Intestinal fatty acid-binding protein is a useful diagnostic marker for mesenteric infarction in humans

Kanda, Tatsuo; Fujii, Hiroshi; Tani, Tadaaki; Murakami, Hiroshi; Suda, Takeyasu; Sakai, Yasuo; Ono, Teruo; Hatakeyama, Katsuyoshi

doi:10.1053/gast.1996.v110.pm8566578

Cited by 238 publications

(162 citation statements)

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“…Apart from computerized tomography, no reliable diagnostic test for intestinal strangulation is currently available, that is costy and not reproducible 8 .…”

Section: Introductionmentioning

confidence: 99%

Bacterial translocation in an experimental intestinal obstruction model: C-reactive protein reliability?

et al. 2009

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Background: Bacterial translocation occurs in preseptic conditions such as intestinal obstruction through unclear mechanism. The C-reactive protein is an acute phase reactant and a marker of ischemia. Methods: 45 albino male rats were divided into 3 groups each 15 rats. GI control, GII simple intestinal-obstruction and GIII strangulated obstruction. Outcome measures were: (1) Bacteriologic count and typing for intestinal contents, intestinal wall, liver, mesenteric lymph nodes and blood (cardiac and portal) (2) Histopathologic: mucosal injury score, inflammatory cell infiltrate in the wall, MLN, liver, (3) Biochemical: serum CRP, IL-10, mucosal stress pattern (glutathione peroxidase-malonyldialdhyde tissue levels). Results: (1) Intestinal obstruction associates with BT precursors (Bact-overgrowth, mucosal-acidosis, immuno-incomptence), (2) Bacterial translocation (frequency and density) was found higher in strangulated I.O, that was mainly enteric (aerobic and anaerobic) and mostly E.coli, (3) The pathogen commonality supports the gut origin hypothesis but the systemic inflammatory response goes with the cytokine generating one. (4) The CRP median values for GI, II, III were 0.5, 6.9, 8.5 mg/L, for BT +ve 8 mg/L and 0.75 mg/L for BT -ve rats. Conclusion: Bacterial translocation occurs bi-directional (systemic-portal) in intestinal obstruction and the resultant inflammatory response pathogenesis is mostly 3 hit model. The CRP is a non selective marker of suspected I.O cases. However, it is a reliable marker of BT, BT density and vascular compromise during I.O. Key words: Intestinal Obstruction. Ischemia. Bacterial Translocation. Rats. RESUMO Objetivo:Translocação bacteriana ocorre em condições pré-sépticas como na obstrução intestinal por mecanismo não esclarecido. A proteína C-reativa é um marcador de ischemia em fase aguda. A proposição é investigar os possíveis efeitos da obstrução intestinal no equilíbrio ecológico microbiano. Métodos: 45 ratos machos albinos foram distribuídos em três grupos de 15 ratos. GI controle, GII obstrução intestinal simples e GIII obstrução estrangulada. As medidas adotadas foram: (1) Contagem bacteriológica do conteúdo intestinal, parede intestinal, fígado, linfonodos mesentéricos e sangue (coração e portal) (2) Avaliação histopatológica da lesão da mucosa, infiltrado celular inflamatório da parede, linfonodos mesentéricos, fígado, (3) Avaliação bioquímica. Resultados: (1) Obstrução intestinal está associada a precursora translocação bacteriana (crescimento bacteriano, acidose da mucosa, imuno-incompetência), (2) Translocação bacteriana (freqüência e densidade) foi maior na obstrução intestinal estrangulada, principalmente entérica (aeróbios e anaeróbios), sobretudo E.coli, (3) A ocorrência comum é de origem intestinal. Conclusão: A translocação bacteriana na obstrução intestinal é bi-direcional (sistêmica e portal) A proteina C-reativa não é um marcador seletivo na suspeita de obstrução intestinal. Contudo é marcador confiável da translocação bacteriana, na densidade e com...

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“…Apart from computerized tomography, no reliable diagnostic test for intestinal strangulation is currently available, that is costy and not reproducible 8 .…”

Section: Introductionmentioning

confidence: 99%

Bacterial translocation in an experimental intestinal obstruction model: C-reactive protein reliability?

et al. 2009

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“…Ultrasonography (US) and computer tomography (CT) are promising tools, but their definitive role in the diagnosis of strangulated obstruction has still to be established (16)(17)(18)(19). Some biochemical markers have been used for the diagnosis of mesenteric ischemia (20)(21)(22). However, further studies are needed to confirm validity of these markers in cases with strangulated obstruction.…”

Section: Introductionmentioning

confidence: 99%

The role of D-dimer in the diagnosis of strangulated small-bowel obstruction

Boguševičius¹,

Grinkevičius²,

Maleckas³

et al. 2007

Medicina

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“…A vékonybél ischaemiás toleranciája 6 óra, ezt követően irreverzibilisen károsodik, ezért a korai diagnózis létfon-tosságú. Néhány humán vizsgálat során sikerült igazolni, hogy a szérum-I-FABP szintje megemelkedik az arteria mesenterica superior occlusiója esetén [8,15,[18][19][20][21]. Egy patkányokat használó kísérletes modellben az SE I. Sebészeti Klinika munkacsoportja kimutatta, hogy a szé-rum-I-FABP szintjének emelkedése jól korrelál a szövet-tani minták elemzése során talált intestinalis epithelsejtkárosodás mértékével [22].…”

Section: Nekrotizáló Enterocolitis Akut Mesenterialis Ischaemiaunclassified

Intestinalis zsírsavkötő fehérje: az enterocytakárosodás markere akut és krónikus gasztroenterológiai kórképekben

et al. 2016

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DebrecenAz intestinalis zsírsavkötő fehérje a zsírsavkötő fehérjék családjába tartozó, a vékony-és vastagbél enterocytáinak citoszoljában termelődő, kis molekulasúlyú fehérje. Az enterocytasejtek membránintegritásának megbomlását köve-tően megjelenik a szisztémás keringésben, és a vesék glomerularis szűrőjén keresztül kiválasztódik a vizeletbe. A szerzők akut és krónikus enterocytakárosodással járó gastrointestinalis kórképekben az intestinalis zsírsavkötő fehérje biomarkerként való használatával kapcsolatos vizsgálatokat tekintik át. Orv. Hetil., 2016, 157(2), 59-64.Kulcsszavak: intestinalis zsírsavkötő fehérje, nekrotizáló enterocolitis, akut mesenterialis ischaemia, coeliakia, gyulladásos bélbetegség, bakteriális transzlokáció Intestinal fatty acid binding protein: marker of enterocyte damage in acute and chronic gastroenterological diseasesIntestinal fatty acid binding protein, a small cytosolic protein abundantly present in mature enterocytes of small and large intestine, has proven to be a sensitive marker for damage to the intestinal epithelium. Upon cellular damage of the enterocyte, intestinal fatty acid binding protein is readily released into the systemic circulation, passes through the glomerular fi lter and can be detected in the urine. In this review, the authors review studies on the application of this protein as a biomarker in acute and chronic gastrointestinal diseases.

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Intestinal fatty acid-binding protein is a useful diagnostic marker for mesenteric infarction in humans

Cited by 238 publications

References 3 publications

Bacterial translocation in an experimental intestinal obstruction model: C-reactive protein reliability?

Bacterial translocation in an experimental intestinal obstruction model: C-reactive protein reliability?

The role of D-dimer in the diagnosis of strangulated small-bowel obstruction

Intestinalis zsírsavkötő fehérje: az enterocytakárosodás markere akut és krónikus gasztroenterológiai kórképekben

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