Intestinal Absorption of Calcium in Newborn Piglets

Lachenmaier-Currle, Ute; Harmeyer, J.

doi:10.1159/000242810

Cited by 19 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We conclude from this observation that in pigs potential renal 1,25-(OH) 2 D 3 production in either mother of fetus is not essential for maintenance of the Ca homeostasis of the pig fetus. In addition, both homozygote and heterozygote piglets showed normal intestinal absorption of Ca during the first two weeks of extra-uterine life [14]. Hypocalcemia and rickets developed in homozygote piglets not before an age of three to five weeks.…”

Section: Discussionmentioning

confidence: 94%

Placental transport of calcium and phoshorus in pigs

Lachenmaier-Currle¹,

Harmeyer²

1989

Jpme

View full text Add to dashboard Cite

The role of vitamin D in regulating placental transport of calcium and phosphate in pigs was studied using the "Hannover Pig Strain" which suffers from pseudo-vitamin D-deficiency rickets, type I. Sows and fetuses of normal phenotype (heterozygotes) and of homozygote phenotype which suffered from clinical symptoms of rickets were used. The homozygote animals are devoid of renal 25-cholecalciferol-1-hydroxylase. In the rachitic sows which normally depend on treatment with pharmacological doses of vitamin D3 at intervals of four to six weeks, vitamin D-treatment was discontinued two months before conception. Ca, P and 1.25-(OH)2D3 concentrations in plasma of sows and fetuses (Aa. umb., V. umb.) were measured in samples obtained at term during cesarian section. Mean concentrations of Ca and P in heterozygote sows at parturition were 2.34 mmol/l and 2.33 mmol/l, respectively, and were significantly higher than in homozygote sows, 1.58 mmol/l and 1.26 mmol/l, respectively. Ca concentrations in plasma of the umbilical vein of fetuses from both homozygote and heterozygote sows were normal, however, (3.23 mmol/l and 2.96 mmol/l, respectively) and statistically not different from each other. No significantly different P concentrations in arterial plasma of fetuses from heterozygote or homozygote sows were seen, either. The concentrations of Ca and P in the arterial umbilical plasma were significantly higher (p less than 0.001) than in venous plasma of both homozygote and heterozygote fetuses, indicating net placental transfer of these elements in both genotypes. The concentration of 1.25-(OH)2D3 in hypocalcemic sows at term (25.5 +/- 8.25 pg/ml) was significantly lower than that in the normocalcemic (heterozygote) sows (84.1 +/- 25.6 pg/ml). The 1.25-(OH)2D3 concentration in arterial plasma of fetuses from homozygote sows was only 46% that of fetuses from normocalcemic sows which showed transfer of calcitriol from mother to fetus. It is concluded from these studies that in pigs, renal production and physiological concentrations of 1.25-(OH)2D3 in either mother or fetus is not essential for the maintainance of the Ca and P homeostasis in the fetal-maternal system.

show abstract

Section: Discussionmentioning

confidence: 94%

Placental transport of calcium and phoshorus in pigs

Lachenmaier-Currle¹,

Harmeyer²

1989

Jpme

View full text Add to dashboard Cite

show abstract

“…Lordosis, kyphosis, hirsutism, and decreased feed intake have also been reported in swine suffering from rickets. 14,16 Chronic vitamin D deficiency promotes utilization of body calcium reserves in bone as a compensatory reaction to maintain normal serum calcium. Serum calcium concentrations are finely regulated by the animal and therefore strictly maintained within a narrow range.…”

mentioning

confidence: 99%

“…Apparently, vitamin D is not necessary for milk calcium absorption in suckling pigs, as receptor development has not yet occurred. 14,25 By 4 weeks of age, pigs rely on vitamin D for intestinal calcium absorption. 14 Approximately 90% of dietary vitamin D is absorbed in the proximal small intestine, and diarrheic animals can have lower vitamin D levels due to malabsorption.…”

mentioning

confidence: 99%

“…14,25 By 4 weeks of age, pigs rely on vitamin D for intestinal calcium absorption. 14 Approximately 90% of dietary vitamin D is absorbed in the proximal small intestine, and diarrheic animals can have lower vitamin D levels due to malabsorption. 19 Because weaned pigs have marginal serum 25(OH)D 3 levels at weaning, postweaning diarrhea may contribute to vitamin D deficiency and the development of metabolic issues.…”

mentioning

confidence: 99%

“…Lordosis, kyphosis, hirsutism, and decreased feed intake have also been reported in swine suffering from rickets. 14,16…”

mentioning

confidence: 99%

See 2 more Smart Citations

Rickets

et al. 2012

View full text Add to dashboard Cite

Rickets can be attributed to nutritional, genetic, hormonal, or toxic disturbances and is classified as a metabolic bone disease. Rickets is most often associated with inappropriate dietary levels of calcium, phosphorus, and/or vitamin D. During a 27-month period (January 2010 through March 2012), the Iowa State University Veterinary Diagnostic Laboratory investigated causes of sudden, unexpected death and lameness in growing pigs throughout the Midwestern United States. Clinical observations from 17 growing pig cases included weakness, lameness, reluctance to move, muscle fasciculations and/or tremors, tetany, and death. Ribs were weak, soft, and bent prior to breaking; rachitic lesions were apparent at costochondral junctions in multiple cases. Acute and/or chronic bone fractures were also noted in multiple bones. Failure of endochondral ossification, expanded physes, infractions, thin trabeculae, and increased osteoclasts were noted microscopically. Decreased bone ash and serum 25(OH)D(3), combined with clinical and microscopic evaluation, confirmed a diagnosis of vitamin D-dependent rickets in all cases. In 3 cases, disease was linked to a specific nutrient supplier that ultimately resulted in a voluntary feed recall; however, most cases in the current investigation were not associated with a particular feed company. The present report describes vitamin D-associated rickets and its importance as a potential cause of weakness, lameness, muscle fasciculations, recumbency or sudden unexpected death in swine, and describes appropriate samples and tests for disease diagnosis.

show abstract

Calcium and Zinc Retention From Protein Hydrolysate Formulas in Suckling Rhesus Monkeys

Rudloff¹

1992

Arch Pediatr Adolesc Med

View full text Add to dashboard Cite

Intestinal Absorption of Calcium in Newborn Piglets

Cited by 19 publications

References 9 publications

Placental transport of calcium and phoshorus in pigs

Placental transport of calcium and phoshorus in pigs

Rickets

Calcium and Zinc Retention From Protein Hydrolysate Formulas in Suckling Rhesus Monkeys

Contact Info

Product

Resources

About