The Controversial Role of Human Gut Lachnospiraceae

Vacca, Mirco; Celano, Giuseppe; Calabrese, Francesco Maria; Portincasa, Piero; Gobbetti, Marco; Angelis, Maria De

doi:10.3390/microorganisms8040573

Cited by 962 publications

(863 citation statements)

References 204 publications

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“…Many Lachnospiraceae members have been detected in the human intestine [ 48 ] and some exhibit important hydrolytic activities (e.g., xylanase, β-xylosidase β-galactosidase, α- and β-glucosidase, α-amylase, pectin methyl-esterase, pectate lyase, N-acetyl-β-glucosaminidase) [ 49 ]. Lower amounts of Lachnospiraceae were previously reported in a subject suffering from UC [ 50 ], however, Vacca et al [ 51 ] pointed out the increased abundance of Lachnospiraceae in the intestinal lumen of subjects with different diseases, thus indicating the possible controversial role of this taxon. Nevertheless, several genera are known for their positive effect on health, especially butyrate-producing strains of Butyrivibrio , Roseburia , Anaerostipes , or Coprococcus [ 52 ].…”

Section: Discussionmentioning

confidence: 92%

Gut Microbiome Changes in Patients with Active Left-Sided Ulcerative Colitis after Fecal Microbiome Transplantation and Topical 5-aminosalicylic Acid Therapy

Schierová

Březina

Mrázek

et al. 2020

Cells

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Ulcerative colitis (UC) is an inflammatory bowel disease, and intestinal bacteria are implicated in the pathogenesis of this disorder. The administration of aminosalicylates (5-ASA) is a conventional treatment that targets the mucosa, while fecal microbial transplantation (FMT) is a novel treatment that directly targets the gut microbiota. The aim of this study was to identify changes in fecal bacterial composition after both types of treatments and evaluate clinical responses. Sixteen patients with active left-sided UC underwent enema treatment using 5-ASA (n = 8) or FMT (n = 8) with a stool from a single donor. Fecal microbiota were analyzed by 16S rDNA high-throughput sequencing, and clinical indices were used to assess the efficacy of treatments. 5-ASA therapy resulted in clinical remission in 50% (4/8) of patients, but no correlation with changes in fecal bacteria was observed. In FMT, remission was achieved in 37.5% (3/8) of patients and was associated with a significantly increased relative abundance of the families Lachnospiraceae, Ruminococcaceae, and Clostridiaceae of the phylum Firmicutes, and Bifidobacteriaceae and Coriobacteriaceae of the phylum Actinobacteria. At the genus level, Faecalibacterium, Blautia, Coriobacteria, Collinsela, Slackia, and Bifidobacterium were significantly more frequent in patients who reached clinical remission. However, the increased abundance of beneficial taxa was not a sufficient factor to achieve clinical improvement in all UC patients. Nevertheless, our preliminary results indicate that FMT as non-drug-using method is thought to be a promising treatment for UC patients.

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Section: Discussionmentioning

confidence: 92%

Gut Microbiome Changes in Patients with Active Left-Sided Ulcerative Colitis after Fecal Microbiome Transplantation and Topical 5-aminosalicylic Acid Therapy

Schierová

Březina

Mrázek

et al. 2020

Cells

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“…These findings are also in agreement with previous reports showing negative correlations of the genera Ruminococcaceae NK4A214 and Lachnospiraceae NK4A136 groups with HFD consumption [ 79 , 80 ]. One of the vital functions of Ruminococcaceae and Lachnospiraceae produced short-chain fatty acids (SCFA), such as butyric acid and acetic acid [ 81 , 82 ]. SCFA plays an important role in maintaining a healthy condition because they may minimize the risk of many diseases, including type 2 diabetes and obesity [ 83 ].…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Newly Isolated Akkermansia muciniphila Strains from the Human Gut on Obesity and Metabolic Dysregulation

et al. 2020

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The identification of new probiotics with anti-obesity properties has attracted considerable interest. In the present study, the anti-obesity activities of Akkermansia muciniphila (A. muciniphila) strains isolated from human stool samples and their relationship with the gut microbiota were evaluated using a high fat-diet (HFD)-fed mice model. Three strains of A. muciniphila were chosen from 27 isolates selected based on their anti-lipogenic activity in 3T3-L1 cells. The anti-lipogenic, anti-adipogenic and anti-obesity properties of these three strains were evaluated further in HFD-induced obese mice. The animals were administered these strains six times per week for 12 weeks. The treatment improved the HFD-induced metabolic disorders in mice in terms of the prevention of body weight gain, caloric intake and reduction in the weights of the major adipose tissues and total fat. In addition, it improved glucose homeostasis and insulin sensitivity. These effects were also associated with the inhibition of low-grade intestinal inflammation and restoration of damaged gut integrity, prevention of liver steatosis and improvement of hepatic function. These results revealed a difference in the distribution pattern of the gut microbial communities between groups. Therefore, the gut microbial population modulation, at least in part, might contribute to the beneficial impact of the selected A. muciniphila strains against metabolic disorders.

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“…It has been shown to be creatinine [ 63 ]. Other studies have also shown that intestinal dysbiosis occurs in CKD and can actively contribute to the progression of renal failure [ 64 ]. The main characteristic of CKD dysbiosis is an increase in Proteobacteria [ 65 ], but an increase in Lachnospiraceae has also been observed [ 66 , 67 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Altered Blood Parameters and Gut Microbiota after Synbiotic Intake in Healthy, Elderly Korean Women

et al. 2020

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Synbiotics intake can alter the composition of intestinal microbes beneficially. We aimed to detect the changes in the intestinal microbiomes of 37 healthy elderly Korean women after the intake of a synbiotic drink. This was a longitudinal study controlled with a temporal series, including a control period of 3 weeks before intake, synbiotic intake for 3 weeks, and a washout period of 3 weeks. Fecal microbiota composition was analyzed by sequencing the V3-V4 hypervariable regions of 16S rRNA. Physical fecal activity increased with improvement in fecal shape. Thirty intestinal bacterial taxa were observed to change only after the intake period. In particular, Ellagibacter appeared only after ingestion. In addition, the abundance of Terrisporobacter showed a positive correlation with C-reactive protein, triglyceride. Lachnospiraceae_uc, Eubacterium_g5, and Blautia had a positive correlation with creatinine, whereas PAC001100_g had a negative correlation with creatinine. Short-term (3 weeks) intake of symbiotic organisms changes the composition of the gut microbiota in healthy elderly Korean women.

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The Controversial Role of Human Gut Lachnospiraceae

Cited by 962 publications

References 204 publications

Gut Microbiome Changes in Patients with Active Left-Sided Ulcerative Colitis after Fecal Microbiome Transplantation and Topical 5-aminosalicylic Acid Therapy

Gut Microbiome Changes in Patients with Active Left-Sided Ulcerative Colitis after Fecal Microbiome Transplantation and Topical 5-aminosalicylic Acid Therapy

Beneficial Effects of Newly Isolated Akkermansia muciniphila Strains from the Human Gut on Obesity and Metabolic Dysregulation

Association between Altered Blood Parameters and Gut Microbiota after Synbiotic Intake in Healthy, Elderly Korean Women

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