Intestinal parasitic infections and eosinophilia in an human immunedeficiency virus positive population in Honduras

Kaminsky, Rina Girard de; Soto, Ramón Jeremías; Campa, Adriana; Baum, Marianna K.

doi:10.1590/s0074-02762004000700020

Cited by 40 publications

(34 citation statements)

References 22 publications

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“…Kaminsky et al [23] and Tristão et al [20] observed, as we did, that intestinal infection by helminthes in HIV-positive patients resulted in immune responses involving eosinophilia.…”

Section: Discussionsupporting

confidence: 80%

“…Reinforcing what has already been said above through another analysis (Mann-Whitney non parametric test) that eosinophils have a significant association with the presence of helminthes, suggesting that in the absence of a stool test for parasites, eosinophilia finding should indicate its performance and, occasionally, make anti-helminthic treatment [23].…”

Section: Discussionsupporting

confidence: 76%

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Enteroparasitosis prevalence and parasitism influence in clinical outcomes of tuberculosis patients with or without HIV co-infection in a reference hospital in Rio de Janeiro (2000-2006)

Neto

Oliveira²,

Totino³

et al. 2009

Braz J Infect Dis

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Tuberculosis and intestinal parasites affect primarily low social and economic level populations, living clustered in precarious habitational settings. One of the interesting aspects of this interaction is the parasitism influence in cellular response to tuberculosis. In the present study, we evaluated the prevalence of enteroparasitosis in tuberculosis patients, HIV-infected and non HIV infected, and we observed the influence of helminth presence in the response to tuberculin skin test (TST) and tuberculosis clinical outcomes. From 607 clinical records reviewed, 327 individuals met the study inclusion criteria and did not present any exclusion criteria. The prevalence of enteroparasites observed was 19.6%. There was no significant association among TST result and the variables related to the presence of: helminthes, protozoa, and stool test for parasites result (p>0.5). Considering the survival of this cohort, we may observe that there is no significant difference (p>0.05) between the survival curves of parasited and non parasited individuals. Solely the variable "eosinophils" presents a statistically significant association (p<0.001) with helminthes, all other associations are considered not significant. Our findings neither show an association between helminthic infection and a favorable tuberculosis outcome, nor between parasitism and TST response, unlike other in vitro studies. Apparently, experimental data do not correspond to the clinical findings.

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“…Kaminsky et al [23] and Tristão et al [20] observed, as we did, that intestinal infection by helminthes in HIV-positive patients resulted in immune responses involving eosinophilia.…”

Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 76%

Enteroparasitosis prevalence and parasitism influence in clinical outcomes of tuberculosis patients with or without HIV co-infection in a reference hospital in Rio de Janeiro (2000-2006)

Neto

Oliveira²,

Totino³

et al. 2009

Braz J Infect Dis

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“…In resource-poor settings, intestinal helminths are generally considered the main cause of eosinophilia [22][23][24]. This study underlines the predominant role of intestinal helminthiases in eosinophilia: in individuals with a helminthic infection (in the absence of ectoparasites), the prevalence of eosinophilia was over 60% and logistic regression revealed that the presence of intestinal helminthiases was the best predictor of eosinophilia.…”

Section: Discussionmentioning

confidence: 72%

Anemia, leukocytosis and eosinophilia in a resource-poor population with helmintho-ectoparasitic coinfection

Pilger

Heukelbach

Diederichs

et al. 2010

J Infect Dev Ctries

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Introduction: Eosinophilia and anemia are very common hematological alterations in the tropics but population-based studies scrutinizing their value for diagnosing parasitic infections are rare. Methodology: A cross-sectional study was conducted in a rural district in northeast Brazil where parasitic infections are common. Stool and blood samples were collected and individuals were clinically examined for the presence of ectoparasites. Results: In total, 874 individuals were examined. Infection with intestinal helminths occurred in 70% (95% CI 67 -75), infestation with ectoparasites in 45% (95% CI 42 -49) and co-infection with both helminths and ectoparasites was found in 33% (95% CI 29% -36%) of all inhabitants. Eosinophil counts ranged from 40/µl to 13.800/µl (median: 900/µl). Haemoglobin levels ranged from 4.8 g/dl to 16.8 g/dl (median: 12.5 g/dl), and anemia was present in 24% of the participants. Leukocytosis was found in 13%, eosinophilia in 74%, and hypereosinophilia in 44% of the participants. Eosinophilia was more pronounced in individuals co-infected with intestinal helminths and ectoparasites (p < 0.001) and correctly predicted parasitic infection in 87% (95% CI 84%-90.7%) of all cases. Conclusions: Eosinophilia is strongly associated with the presence of intestinal helminthiases and accentuated by co-infestation with ectoparasites. Our study confirms in a population with high prevalence of intestinal helminthiases and ectoparasites that eosinophilia can be used to accurately diagnose current parasitic infection and initiate treatment.

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“…Apart from this enteroparasite, G. lamblia, S. stercoralis and I. belli were also evidenced but without this association. Interestingly, KAMINSKY et al 51 studied HIV seropositive individuals in Honduras and did not identify any cases of giardiasis, amebiasis and cryptosporidiosis. The authors demonstrated a strong association between eosinophilia and the presence of intestinal helminthosis caused by Trichuris trichiura (11%), A. lumbricoides (12%) and S. stercoralis (13.2%).…”

Section: Parasitesmentioning

confidence: 99%

Etiological agents of diarrhea in patients infected by the human immunodeficiency virus-1: a review

Rossit¹,

Gonçalves

Franco

et al. 2009

Rev. Inst. Med. trop. S. Paulo

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Despite the importance of understanding the epidemiology of agents responsible for infectious diarrhea in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) population, the number of articles about this subject is relatively few. The current article summarizes published data on bacterial, fungal, viral and parasitic enteropathogens in the HIV/AIDS seropositive subjects in different countries, regions and localities. In general, there is a great difference in the frequencies of etiological agents due to factors which include immune status, geographical location, climate and socioeconomic conditions. It is important to stress that a great prevalence of infection by emergent agents has been reported in the more advanced stages of AIDS. Therefore, to establish specific treatment depends directly on knowledge of these agents and risk factors associated to their distribution. Moreover, the colonization by potential pathogenic agents verified in these individuals is high thus implicating that they act as carriers. Finally, public health measures of control and prevention must take into consideration the regional previously identified enteropathogens, especially in areas where HIV prevalence is high.

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Intestinal parasitic infections and eosinophilia in an human immunedeficiency virus positive population in Honduras

Cited by 40 publications

References 22 publications

Enteroparasitosis prevalence and parasitism influence in clinical outcomes of tuberculosis patients with or without HIV co-infection in a reference hospital in Rio de Janeiro (2000-2006)

Enteroparasitosis prevalence and parasitism influence in clinical outcomes of tuberculosis patients with or without HIV co-infection in a reference hospital in Rio de Janeiro (2000-2006)

Anemia, leukocytosis and eosinophilia in a resource-poor population with helmintho-ectoparasitic coinfection

Etiological agents of diarrhea in patients infected by the human immunodeficiency virus-1: a review

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