Calcium and Zinc Retention From Protein Hydrolysate Formulas in Suckling Rhesus Monkeys

Rudloff, Silvia

doi:10.1001/archpedi.1992.02160170068017

Cited by 13 publications

(18 citation statements)

References 28 publications

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“…Also, monkey infants can be raised in primate nurseries where the amount and timing of iron in the diet can be precisely controlled through use of infant formulas. Infant monkeys have been used extensively as models for human infants to study absorption, growth and development with formulas of different nutritional content [11,13,35,51,58,41,42,43,33,40,54,57].…”

Section: Introductionmentioning

confidence: 99%

Behavioral consequences of developmental iron deficiency in infant rhesus monkeys

Golub

Hogrefe

Germann

et al. 2006

Neurotoxicology and Teratology

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Human studies have shown that iron deficiency and iron deficiency anemia in infants are associated with behavioral impairment, but the periods of brain development most susceptible to iron deficiency have not been established. In the present study, rhesus monkeys were deprived of iron by dietary iron restriction during prenatal (n = 14, 10 μg Fe/g diet) or early postnatal (n = 12, 1.5 mg Fe/L formula) brain development and compared to controls (n = 12, 100 μg Fe/g diet, 12 mg Fe/L formula) in behavioral evaluations conducted during the first four months of life in the nonhuman primate nursery. Iron deficiency anemia was detected in the pregnant dams in the third trimester and compromised iron status was seen in the prenatally iron-deprived infants at birth, but no iron deficiency was seen in either the prenatally or postnatally iron-deprived infants during the period of behavioral evaluation. Neither prenatal nor postnatal iron deprivation led to significant delays in growth, or gross or fine motor development. Prenatally deprived infants demonstrated a 20% reduced spontaneous activity level, lower inhibitory response to novel environments, and more changes from one behavior to another in weekly observation sessions. Postnatally deprived infants demonstrated poorer performance of an object concept task, and greater emotionality relative to controls. This study indicates that different syndromes of behavioral effects are associated with prenatal and postnatal iron deprivation in rhesus monkey infants and that these effects can occur in the absence of concurrent iron deficiency as reflected in hematological measures.

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Section: Introductionmentioning

confidence: 99%

Behavioral consequences of developmental iron deficiency in infant rhesus monkeys

Golub

Hogrefe

Germann

et al. 2006

Neurotoxicology and Teratology

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“…However, other in vitro studies 19,22,23 have reported greater calcium bioavailability from soy-based infant formulas than from milk-based infant formulas. Studies of rat pups 10 and weaned monkeys 11 have also reported lower bioavailability of calcium from soy-based infant formula than from milk-based infant formula. This reduced calcium bioavailability from soy-based infant formula has also been attributed to phytate 10 and to the types of peptides released during protein digestion 11 .…”

Section: Discussionmentioning

confidence: 99%

“…Studies of rat pups 10 and weaned monkeys 11 have also reported lower bioavailability of calcium from soy-based infant formula than from milk-based infant formula. This reduced calcium bioavailability from soy-based infant formula has also been attributed to phytate 10 and to the types of peptides released during protein digestion 11 . However, phytate appears to be less relevant, as new preparations of soy-based formulas have low phytate content 32 .…”

Section: Discussionmentioning

confidence: 99%

“…This position is based on several studies that analyzed the interactions among different nutrients and the bioavailability of iron, calcium and other minerals. Negative effects on iron and calcium absorption have been observed in studies conducted on rat pups 10 weaned monkeys 11 , infants 12,13 , and adults [13][14][15] . The negative effects were attributed to phytate 10 and to the types of peptides released during protein digestion 11,14,16 .…”

Section: Introductionmentioning

confidence: 99%

“…Negative effects on iron and calcium absorption have been observed in studies conducted on rat pups 10 weaned monkeys 11 , infants 12,13 , and adults [13][14][15] . The negative effects were attributed to phytate 10 and to the types of peptides released during protein digestion 11,14,16 . However, other studies have shown no negative effect on iron [17][18][19] or calcium 20,21 absorption when comparing soybased infant formula to milk-based infant formula.…”

Section: Introductionmentioning

confidence: 99%

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Intestinal absorption of iron and calcium from soy and cow's milk-based infant formulas in weanling rats pups

et al. 2017

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ObjectiveThis study aimed to compare the intestinal absorption of iron and calcium between soy-based and cow's milk-based infant formulas in weanling rats. MethodsTwenty male Wistar rats, twenty-one days old on the first day of weaning, were used in this experiment, divided in two Groups, one Group was fed soy protein-based infant formula the other, cow's milk protein-based infant formula. During the study period (ten consecutive days) the animals received food and water ad libitum. Hematocrit and hemoglobin were evaluated on the first, fifth, and tenth days by the Wintrobe and cyanomethemoglobin methods. Feces and urine were collected, beginning on the fifth day, for three consecutive days. On the tenth day, hepatic iron content was also analyzed. Hepatic iron as well as fecal and urinary iron and calcium analyses were performed using an atomic absorption spectrophotometer. At thirty-one days of age, the animals were anesthetized with ketamine and xylazine and sacrificed by exsanguination via the vena cava.

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Recent studies of iron deficiency during brain development in nonhuman primates

Golub

2010

BioFactors

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Recent studies of the effects of developmental iron deficiency and iron deficiency anemia in nonhuman primates have provided new insights into this widespread and well-recognized human nutritional deficiency. The rhesus monkey was the animal model in these experiments which used extensive hematological and behavioral evaluations in addition to noninvasive brain measures. Two important findings were (1) different behavioral consequences depending on the timing of iron deficiency relative to brain developmental stages, and (2) the potential for long lasting changes in brain iron regulatory systems. Further work in this model, including integration with studies in humans and in laboratory rodents, is ongoing.

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Calcium and Zinc Retention From Protein Hydrolysate Formulas in Suckling Rhesus Monkeys

Cited by 13 publications

References 28 publications

Behavioral consequences of developmental iron deficiency in infant rhesus monkeys

Behavioral consequences of developmental iron deficiency in infant rhesus monkeys

Intestinal absorption of iron and calcium from soy and cow's milk-based infant formulas in weanling rats pups

Recent studies of iron deficiency during brain development in nonhuman primates

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