Intestinal stents: Structure, functionalization and advanced engineering innovation

Feng, Yusheng; Chen, Yufeng; Chen, Ying; He, Xiaowen; Khan, Yousef; Hu, Hong; Lan, Ping; Li, Yang; Wang, Xiaoqin; Li, Gang; Kaplan, David L.

doi:10.1016/j.bioadv.2022.212810

Cited by 9 publications

(5 citation statements)

References 122 publications

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“…And intestinal stents can affect the blood supply and reduce the blood supply to colon tumors. Colon tumor growth requires large amounts of oxygen and nutrients, and if the blood supply is reduced, the reproductive capacity of CC cells will be inhibited (Feng et al, 2022). This aligns with Matsuda et al ( 2019) observations, suggesting that mechanical compression induced by intestinal stents could hinder cancer cell proliferation in cases of malignant large bowel obstruction.…”

Section: Discussionsupporting

confidence: 76%

The Impact of Atmospheric Cadmium Exposure on Colon Cancer and the Invasiveness of Stents within the Cancerous Colon

Zhang,

Li,

et al. 2024

Preprint

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Background: Inhalation exposure to carcinogenic metals like cadmium (Cd) is a significant global health concern linked to various cancers. However, understanding their precise carcinogenic mechanism remains elusive. Methods: Using the colon cancer (CC) rat model and implanted intestinal stent, exposed them to atomized oxygen and nitrogen (O2/N2) gas containing Cd. Results: Atmospheric Cd intensified inflammation in CC cells, heightening nicotinamide adenine dinucleotide phosphate 1 (NOX1) activity, generating increased reactive oxygen species (ROS). This escalated ROS production triggered abnormal Wnt protein secretion, activating the Wnt/β-catenin pathway, stimulating CC cell proliferation. No discernible body weight effect was seen in CC mice, possibly due to later-stage tumor weight gain, masking rat changes. Cd facilitated colon tumor restructuring and cell migration later. Intestinal stents inhibited superoxide dismutase 1 (SOD1) in CC mice's tumors, with no clear effects on NOX1, SOD2, and catalase (CAT) enzymes. Elevated ROS levels didn't substantially impact Wnt/β-catenin and might slow its imbalance. Stent implantation eased inflammation, reducing CC cell proliferation but induced discomfort in rats, reducing food intake and weight. Conclusion: Cd might partially foster CC tumorigenesis via the ROS-mediated Wnt/β-catenin pathway. The effect of Cd on the invasive effect of intestinal stents in cancerous colon was not significant.

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Section: Discussionsupporting

confidence: 76%

The Impact of Atmospheric Cadmium Exposure on Colon Cancer and the Invasiveness of Stents within the Cancerous Colon

Zhang,

Li,

et al. 2024

Preprint

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“…Additionally, intestinal stents can reduce the blood supply to colon tumors. Colon tumor growth requires large amounts of oxygen and nutrients, and if the blood supply is reduced, the reproductive capacity of CC cells will be inhibited [ 47 ]. This aligns with Matsuda’s [ 48 ] observations, suggesting that the mechanical compression induced by intestinal stents could hinder cancer cell proliferation in cases of malignant large bowel obstruction.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Atmospheric Cadmium Exposure on Colon Cancer and the Invasiveness of Intestinal Stents in the Cancerous Colon

Zhang,

Li,

et al. 2024

Toxics

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Background: Inhalation exposure to carcinogenic metals such as cadmium (Cd) is a significant global health concern linked to various cancers. However, the precise carcinogenic mechanism underlying inhalation exposure remains elusive. Methods: In this study, CT26 mouse colon cancer (CC) cells were implanted into BALB/c mice to establish CC mouse models. Some of the CC mice were implanted with intestinal stents. The mice were exposed to atomized oxygen and nitrogen (O2/N2) gas containing Cd. Results: Atmospheric Cd intensified inflammation in CC cells and heightened Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase 1 (NOX1) activity, which is an indirect measurement of increased reactive oxygen species (ROS) production. This escalated ROS production triggered abnormal Wnt protein secretion, activated the Wnt/β-catenin signaling pathway, and stimulated CC cell proliferation. No discernible body weight effect was seen in the CC mice, possibly due to the later-stage tumor weight gain, which masked the changes in body weight. Cd facilitated colon tumor restructuring and cell migration at the later stage. The implantation of intestinal stents inhibited the expression of Superoxide Dismutase 1 (SOD1) in the colon tumors of the CC mice, with no evident effects on the expression levels of NOX1, SOD2, and Catalase (CAT) enzymes. Elevated ROS levels, indirectly reflected by enzyme activity, did not substantially impact the Wnt/β-catenin signaling pathway and even contributed to slowing its imbalance. Stent implantation eased the inflammation occurring in colon tumors by reducing CC cell proliferation but it induced discomfort in the mice, leading to a reduction in food intake and weight. Conclusions: Cd partially fosters CC tumorigenesis via the ROS-mediated Wnt/β-catenin signaling pathway. The effect of Cd on the invasive effect of intestinal stents in the cancerous colon is not significant.

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“…Metal stents, such as self-expanding metal stents, have been increasingly used as intestinal stents for the treatment of malignant large bowel obstruction [10,11]. Metals, such as nickel-titanium memory alloys and stainless steel, are the main material choices for self-expanding colorectal stents [12,13].…”

Section: Intestinal Stentsmentioning

confidence: 99%

“…Therefore, the selection of suitable liver scaffolds for preparation is a fundamental research task in liver transplantation. Research on liver tissue engineering scaffold materials is still in the stage of screening for applicability, with the main focus on degradable polymeric materials and natural matrix materials that show promising performance in structural tissue engineering, as listed and compared in Table 1 [11]. Natural biological scaffolds are gaining increasing attention due to their appropriate immune response, mild antigenic properties, and good hemostatic properties [41].…”

Section: Liver Stent Materialsmentioning

confidence: 99%

Advancement on Digestive Tract Biomedical Stents, A Review

Sun,

Wang,

et al. 2023

JFBI

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Biomedical stents for the digestive tract address many of the limitations associated with traditional surgical treatments for gastrointestinal diseases. This paper provides a review of the performance requirements, complications, and limitations of stent materials in the treatment of common digestive tract diseases. The advantages and disadvantages of different materials and processing technologies for digestive tract stents are discussed. Furthermore, considering the diverse requirements for ideal alimentary canal stent materials, the challenges that require further research are outlined in detail, providing strategic references for the development of biomedical stents for the digestive tract.

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Intestinal stents: Structure, functionalization and advanced engineering innovation

Cited by 9 publications

References 122 publications

The Impact of Atmospheric Cadmium Exposure on Colon Cancer and the Invasiveness of Stents within the Cancerous Colon

The Impact of Atmospheric Cadmium Exposure on Colon Cancer and the Invasiveness of Stents within the Cancerous Colon

The Impact of Atmospheric Cadmium Exposure on Colon Cancer and the Invasiveness of Intestinal Stents in the Cancerous Colon

Advancement on Digestive Tract Biomedical Stents, A Review

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