Intestinal microbiome diversity of diabetic and non-diabetic kidney disease: Current status and future perspective

Das, Soumik; Ramanathan, Gnanasambandan

doi:10.1016/j.lfs.2023.121414

Cited by 5 publications

(3 citation statements)

References 215 publications

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“…In a diabetic context, a shift from glucose to protein metabolism takes place. Thus, PCS is a protein-bound uremic solute that is produced in the small intestine following the phenylalanine-to-p-cresol route [ 34 ]. PCS excretion occurs by glomerular filtration and proximal tubule reabsorption through OAT receptors on the baso-lateral membrane of proximal tubular epithelial cells [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolites Potentially Derived from Gut Microbiota Associated with Podocyte, Proximal Tubule, and Renal and Cerebrovascular Endothelial Damage in Early Diabetic Kidney Disease in T2DM Patients

Balint

Socaciu

et al. 2023

Metabolites

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Complications due to type 2 diabetes mellitus (T2DM) such as diabetic kidney disease (DKD) and cerebral small vessel disease (CSVD) have a powerful impact on mortality and morbidity. Our current diagnostic markers have become outdated as T2DM-related complications continue to develop. The aim of the investigation was to point out the relationship between previously selected metabolites which are potentially derived from gut microbiota and indicators of endothelial, proximal tubule (PT), and podocyte dysfunction, and neurosonological indices. The study participants were 20 healthy controls and 90 T2DM patients divided into three stages: normoalbuminuria, microalbuminuria, and macroalbuminuria. Serum and urine metabolites were determined by untargeted and targeted metabolomic techniques. The markers of endothelial, PT and podocyte dysfunction were assessed by ELISA technique, and the neurosonological indices were provided by an ultrasound device with high resolution (MYLAB 8-ESAOTE Italy). The descriptive statistical analysis was followed by univariable and multivariable linear regression analyses. In conclusion, in serum, arginine (sArg), butenoylcarnitine (sBCA), and indoxyl sulfate (sIS) expressed a biomarker potential in terms of renal endothelial dysfunction and carotid atherosclerosis, whereas sorbitol (sSorb) may be a potential biomarker of blood–brain barrier (BBB) dysfunction. In urine, BCA and IS were associated with markers of podocyte damage, whereas PCS correlated with markers of PT dysfunction.

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Section: Discussionmentioning

confidence: 99%

Metabolites Potentially Derived from Gut Microbiota Associated with Podocyte, Proximal Tubule, and Renal and Cerebrovascular Endothelial Damage in Early Diabetic Kidney Disease in T2DM Patients

Balint

Socaciu

et al. 2023

Metabolites

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“…The research has revealed that the reduced abundance of Akkermansia muciniphila in T2D patients may be associated with blood glucose fluctuations. Das et al (2023) [ 19 ] has suggested the identification of novel biomarkers for early detection of diabetic kidney disease (DKD), as well as potential therapies to modulate the gut microbiota and improve host immune response. Ye et al (2023) [ 20 ] has identified the inadequacy of circulating dopamine, imbalanced short-chain fatty acid (SCFA) production, and excessive metabolic inflammation as multiple parallel impacts driven by the gut microbiota in the development of gestational diabetes mellitus (GDM).…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics analysis of the diversity of gut microbiota and different microbiota on insulin resistance in diabetes mellitus patients

Guo

2023

Heliyon

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“…Экспериментальное удаление УТ, в том числе низкомолекулярных (фосфат, триметиламин-N-оксид), крупномолекулярных (фактор роста фибробластов-23, цитокины -ИЛ-1, 6 и 18, ФНО-α и конечные продукты повышенного гликирования белков) и связанных с белками УТ (ИС, п-крезилсульфат -п-КС), уменьшает выраженность КС [9]. Ряд недавних исследований показал, что воздействие ФНО-α, ИЛ-6, ИЛ-18 и интерферона индуцирует кальцификацию КГМС на клеточных моделях и что данный процесс обратим при противовоспалительном лечении [10,11]. Совокупное воздействие крупномолекулярных УТ объясняет повышенный риск васкулопатии, особенно КC, наблюдаемой у пациентов с ХБП и ТПН [12].…”

Section: Discussionunclassified

Clinical significance of uremic toxin indoxyl sulfate and inflammation in the development of vascular calcification and cardiovascular complications in stage C3–C5D chronic kidney disease

Dzgoeva,

Remizov,

Goloeva

et al. 2023

Terapevticheskii arkhiv

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Aim. To clarify the role of the uremic toxin indoxyl sulfate (IS) and inflammation in the development of vascular calcification and cardiovascular complications in chronic kidney disease (CKD). Materials and methods. One hundred fifteen patients aged 25 to 68 years with CKD stage C3C5D were examined. Serum concentrations of IS, interleukin 6 (IL-6), tumor necrosis factor (TNF-), troponin I, parathyroid hormone were determined by enzyme immunoassay using kits from BluGene biotech (Shanghai, China), Cloud-Clone Corp. (USA), ELISA Kit (Biomedica, Austria). Results. An increase in the serum concentration of IS, IL-6, TNF- was revealed, which was significantly associated with a deterioration in renal function and changes in the morphological and functional parameters of the heart and aorta. Conclusion. High concentrations of IS, IL-6, TNF-, which are closely associated with an increase in renal failure and cardiovascular complications, indicate their significant role in vascular calcification, which underlies the damage to the cardiovascular system in CKD.

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Intestinal microbiome diversity of diabetic and non-diabetic kidney disease: Current status and future perspective

Cited by 5 publications

References 215 publications

Metabolites Potentially Derived from Gut Microbiota Associated with Podocyte, Proximal Tubule, and Renal and Cerebrovascular Endothelial Damage in Early Diabetic Kidney Disease in T2DM Patients

Metabolites Potentially Derived from Gut Microbiota Associated with Podocyte, Proximal Tubule, and Renal and Cerebrovascular Endothelial Damage in Early Diabetic Kidney Disease in T2DM Patients

Bioinformatics analysis of the diversity of gut microbiota and different microbiota on insulin resistance in diabetes mellitus patients

Clinical significance of uremic toxin indoxyl sulfate and inflammation in the development of vascular calcification and cardiovascular complications in stage C3–C5D chronic kidney disease

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