Intestinal Adenomatosis in a Foal

Abstract

Intestinal Adenomatosis in a Foal G. E. DUHAMEL and E. B. WHEELDONA thin six-month-old male Arabian foal was admitted to the Veterinary Medical Teaching Hospital, University of California, Davis, with a four-day history of anorexia, depression, and copious black feces. It had been at pasture with its mother since birth. One week prior to presentation, it had been wormed with Equivet (Farnam, Phoenix, Ariz.). On presentation, the animal was in lateral recumbency with cold extremities, pale injected mucous membranes, and marked soiling of the perineum and tail. Despite intensive fluid, steroid, and antibiotic therapy, the animal deteriorated rapidly and died twelve hours after presentation.The necropsy was done three hours later and revealed gross lesions in the stomach, small intestine, and kidneys. The entire gastrointestinal tract was filled with green pasty contents, and there were no formed feces in the rectum. The pyloric region of the stomach had several small and two large (3 cm X 1 cm) hemorrhagic ulcers. The wall of the distal duodenum, jejunum, and ileum was thickened irregularly (up to 12 mm) with prominent corrugation of the mucosal surface. An area involving proximal to mid ileum had a scattered segmental distribution of mucosal flattening; here, multiple often confluent nodules, with depressed centers 3 to 7 mm in width and raised a few mm above the flattened mucosal surface, were seen ( fig. I). The large intestine was not involved. Mesenteric lymph nodes were swollen and slightly congested while both kidneys had multiple early cortical infarcts.Tissue blocks were fixed in 10% neutral buffered formalin, embedded in paraffin, and cut at 6 pm. In addition to sections stained with hematoxylin and eosin (HE), sections of intestine were stained further with periodic acid-Schiff (PAS), Levaditi-Manovelian method, BrownBrenn tissue Gram's stain, Giemsa, and Ziehl-Neelsen acid-fast stain. Selected pieces of formalin-fured intestine were post-fixed in osmium tetroxide and embedded in epoxy resin. Thin sections were stained with uranyl acetate and lead citrate.Histologically, the small intestine had extensive irregular thickening of the mucosa due to marked hyperplasia of crypt epithelium. Villous length often was reduced, while intestinal

Proliferative Enteropathy in a Foal Caused by Lawsonia Intracellularis-Like Bacterium

“…Proliferative enteropathy (proliferative enteritis, proliferative ileitis, intestinal adenomatosis) has been reported in several animal species including the pig,1 2 dog, 2 foal, 3 blue fox, 5 guinea pig, 4 ferret, 6 hamster, 7 and rabbit. 13 The disease is characterized by adenomatous hyperplasia of crypt epithelial cells in the ileum and colon with intracytoplasmic curved bacteria resembling Campylobacter species.…”

“…In the single case previously reported in a foal, Campylobacter-like organisms were demonstrated within the cytoplasm of enterocytes by spirochete stains and electron microscopy. 3 In a study using cloned DNA probes to isolated Campylobacter-like organisms, there was failure of the probes to hybridize with common porcine Campylobacter species, suggesting the causative agent to be an unidentified or uncultured species. 8 This finding, along with DNA sequencing and structural characteristics, resulted in this organism being named ileal symbiont intracellularis.…”

Enteropatia proliferativa em eqüinos

“…A faixa etária de potros afetados pode variar de três a nove meses (DUHAMEL & WHEELDON, 1982;WILLIAMS et al, 1996;FRANK et al, 1998;BREES et al, 1999;LAVOIE et al, 2000;SCHUMACHER et al, 2000;LAVOIE & DROLET, 2002;WUERSCH et al, 2006). Porém, este fato não comprova a associação entre desmame e ocorrência de EP em eqüinos.…”

“…Em eqüinos enfermos, os sinais clínicos variam e podem incluir anorexia, letargia, depressão, perda de peso e emaciação em casos subagudos e crônicos, e diarréia aquosa profusa em casos agudos com curso de dois a 10 dias até o óbito, se não tratados (DUHAMEL & WHEELDON, 1982;WILLIAMS et al, 1996;FRANK et al, 1998, LAVOIE et al, 1998AL-GHAMDI, 2003;BIHR, 2003;WUERSCH et al, 2006). Sinais de febre (acima de 38.0 o C), desidratação leve à grave e anemia discreta foram vistos em vários casos (WILLIAMS et al, 1996;AL-GHAMDI, 2003;BIHR, 2003;WUERSCH et al, 2006).…”

“…Um projeto pioneiro referente ao estudo da ocorrência da EP em criatórios de eqüinos do Estado de Minas Gerais está sendo iniciado na Escola de Veterinária da Universidade Federal de Minas Gerais (UFMG), sob a coordenação do professor Roberto M. C. Guedes. O primeiro relato de EP em eqüinos foi feito por DUHAMEL & WHEELDON (1982), em um potro Árabe de seis meses de idade. Desde 1996, foram descritos vários relatos de casos individuais na América do Norte (WILLIAMS et al, 1996;FRANK et al, 1998;SCHUMACHER et al, 2000;BIHR, 2003;ATHERTON & McKENZIE III, 2006;DAUVILLIER et al, 2006;SAMPIERI et al, 2006) e surtos em três haras no Canadá (LAVOIE et al, 2000).…”