Intestinal parasites and diabetes: A systematic review and meta-analysis

Zibaei, Mohammad; Bahadory, Saeed; Saadati, Hassan; Pourrostami, Kumars; Firoozeh, Farzaneh; Foroutan, Masoud

doi:10.1016/j.nmni.2022.101065

Cited by 5 publications

(1 citation statement)

References 49 publications

(47 reference statements)

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“…Separate studies report that H. pylori is not associated with either insulin resistance or the prevalence of T2DM [38,39]. The likelihood of such a conclusion is most probably associated with the inclusion in the study of T2DM patients without significant chronic hyperglycemia or with well-corrected hypoglycemic therapy.…”

Section: Discussionmentioning

confidence: 99%

The significance of chronic hyperglycemia for the reduced efficacy of eradication therapy in patients with type 2 diabetes mellitus and for Helicobacter pylori survival

Bektemirova,

Maev,

Dicheva

et al. 2023

Explor Dig Dis

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Aim: This study aims to determine the significance of chronic hyperglycemia for the reduced efficacy of eradication therapy in patients with type 2 diabetes mellitus (T2DM) and Helicobacter pylori (H. pylori)-associated upper gastrointestinal tract pathology as well as for H. pylori survival. Methods: A prospective randomized study with the participation of 180 patients (87 men and 93 women) with H. pylori-associated upper gastrointestinal pathology was carried out. Ninety of these patients were with T2DM and 90 were without diabetes mellitus (DM). The patients were divided into 4 groups of 45 patients: the group 1 included non-diabetic patients treated with the classical triple eradication scheme; the group 2 included patients with T2DM treated with the classical triple eradication scheme; the group 3 included non-diabetic patients treated with bismuth quadro-therapy; the group 4 included patients with T2DM treated with bismuth quadro-therapy. The presence of H. pylori and evaluation of eradication efficacy was carried out using the Helix breath test. Results: The effectiveness of 1st line anti-Helicobacter therapy was higher (88.2%) in patients without diabetes in comparison with the group of patients with concomitant T2DM (74.7%). The efficacy of classical triple eradication therapy in patients with concomitant T2DM was 69.1%, and quadro-therapy was 80.5%. There was significantly lower effectiveness (P < 0.017) of eradication therapy in patients with T2DM and glycated hemoglobin (HbA1c) level ≥ 7.0% as compared with the group of patients in whom the target (≤ 6.5%) level of HbA1c was achieved. Conclusions: Chronic hyperglycemia has a favorable effect on the viability of H. pylori bacteria in patients with T2DM. A hypothesis explaining the reduced efficacy of eradication therapy in patients with hyperglycemia has been proposed.

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Section: Discussionmentioning

confidence: 99%

The significance of chronic hyperglycemia for the reduced efficacy of eradication therapy in patients with type 2 diabetes mellitus and for Helicobacter pylori survival

Bektemirova,

Maev,

Dicheva

et al. 2023

Explor Dig Dis

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Improving faster R-CNN generalization for intestinal parasite detection using cycle-GAN based data augmentation

Kumar,

Arif,

Ahamad

et al. 2024

Discov Appl Sci

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Intestinal parasites pose a widespread challenge in underdeveloped and developing countries, afflicting millions of individuals. Traditional, manual light microscopes have been golden method for detecting these parasites, but they are not only expensive but also time-consuming and require specialized expertise. Recent advances in deep learning, however, have shown promise for overcoming these obstacles. The condition is that deep learning models require labeled medical imaging data, which is both scarce and costly to generate. This makes it difficult to establish universal deep learning models that required extensive amounts of data. To improve the performance of deep learning, we employed a generative adversarial network to fabricate a synthetic dataset. Our framework exploits the potential of Generative Adversarial Networks (CycleGANs) and Faster RCNN to generate new datasets and detect intestinal parasites, respectively, on images of varying quality, leading to improved model generalizability and diversity. In this experiment, we evaluated the effectiveness of Cycle Generative Adversarial Network (CycleGAN) + Faster RCNN. We employed widely-used evaluation metrics such as precision, recall, and F1-score. We demonstrated that the proposed framework effectively augmented the image dataset and improved the detection performance, with an F1-Score of 0.95 and mIoU of 0.97 are achieved, which is better than without data augmentation. We show that this state-of-the-art approach sets the stage for further advancements in the field of medical image analysis. Additionally, we have built a new dataset, which is now publicly accessible, offering a broader range of classes and variability for future research and development.

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Theory of the Leaky Intestine: Gender Differences in Intestinal Parasitic Infections, Cytoskeletal Wall Dysfunctions, and Hypertension

Njemanze,

Amadi,

Onuchukwu

et al. 2024

Qeios

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BACKGROUND: Intestinal parasitic infections (IPIs) impact approximately 3.5 billion individuals globally. Protozoan IPIs may influence the intestinal microbiome. This research investigates IPI effects on intestinal wall thickness and their potential links to gender-specific hypertension. It also explores the impact of alterations in intestinal wall permeability on sodium and blood glucose levels. METHODS: The study enrolled 108 subjects, including 83 consecutive patients with confirmed symptomatic IPIs (48 males, 35 females) and 25 healthy controls (9 males, 16 females). B-mode ultrasound grayscale images of the duodenum and colon were taken with and without water contrast. RESULTS: Patients with parasites exhibited a higher BMI (mean = 28.98 ± 7.43) compared to controls (mean = 24.68 ± 7.2), F (1, 96) = 5.78, _p _< 0.05. IPI patients showed a tendency towards increased duodenal wall thickness (DUOTHICK = 0.88 ± 0.73 cm) versus controls (0.6 ± 0.1 cm), _p = _0.056. Additionally, IPI patients had significantly greater thickness in the ascending colon (ASCTHICK = 1.1 ± 0.3 cm) and descending colon (DSCTHICK = 1.2 ± 0.4 cm) compared to controls (ASCTHICK = 0.6 ± 0.2 cm, DSCTHICK = 0.6 ± 0.1 cm), _p _< 0.05. Men over 50 years exhibited greater DSCTHICK (1.25 ± 0.434 cm) than postmenopausal women (0.986 ± 0.389 cm), _p _< 0.05. DSCTHICK significantly predicted diastolic blood pressure (β = −0.295, _p _< 0.05) and blood sodium level (β = −0.300, _p _< 0.05). DUOTHICK in diabetic IPI patients exceeded that in nondiabetic patients. Effective antiparasitic and antidiabetic treatments induced changes in the echoanatomy of the intestinal wall, suggesting the sealing of ‘the leak’. CONCLUSIONS: IPIs disrupted the intestinal cytoskeleton, leading to “leaky gut syndrome” development.

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Intestinal parasites and diabetes: A systematic review and meta-analysis

Cited by 5 publications

References 49 publications

The significance of chronic hyperglycemia for the reduced efficacy of eradication therapy in patients with type 2 diabetes mellitus and for Helicobacter pylori survival

The significance of chronic hyperglycemia for the reduced efficacy of eradication therapy in patients with type 2 diabetes mellitus and for Helicobacter pylori survival

Improving faster R-CNN generalization for intestinal parasite detection using cycle-GAN based data augmentation

Theory of the Leaky Intestine: Gender Differences in Intestinal Parasitic Infections, Cytoskeletal Wall Dysfunctions, and Hypertension

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