Intestinal alkaline phosphatase in patients with chronic renal failure

Alpers, David H.; DeSchryver-Kecskemeti, K; Goodwin, Carol L.; Tindira, Carol A.; Harter, Herschel R.; Slatopolsky, Eduardo

doi:10.1016/0016-5085(88)90610-5

Cited by 21 publications

(13 citation statements)

References 18 publications

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“…elevated levels of intestinal ALP in patients with renal impairment have been reported (Alpers et al, 1988;Travis et al, 1995). As expected, in this study, treatment of mice with the CTX caused marked elevations in serum ALP, AST, and ALT.…”

Section: Discussionsupporting

confidence: 87%

Acacia ferrugineainhibits cyclophosphamide-induced immunosuppression and urotoxicity by modulating cytokines in mice

Sakthivel

Guruvayoorappan

2014

Journal of Immunotoxicology

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Cyclophosphamide (CTX), commonly used as an anti-neoplastic drug, can cause adverse sideeffects including immunotoxicity and urotoxicity. Increasingly, plants have become sources of therapeutics that can help to restore host immunity to normal. In this study, Acacia ferruginea was assessed for an ability to protect mice against/mitigate CTX-induced toxicity. Coadministration of an extract of A. ferruginea (10 mg/kg BW, IP daily) for 10 consecutive days reduced CTX (25 mg/kg BW, IP daily)-induced toxicity. Apart from improvements in bladder and small intestine morphology, there was marked improvement in anti-oxidant (glutathione) levels in the bladder, suggesting a role for the anti-oxidant in reducing CTX-induced urotoxicity. Moreover, use of the extract significantly increased total leukocyte counts and bone marrow cellularity/-esterase activity in CTX-treated mice which suggested a protective effect on the hematopoietic system. Co-treatment with the extract also prevented decreases in organ (liver, kidney, spleen, thymus) weight as well as body weight, thereby seemingly lessening the potential impact of CTX on the host immune system. Further, CTX-induced increases in serum aspartate transanimase, alanine transaminase, and alkaline phosphatase were reversed by extract co-treatment, as were alterations in in situ formation/release of interferon (IFN)-, interleukin (IL)-2, granulocyte-macrophage colony stimulating factor (GM-CSF), and tumor necrosis factor (TNF)-. Overall, this study indicated there were some protective effects from use of an extract of A.ferruginea against CTX-induced toxicities, in part through modulation of levels of anti-oxidants and pro-inflammatory cytokines.

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Section: Discussionsupporting

confidence: 87%

Acacia ferrugineainhibits cyclophosphamide-induced immunosuppression and urotoxicity by modulating cytokines in mice

Sakthivel

Guruvayoorappan

2014

Journal of Immunotoxicology

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“…Intestinal alkaline phosphatase has been found in association with renal diseases [7] and even detected in equine and human kid neys [24], Therefore, a higher percentage than normal is expected in a diabetic popu lation where the risk of renal involvement is high. This was not apparent in this study, because only those with normal renal func tion tests were included.…”

Section: Discussionmentioning

confidence: 99%

“…Some workers have shown a correlation between blood glucose and levels of alkaline phosphatase activity [5], while others have found no such correla tion [6]. It has been claimed that the total alkaline phosphatase elevation in diabetes reflects an increase in the bone isoenzyme [5], but more recently interest has been shown in the intestinal isoenzyme because its incidence is reported to increase in chronic renal failure associated with long standing diabetes [7], This study was undertaken to examine the alkaline phosphatase isoenzyme profile of a diabetic Arab population and its relation to the metabolic state.…”

Section: Introductionmentioning

confidence: 99%

Serum Alkaline Phosphatase Isoenzymes in an Arab Population with Non-Insulin-Dependent Diabetes mellitus

Abdella¹,

Barakat²,

Al-Sabbagh³

et al. 1990

Med Principles Pract

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Total serum alkaline phosphatase and its liver, bone and intestinal isoenzymes were estimated in 62 Arab subjects with non-insulin-dependent diabetes mellitus and compared with the levels in 64 healthy controls. A significant elevation of total alkaline phosphatase was found in the diabetic patients (126IU/1) compared to the controls (79 IU/1). The level of the liver alkaline phosphatase isoenzyme fraction was also higher in the diabetic group (84 IU/1) than in the controls (64 IU/1). In addition, the value for the bone isoenzyme fraction, which was the predominant fraction in 16 diabetics and 21 controls, was significantly higher in diabetics (122 IU/1) than in controls (31 IU/1). However, the intestinal alkaline phosphatase band, which was present in 12 diabetics (54IU/1) and 7 healthy controls (42 IU/1), was not significantly different. Both the diabetics and controls with this band had either blood group·or B. Total alkaline phosphatase and the bone isoenzyme were found to correlate positively with fasting blood glucose. Thus, although total alkaline phosphatase and its bone and liver isoenzyme fractions are elevated in diabetic subjects, the level of the intestinal fraction seems to be independent of the diabetic state.

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“…Une activité élevée de PAL peut donc correspondre à une O1 normale ou basse. L'activité élevée des isoformes intestinaux a déjà été décrite précédemment et n'est toujours pas, à notre connaissance, expliquée [14][15][16]. Dans notre étude, l'importante activité des fractions hépatiques de certains de nos patients ne trouve pas non plus d'explication.…”

Section: Les Valeurs Observéesunclassified

Intérêt de l'électrophorèse des isophosphatases alcalines chez l'insuffisant rénal hémodialysé

Gillain¹,

Robin²,

Milet³

et al. 2004

Immuno-analyse & Biologie Spécialisée

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Intestinal alkaline phosphatase in patients with chronic renal failure

Cited by 21 publications

References 18 publications

Acacia ferrugineainhibits cyclophosphamide-induced immunosuppression and urotoxicity by modulating cytokines in mice

Acacia ferrugineainhibits cyclophosphamide-induced immunosuppression and urotoxicity by modulating cytokines in mice

Serum Alkaline Phosphatase Isoenzymes in an Arab Population with Non-Insulin-Dependent Diabetes mellitus

Intérêt de l'électrophorèse des isophosphatases alcalines chez l'insuffisant rénal hémodialysé

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