Intestinal absorption of mixed micellar phylloquinone (vitamin K1) is unreliable in infants with conjugated hyperbilirubinaemia: implications for oral prophylaxis of vitamin K deficiency bleeding

Pereira, Stephen P.

doi:10.1136/fn.88.2.f113

Cited by 49 publications

(46 citation statements)

References 51 publications

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“…There are only a few reports about direct measurements of serum concentrations of vitamin K after oral, intravenous or intramuscular single-dose administration [35][36][37][38][39]. As soon as sensitive analytical methods for vitamin K determination were introduced [28][29][32][33], information on the kinetics of phylloquinone became available.…”

Section: First Application Of the Hplc Methods In A Pharmacological Stmentioning

confidence: 99%

A Validated HPLC Method for the Determination of Vitamin K in Human Serum – First Application in a Pharmacological Study

Marinova¹,

Lütjohann

Westhofen³

et al. 2011

TOCCHEMJ

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Dietary phylloquinone (vitamin K1) is considered to be a major determinant of human vitamin K status. For this reason, measurements of plasma vitamin K concentrations provide a useful tool of vitamin K status in man. There is a growing interest in the role, biochemical function, and metabolism of vitamin K in vivo.A modified reversed phase-HPLC method with fluorescence detection after post-column zinc reduction in serum samples was validated for vitamin K analysis. Two human volunteers were investigated after p.o. and i.v. administration of 2 mg Konakion ® MM. Blood samples were collected periodically after administration and subjected to pharmacokinetic evaluation.High sensitivity, analytical recoveries, accuracy and calibration curves linearities could be reached. Our results showed an overall coefficient of variation of less than 10% for the intra-and interday reproducibility, while the recovery ranged from 91% to 114 %. The limit of detection and quantification were 0.015 ng mL -1 and 0.15 ng mL -1 , respectively. Long-term stability was verified over a period of six months. The accuracy was proven by good results from external quality assurance.The observed pharmacokinetic differences indicate significant intra-and inter-individual variance of vitamin K fate in the human body.This highly accurate, robust and reliable method is appropriate for the evaluation of vitamin K status in human serum. The ability to determine vitamin K has the potential to improve pharmacokinetic studies.

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Section: First Application Of the Hplc Methods In A Pharmacological Stmentioning

confidence: 99%

A Validated HPLC Method for the Determination of Vitamin K in Human Serum – First Application in a Pharmacological Study

Marinova¹,

Lütjohann

Westhofen³

et al. 2011

TOCCHEMJ

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“…In 1997, the CPS revised recommendations to indicate that a single intramuscular dose of 0.5 mg (birthweight 1500 g or less) or 1 mg (birthweight greater than 1500 g) should be given to all newborns within the first 6 h of life (12). While articles recommending continued use of oral vitamin K following birth continued to be published, the ideal dose, timing and formulation for oral prophylaxis were unclear and varied throughout (13)(14)(15)(16)(17).…”

mentioning

confidence: 99%

Canadian Paediatric Surveillance Program confirms low incidence of hemorrhagic disease of the newborn in Canada

McMillan

Grenier

Medaglia

2004

Paediatrics &Amp; Child Health

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“…About 30 per cent have minor bruising or other signs of coagulopathy (warning bleeds), preceding the serious haemorrhage. Infants at risk may have signs of predisposing cholestatic liver disease such as prolonged jaundice, pale stools, and hepatosplenomegaly 33 . The rate of VKDB in infants without prophylaxis has been reported as between five and 20 per 100,000 births.…”

Section: Vitamin K For Treatment Of Haemorrhagic Disease Of the Infantsmentioning

confidence: 99%

Vitamin K Prophylaxis in Infants

Lihanova¹

2018

Preprint

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A high incidence of Vitamin K deficiency bleeding (VKDB) in breastfed infants can cause life-long disability, especially if they occur in the brain. The way in which infants are administered vitamin K varies by country. Research on the optimal regimen of vitamin K prophylaxis administration has some limitations. There are no studies that directly compare the effect of different routes of administration of vitamin K to prevent bleeding. We summarized overview of Vitamin K policy for infants of VKDB in various countries.

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Intestinal absorption of mixed micellar phylloquinone (vitamin K1) is unreliable in infants with conjugated hyperbilirubinaemia: implications for oral prophylaxis of vitamin K deficiency bleeding

Cited by 49 publications

References 51 publications

A Validated HPLC Method for the Determination of Vitamin K in Human Serum – First Application in a Pharmacological Study

A Validated HPLC Method for the Determination of Vitamin K in Human Serum – First Application in a Pharmacological Study

Canadian Paediatric Surveillance Program confirms low incidence of hemorrhagic disease of the newborn in Canada

Vitamin K Prophylaxis in Infants

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