Intestinal Transport of Taurocholate in the Cat*

Wolffram, Siegfried; Grenacher, Beat; Scharrer, E.

doi:10.1111/j.1439-0442.1993.tb00614.x

Cited by 2 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The overall mean uptake per milligram was 7.45 Ϯ 0. 44,6.54 Ϯ 0.92, and 7.37 Ϯ 0.81 nmol · mg Ϫ1 · min Ϫ1 at 15, 20, and 26 d of age, respectively. These uptake measurements are similar to those of recent previous experiments in same-age pups, indicating that glucose transporter activity in these intestines was normal (16,29).…”

Section: Corticosterone Studymentioning

confidence: 94%

Ontogenetic Development of Rat Intestinal Bile Acid Transport Requires Thyroxine But Not Corticosterone

2004

View full text Add to dashboard Cite

Absorption of bile acids by the distal ileum is an essential component of the enterohepatic circulation. In neonatal rats, the appearance of the apical sodium-dependent bile acid transporter (ASBT) at 17 d of age coincides with increases in serum corticosterone and thyroxine. We tested the hypothesis that these hormones modulate ASBT expression during ileal development. Taurocholate uptake into the isolated ileum of normal 20-d-old pups exhibited saturable (K m ϭ 0.52 mM, J max ϭ 0.34 pmol mg/min) and nonsaturable (K diff ϭ 0.015 min Ϫ1 ) components and was two to five times greater than uptake in the proximal intestine. Hypothyroid or euthyroid pups received daily thyroxine injections starting at 6 d of age. At 12 d of age, serum concentrations of thyroxine, ileal abundance of ASBT mRNA, and ileal rates of taurocholate uptake were low in hypothyroid pups that received an injection of vehicle (HTϪ) or thyroxine (HTϩ) and in euthyroid pups that received an injection of vehicle (ETϪ) or thyroxine (ETϩ). At 20 and 26 d, ileal ASBT mRNA abundance and taurocholate uptake rate remained low in HTϪ pups but increased dramatically in ETϪ and ETϩ pups, paralleling the increase in serum thyroxine. Restoration of normal plasma thyroxine in HTϪ pups by thyroxine injections (HTϩ) restored normal ASBT development. Sodium-glucose co-transporter activity and mRNA expression were independent of serum thyroxine levels. Corticosterone levels were significantly lower in pups that were adrenalectomized at 10 d of age. ASBT mRNA abundance and taurocholate uptake rate increased markedly with age but were the same in adrenalectomized, sham-operated, and nonoperated pups. Hence, endogenous thyroxine but not corticosterone regulates the developmentally timed appearance of ASBT. Bile acids expelled from the gallbladder into the intestinal lumen emulsify dietary lipids to aid digestion, then form micelles with the products of lipid digestion to facilitate absorption. Synthesis of bile acids by the liver is insufficient to meet physiologic needs, and bile acids are recycled in a process that involves their absorption from the intestinal lumen back into the circulation and eventual resecretion from the liver. Bile acids are absorbed passively and in modest amounts in the jejunum (1) but are absorbed actively and in greater amounts in the distal ileum by the apical sodium-dependent transporter (ASBT) located at the brush border membrane of the enterocyte (2). It is not clear when active bile acid absorption begins during ontogenetic development of the small intestine. Sodium-dependent uptake of the bile acid taurocholate has been observed in the small intestine of an 8-mo-old child but not in that of a fetus or a neonate (3). Because reabsorption in the distal small intestine of neonates is inefficient or absent,~10 -20% of fat intake in the formula-fed newborn is thought to be malabsorbed, even though the rate of bile acid synthesis in the neonatal liver is markedly higher than that of older age groups. In rat pups, ASBT mRNA, protein, and ac...

show abstract

Section: Corticosterone Studymentioning

confidence: 94%

Ontogenetic Development of Rat Intestinal Bile Acid Transport Requires Thyroxine But Not Corticosterone

2004

View full text Add to dashboard Cite

show abstract

“…[ 10 ] Many pharmacokinetics studies have reported that CiA can easily be absorbed from the small intestine through various mechanisms including passive diffusion, [ 11 ] monocarboxylic acid transporters, [ 12 ] and Na + ‐dependent career‐mediated transport mechanisms. [ 13 ] Our previous in vitro study had reported the antioxidant and antiapoptotic properties of CiA. [ 14 ] It was also found to preserve mitochondrial function and maintain calcium homeostasis.…”

Section: Introductionmentioning

confidence: 99%

Cinnamic acid is beneficial to diabetic cardiomyopathy via its cardioprotective, anti‐inflammatory, anti‐dyslipidemia, and antidiabetic properties

Nair

Rani

Raj

et al. 2022

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Diabetes-related health issues are increasing day by day in public, and diabetic cardiomyopathy (DCM) is one serious issue among them. There is a lack of proper strategy to control and manage DCM. Here we are attempting a nutraceutical-based approach to protect the heart from DCM. The beneficial effect of cinnamic acid (CiA), was evaluated in an experimental model of diabetes. For this, diabetic model was created by feeding male Wistar rats with a high fat, high fructose diet for 6 months and a single dose of streptozotocin (25 mg/kg bwt). Metformin was used as the positive control. The diabetic rats showed insulin resistance, myocardial injury, and a significant increase of total cholesterol, triglycerides, and LDL. Development of DCM was evident from the increased cardiac mass index, LDH, CKMB, ANP, and CRP levels in the diabetic group. There was a significant increase in the levels of cardiac hypertrophy markers like TGF-β and β-MHC in the hearts of diabetic rats revealing DCM. Pro-inflammatory cytokines (TNF-α, IL-6) and lipid peroxides were significantly elevated in the serum of diabetic rats. Histopathology revealed inflammation and necrosis in the heart of diabetic rats confirming DCM. Oral administration of CiA (5 and 10 mg/kg bwt) prevented the development of DCM via its cardioprotective, anti-inflammatory, anti-dyslipidemia potential, and antidiabetic properties. Similarly, metformin (50 mg/kg bwt) has also shown protection against DCM. We conclude from this study that CiA is found to be beneficial against DCM and recommend more detailed preclinical and clinical studies to develop CiA-based nutraceutical against DCM.

show abstract

Intestinal Transport of Taurocholate in the Cat*

Cited by 2 publications

References 26 publications

Ontogenetic Development of Rat Intestinal Bile Acid Transport Requires Thyroxine But Not Corticosterone

Ontogenetic Development of Rat Intestinal Bile Acid Transport Requires Thyroxine But Not Corticosterone

Cinnamic acid is beneficial to diabetic cardiomyopathy via its cardioprotective, anti‐inflammatory, anti‐dyslipidemia, and antidiabetic properties

Contact Info

Product

Resources

About