Intestinal Lymphangiectasis and Lipidosis in Rats Following Subchronic Exposure to Indole-3-Carbinol via Oral Gavage

Boyle, Michael C.; Crabbs, Torrie A.; Wyde, Michael E.; Painter, Jacob T.; Hill, Georgette D.; Malarkey, David E.; Lieuallen, Warren G.; Nyska, Abraham

doi:10.1177/0192623311436178

Cited by 11 publications

(7 citation statements)

References 60 publications

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“…7 ). However, lacteal dilatation is not commonly observed in rats (Boyle et al 2012 ), and the incidence and severity of lesions were dose dependent. In addition, it is judged to be the effect of BPF on the function of the lymphatic vessels to absorb fat-soluble nutrients, the prolongation of the PT affected by fat-soluble vitamin-related coagulation factors, and the decrease in the blood CHO level.…”

Section: Discussionmentioning

confidence: 98%

Pharmacokinetics and toxicity evaluation following oral exposure to bisphenol F

Lee

Kim

et al. 2022

Arch Toxicol

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Bisphenol F is a substitute material for bisphenol A and is widely used in household products as a raw material for polycarbonate resin, epoxy resin, and plastic reinforcement. It is known to be mainly used in food containers, thermal paper for receipts, and coatings for water pipes. In some countries, bisphenol F has been detected in drinking water and human urine samples. However, due to the lack of safety evaluation data on bisphenol F, it is difficult to establish appropriate guidelines for the proper use of the substance, and social anxiety is increasing accordingly. This study investigated the use, exposure route, and distribution flow of bisphenol F, a household chemical. To determine the no-observed-adverse-effect level (NOAEL) and target organ of bisphenol F after exposure, a single-dose oral toxicity, dose-range finding (28 day oral), repeated dose toxicity (90 day oral), and genotoxicity (reverse mutation, chromosomal abnormality, in vivo micronucleus test) tests were performed. The pharmacokinetic profile was also obtained. The test results are as follows: in the pharmacokinetic study, it was confirmed that single oral exposure to BPF resulted in systemic exposure; in single oral dose toxicity test, the approximate lethal dose was found to be 4000 mg/kg and confusion and convulsion was shown in the test animals; NOAEL was determined to be 2 mg/kg/day for male and 5 mg/kg/day for female, and the no-observed-effect level (NOEL) was determined to be 2 mg/kg/day for males and 1 mg/kg/day for females, and the target organ was the small intestine; genotoxicity tests confirmed that BPF does not induce genotoxicity.

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Section: Discussionmentioning

confidence: 98%

Pharmacokinetics and toxicity evaluation following oral exposure to bisphenol F

Lee

Kim

et al. 2022

Arch Toxicol

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“…neoplasia, fibrosis, granulomatous infections. Lymphangiectasis in the small intestine due to the accumulation of large lipid droplets was described in rats administered indole-3-carbinol, possibly due to an impairment of lipid transport in the lacteals ( Boyle et al 2012 ). Although there were vacuolated macrophages and giant cells in the lamina propria, the epithelial cells were unaffected ( Boyle et al 2012 ).…”

Section: Intestine Small / Largementioning

confidence: 99%

Nonproliferative and Proliferative Lesions ofthe Gastrointestinal Tract, Pancreas andSalivary Glands of the Rat and Mouse

et al. 2016

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) project is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature and diagnostic criteria for nonproliferative and proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and diagnostic criteria for classifying lesions in the digestive system including the salivary glands and the exocrine pancreas of laboratory rats and mice. Most lesions are illustrated by color photomicrographs. The standardized nomenclature, the diagnostic criteria, and the photomicrographs are also available electronically on the Internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and age related lesions as well as lesions induced by exposure to test items. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature and diagnostic criteria for the digestive system will decrease misunderstandings among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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“…A similar histological finding was described in an NTP study of Fischer 344 (F344/N) rats administered indole-3-carbinol via oral gavage. 157 These animals demonstrated a dose-related dilatation of lymphatics (lymphangiectasis) of the duodenum, jejunum, and mesenteric lymph nodes. Material within dilated lacteals stained with Oil Red O and Sudan black, consistent with lipid accumulation.…”

Section: Discussionmentioning

confidence: 95%

NTP Technical Report on the Toxicity Studies of Trans-resveratrol (CASRN 501-36-0) Administered by Gavage for Two Weeks or Three Months to F344/NTac Rats, Wistar Han [Crl:WI(Han)] Rats, and B6C3F1/N Mice

2021

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Trans-resveratrol (RES) is a polyphenol found in various fruits and plants. Numerous in vitro studies have shown its clear antioxidant and anti-inflammatory effects, which has led to additional in vivo and clinical studies evaluating the use of RES to treat diseases such as cancer, cardiometabolic disease, and neurodegenerative disease. Despite growing interest in and use of RES, limited studies have assessed the safety of RES exposure, especially perinatally. The National Toxicology Program conducted toxicity studies to provide these data. Regulatory StatusRES available in dietary supplements is regulated under the U.S. Food, Drug, and Cosmetic Act. Manufacturers and distributors must notify the Food and Drug Administration when they plan to market dietary supplements that contain "new dietary ingredients" (Section 413b of the Act,

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Intestinal Lymphangiectasis and Lipidosis in Rats Following Subchronic Exposure to Indole-3-Carbinol via Oral Gavage

Cited by 11 publications

References 60 publications

Pharmacokinetics and toxicity evaluation following oral exposure to bisphenol F

Pharmacokinetics and toxicity evaluation following oral exposure to bisphenol F

Nonproliferative and Proliferative Lesions ofthe Gastrointestinal Tract, Pancreas andSalivary Glands of the Rat and Mouse

NTP Technical Report on the Toxicity Studies of Trans-resveratrol (CASRN 501-36-0) Administered by Gavage for Two Weeks or Three Months to F344/NTac Rats, Wistar Han [Crl:WI(Han)] Rats, and B6C3F1/N Mice

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