hartnup Disease and Coexistent Coeliac Disease

Tarlow¹,

Seakins²,

Lloyd³

et al. 1972

Archives of Disease in Childhood

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“…The data suggest an increase in the maximum secretory capacity of Z Fed (6) \ T the starved gut rather than any significant change in the affinity that gives the ED50 dose (fed jejuna=92 itmol, 72 h starved jejuna=64 [imol).…”

Section: Time Courses Of Changes In Isc Induced By Secretagoguesmentioning

confidence: 85%

Diarrhoea of famine and malnutrition: investigations using a rat model. 1. Jejunal hypersecretion induced by starvation.

Young

Levin

1990

Gut

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The effects of progressive starvation for up to three days on the secretory functions of the intestine were investigated using in vitro and in vivo preparations of rat jejunum and secretagogues whose action was either through cyclic AMP or Ca". Initial starvation for 24 h (day 1) did not significantly alter the basal net electrogenic ion secretion measured in vitro as the short circuit current (Isc, [tamps/cm2) or the change in electrogenic ion secretion (A Isc) induced by the secretagogues. By day 2 of starvation, however, the maximum A Isc transient induced by the cholinergic and other secretagogues (A Isc=Isc max-basal Isc) was greatly increased (up to a maximum of 117%) compared with the fed controls on an area basis. The A Isc were even greater on day 3 of starvation. If a tissue weight basis was used to normalise the data the increase became even more marked. The enhancement in secretion was not caused by a decrease in absorptive capacity as glucose, added mucosally, gave larger increases in absorptive currents in the starved than in the fed jejuna. Bethanecol dose-A Isc response curves in fed and starved jejuna showed an increase in the maximum electrogenic secretion in the starved but no apparent change in the affinity of their cholinergic receptors mediating the enhanced secretion. The starvation-induced increase in secretion elicited by bethanecol was blocked by atropine, indicating that the receptors were muscarinic, but was unaffected by tetrodotoxin indicating that the enteric neural innervation was not essential for its expression. Noradrenaline released by tyramine was greater in the starved than the fed jejunum, suggesting that a decreased sympathetic tone was unlikely to be the major cause of the starvation induced secretory enhancement. Measurement of jejunal fluid movements in vivo showed that in fed controls and throughout the three days of starvation there was an unchanged net fluid absorption in the basal, unstimulated state. By day 2 and day 3 of starvation, however, bethanecol stimulated fluid secretion was very much greater than that of the fed controls. This increase in fluid secretion was concomitant with significant increases in the concentration of chloride in the lumenal fluid. Starvation thus appears to make the rat jejunum hypersensitive to cholinergic and other secretagogues, increasing the electrogenic secretion of chloride in vitro and that of chloride and fluid in vivo.These results obtained with the rat model give a new insight into possible mechanisms by which the diarrhoea of human famine and malnutrition may be expressed.

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Dietary Treatment of Obesity

Howard¹

1975

Obesity: Its Pathogenesis and Management

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Intestinal Uptake of Valine in Calorie and Protein Deprivation

Cited by 15 publications

References 22 publications

Absorption of Amino Acids and Peptides in a Child with a Variant of Hartnup Disease and Coexistent Coeliac Disease

Absorption of Amino Acids and Peptides in a Child with a Variant of Hartnup Disease and Coexistent Coeliac Disease

Diarrhoea of famine and malnutrition: investigations using a rat model. 1. Jejunal hypersecretion induced by starvation.

Dietary Treatment of Obesity

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