Intestinal barrier disruption and dysregulated mucosal immunity contribute to kidney fibrosis in chronic kidney disease

Yang, Jihyun; Lim, Sung Yoon; Ko, Yoon Sook; Lee, Hee Young; Oh, Se Won; Kim, Myung Gyu; Cho, Won Yong; Jo, Sang Kyung

doi:10.1093/ndt/gfy172

Cited by 87 publications

(85 citation statements)

References 39 publications

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“…Intestinal dysbiosis also occurs in chronic kidney disease (CKD) [139,140] and might actively contribute to the progression of renal failure [141,142]. The main signature of CKD dysbiosis is increased Proteobacteria [143], although increased Lachnospiraceae is also observed [140,144] (Table 2).…”

Section: Kidney Diseasesmentioning

confidence: 99%

The Controversial Role of Human Gut Lachnospiraceae

et al. 2020

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The complex polymicrobial composition of human gut microbiota plays a key role in health and disease. Lachnospiraceae belong to the core of gut microbiota, colonizing the intestinal lumen from birth and increasing, in terms of species richness and their relative abundances during the host’s life. Although, members of Lachnospiraceae are among the main producers of short-chain fatty acids, different taxa of Lachnospiraceae are also associated with different intra- and extraintestinal diseases. Their impact on the host physiology is often inconsistent across different studies. Here, we discuss changes in Lachnospiraceae abundances according to health and disease. With the aim of harnessing Lachnospiraceae to promote human health, we also analyze how nutrients from the host diet can influence their growth and how their metabolites can, in turn, influence host physiology.

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Section: Kidney Diseasesmentioning

confidence: 99%

The Controversial Role of Human Gut Lachnospiraceae

et al. 2020

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“…C hanges in intestinal permeability and the intestinal microbiome have been associated with many diseases. [1][2][3][4][5] Intestinal physiology can vary, even among genetically identical animals. 6 Due to the close anatomical and physiologic connections between the intestine and the liver, there have been many studies of how changes in one affect the other.…”

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confidence: 99%

Contribution of the Intestinal Microbiome and Gut Barrier to Hepatic Disorders

2020

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Intestinal barrier dysfunction and dysbiosis contribute to development of diseases in liver and other organs. Physical, immunologic, and microbiologic (bacterial, fungal, archaeal, viral, and protozoal) features of the intestine separate its nearly 100 trillion microbes from the rest of the human body. Failure of any aspect of this barrier can result in translocation of microbes into the blood and sustained inflammatory response that promote liver injury, fibrosis, cirrhosis, and oncogenic transformation. Alterations in intestinal microbial populations or their functions can also affect health. We review the mechanisms that regulate intestinal permeability and how changes in the intestinal microbiome contribute to development of acute and chronic liver diseases. We discuss individual components of the intestinal barrier and how these are disrupted during development of different liver diseases. Learning more about these processes will increase our understanding of the interactions among the liver, intestine, and its flora.

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“…[31][32][33] The mucosal microbiota has close interactions with intestinal epithelial cells, as well as those of the immune system, and may have relevance for the integrity of the gastrointestinal barrier. In experimental animal models of CKD, it has been shown that gastrointestinal permeability is increased with CKD, [34][35][36] and markers of intestinal permeability are inversely correlated with estimated glomerular filtration rate in patients with CKD. 37,38 Of practical relevance for patients is that an endoscopy is required for obtaining mucosa-associated microbes.…”

Section: Sampling and Processing Effectsmentioning

confidence: 99%

A Renal Clinician's Guide to the Gut Microbiota

Snelson

Biruete

McFarlane

et al. 2020

Journal of Renal Nutrition

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It is increasingly recognized that the gut microbiota plays a role in the progression of chronic diseases and that diet may confer health benefits by altering the gut microbiota composition. This is of particular relevance for chronic kidney disease (CKD), as the gut is a source of uremic retention solutes, which accumulate as a result of impaired kidney function and can exert nephrotoxic and other harmful effects. Kidney dysfunction is also associated with changes in the composition of the gut microbiota and the gastrointestinal tract. Diet modulates the gut microbiota, and there is much interest in the use of prebiotics, probiotics, and synbiotics as dietary therapies in CKD, as well as dietary patterns that beneficially alter the microbiota. This review provides an overview of the gut microbiota and its measurement, its relevance in the context of CKD, and the current state of knowledge regarding dietary manipulation of the microbiota.

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Intestinal barrier disruption and dysregulated mucosal immunity contribute to kidney fibrosis in chronic kidney disease

Abstract: Our results suggest that intestinal dysbiosis-associated gut barrier disruption and aberrant mucosal immunity are important for the systemic inflammation and progressive fibrosis of CKD. Targeting the intestine might provide novel therapeutic opportunities for CKD.

Cited by 87 publications

References 39 publications

The Controversial Role of Human Gut Lachnospiraceae

The Controversial Role of Human Gut Lachnospiraceae

Contribution of the Intestinal Microbiome and Gut Barrier to Hepatic Disorders

A Renal Clinician's Guide to the Gut Microbiota

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