Intestinal dendritic cell and macrophage subsets: Tipping the balance to Crohn's Disease?

Magnusson, Maria K.; Wick, Mary Jo

doi:10.1556/eujmi.1.2011.1.5

Cited by 4 publications

(5 citation statements)

References 55 publications

(100 reference statements)

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“…A number of studies (33–42) indicate that the plant kingdom provides not only nutrients but also bioactive natural products to prevent diseases that occur in the mammalian kingdom. How plant‐derived bioactive natural products execute their functions on the mammalian system while resisting the harsh GI environment, that is, the low pH in the stomach and the degradative enzymes, and more importantly, how plant‐derived bioactive natural products which are a foreign material to the mammalian immune system are ignored by immune cells is not well understood.…”

Section: Discussionmentioning

confidence: 99%

Ginger‐derived nanoparticles protect against alcohol‐induced liver damage

Zhuang

Deng

et al. 2015

J of Extracellular Vesicle

330

353

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Daily exposure of humans to nanoparticles from edible plants is inevitable, but significant advances are required to determine whether edible plant nanoparticles are beneficial to our health. Additionally, strategies are needed to elucidate the molecular mechanisms underlying any beneficial effects. Here, as a proof of concept, we used a mouse model to show that orally given nanoparticles isolated from ginger extracts using a sucrose gradient centrifugation procedure resulted in protecting mice against alcohol-induced liver damage. The ginger-derived nanoparticle (GDN)–mediated activation of nuclear factor erythroid 2-related factor 2 (Nrf2) led to the expression of a group of liver detoxifying/antioxidant genes and inhibited the production of reactive oxygen species, which partially contributes to the liver protection. Using lipid knock-out and knock-in strategies, we further identified that shogaol in the GDN plays a role in the induction of Nrf2 in a TLR4/TRIF-dependent manner. Given the critical role of Nrf2 in modulating numerous cellular processes, including hepatocyte homeostasis, drug metabolism, antioxidant defenses, and cell-cycle progression of liver, this finding not only opens up a new avenue for investigating GDN as a means to protect against the development of liver-related diseases such as alcohol-induced liver damage but sheds light on studying the cellular and molecular mechanisms underlying interspecies communication in the liver via edible plant–derived nanoparticles.

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Section: Discussionmentioning

confidence: 99%

Ginger‐derived nanoparticles protect against alcohol‐induced liver damage

Zhuang

Deng

et al. 2015

J of Extracellular Vesicle

330

353

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“…Both gut microbiota and food‐derived antigens alter intestinal DCs function, and contribute to a loss of tolerance and to induction and progression of IBD 19 . In patients with IBD, the tolerance/immunity balance is disturbed, leading to chronic intestinal inflammation driven by aberrant T‐cell reactivity to intestinal bacteria 36 . Tolerogenic DCs act by promoting differentiation and expansion of Tregs that efficiently modulate gut inflammation, and they are disturbed in IBD 37 …”

Section: Subsets Of Cells Involved In the Immune Responsementioning

confidence: 99%

“…19 In patients with IBD, the tolerance/immunity balance is disturbed, leading to chronic intestinal inflammation driven by aberrant T-cell reactivity to intestinal bacteria. 36 Tolerogenic DCs act by promoting differentiation and expansion of Tregs that efficiently modulate gut inflammation, and they are disturbed in IBD. 37 (vii) NKT cells are a subset of non-conventional T cells recognizing endogenous and/or exogenous glycolipid antigens when presented by the major histocompatibility complex class I-like antigen-presenting molecules CD1d.…”

Section: Subsets Of Cells Involved In the Immune Responsementioning

confidence: 99%

Oral immune therapy: targeting the systemic immune system via the gut immune system for the treatment of inflammatory bowel disease

Ilan

2016

Clin & Trans Imm

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Inflammatory bowel diseases (IBD) are associated with an altered systemic immune response leading to inflammation-mediated damage to the gut and other organs. Oral immune therapy is a method of systemic immune modulation via alteration of the gut immune system. It uses the inherit ability of the innate system of the gut to redirect the systemic innate and adaptive immune responses. Oral immune therapy is an attractive clinical approach to treat autoimmune and inflammatory disorders. It can induce immune modulation without immune suppression, has minimal toxicity and is easily administered. Targeting the systemic immune system via the gut immune system can serve as an attractive novel therapeutic method for IBD. This review summarizes the current data and discusses several examples of oral immune therapeutic methods for using the gut immune system to generate signals to reset systemic immunity as a treatment for IBD.

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“…In addition, cells were positive for CD11b, CD14, Sirpα, and CD16. These cells are phenotypically similar to immature monocyte‐derived DCs [50, 51] and/or CD14 + CD209 + macrophages [52]. Compared to control cells, E/G/M‐generated cells revealed dramatically lower percentages of cells assigned to clusters 5 and 8, exhibiting monocyte characteristics.…”

Section: Resultsmentioning

confidence: 99%

A novel 3D cell culture model to study the human small intestinal immune landscape

et al. 2023

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Several subsets of mononuclear phagocytes and DCs (MDC) populate the small intestine (SI), and these cells reportedly exert specialized functions in anti-microbial immunity and tolerance. Given the specialized phenotype of these cells, differing from other MDC family members, including their putative circulating blood precursors, local intestinal factors play key instructive roles in their differentiation. We designed an SI cell culture model composed of three intestinal epithelial cell (IEC) types, including absorptive enterocytes (E cells), antigen delivering microfold (M) cells, and mucus-producing goblet (G) cells plus T lymphocytes and soluble B cell-derived factors. This model was used to study the differentiation fate of CD34 + hematopoietic progenitor cell-derived monocyte/DC precursors. Progeny cells can be analyzed after a 3-week co-culture period, mimicking the physiologic turn-over time of intestinal MDC. A dominant monocyte differentiation pathway was suppressed, in favor of partial differentiation along DC and macrophage pathways, with low percentages of cells acquired DC or macrophage markers. Moreover, E and G cells play opposing roles in CX3CR1 + vs CD103 dim cell differentiation, indicating that both together might counter-balance M/DC differentiation. Thus, SI epithelial cells suppress M/DC differentiation, supporting a key role for exogenous factors in M/DC differentiation.

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Intestinal dendritic cell and macrophage subsets: Tipping the balance to Crohn's Disease?

Cited by 4 publications

References 55 publications

Ginger‐derived nanoparticles protect against alcohol‐induced liver damage

Ginger‐derived nanoparticles protect against alcohol‐induced liver damage

Oral immune therapy: targeting the systemic immune system via the gut immune system for the treatment of inflammatory bowel disease

A novel 3D cell culture model to study the human small intestinal immune landscape

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