Intestinal Flora Composition and Exploration of New Therapeutic Methods in Children with Autism

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social communication impairments, narrow range of interests or activities, and repetitive behaviors. Early diagnosis and early intervention can achieve better prognostic effects. Many studies have shown that the occurrence and development of ASD is closely related to intestinal flora disorder, which leads to an extremely increased probability of gastrointestinal symptoms in autism children. In addition, intestinal flora disorder in early life may pose a certain threat for infants, including early colonization of microorganisms and early antibiotic administration. Meanwhile, intestinal flora disorder in autistic children also change short-chain fatty acids, amino acids, neurotransmitters in blood. This review focuses on the above points and the possible new methods for the treatment of ASD, expecting to provide new ideas for the treatment of autistic children in addition to behavioral intervention.