Interventions for treating osteochondral defects of the talus in adults

Loveday, David; Clifton, R.; Robinson, A. H. N.

doi:10.1002/14651858.cd008104

Cited by 13 publications

(19 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3 Clinical outcomes of autologous chondrocytes implantation (ACI) and bone marrow derived cells transplantation (BMDCT). The trends were similar, with excellent results; nevertheless, BMDCT tended to slightly overcome ACI showed a tissue with biomechanical and structural properties close to normal hyaline articular cartilage [4,5,8,[22][23][24][25]. Despite the reported positive outcomes, no comparative study analysing the indications, advantages and drawbacks of ACI and BMDCT is currently available at follow up of 48 months.…”

Section: Discussionmentioning

confidence: 91%

See 1 more Smart Citation

Regenerative treatment in osteochondral lesions of the talus: autologous chondrocyte implantation versus one-step bone marrow derived cells transplantation

Buda

Vannini

Castagnini

et al. 2015

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 91%

“…According to literature, BMDCT and ACI [4,8,[22][23][24][25] seem to meet the criteria of promising regenerative techniques. Remarkable clinical and radiological results were reported for both the techniques.…”

Section: Discussionmentioning

confidence: 99%

Regenerative treatment in osteochondral lesions of the talus: autologous chondrocyte implantation versus one-step bone marrow derived cells transplantation

Buda

Vannini

Castagnini

et al. 2015

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

show abstract

“…The operative treatment paradigms for osteochondral lesions of the talus are controversial and a subject of frequent debate. A Cochrane review performed by Loveday et al concluded that there was a lack of evidence to determine which operative treatment strategy is most beneficial in treating osteochondral lesions of the talus in adults 5 . Treatment techniques include arthroscopic bone-marrow stimulation, tissue transplantation, and other cell-based techniques.…”

mentioning

confidence: 99%

Operative Treatment of Osteochondral Lesions of the Talus

Murawski

Kennedy

2013

Journal of Bone and Joint Surgery

233

202

View full text Add to dashboard Cite

➤ Osteochondral lesions of the talus are common injuries in recreational and professional athletes, with up to 50% of acute ankle sprains and fractures developing some form of chondral injury. Surgical treatment paradigms aim to restore the articular surface with a repair tissue similar to native cartilage and to provide long-term symptomatic relief.➤ Arthroscopic bone-marrow stimulation techniques, such as microfracture and drilling, perforate the subchondral plate with multiple openings to recruit mesenchymal stem cells from the underlying bone marrow to stimulate the differentiation of fibrocartilaginous repair tissue in the defect site. The ability of fibrocartilage to withstand mechanical loading and protect the subchondral bone over time is a concern.➤ Autologous osteochondral transplantation techniques replace the defect with a tubular unit of viable hyaline cartilage and bone from a donor site in the ipsilateral knee. In rare cases, a graft can also be harvested from the ipsilateral talus or contralateral knee. The limitations of donor site morbidity and the potential need for an osteotomy about the ankle should be considered. Some anterior or far posterior talar lesions can be accessed without arthrotomy or with a plafondplasty.➤ Osteochondral allograft transplantation allows an osteochondral lesion with a large surface area to be replaced with a single unit of viable articular cartilage and subchondral bone from a donor that is matched to size, shape, and surface curvature. The best available evidence suggests that this procedure should be limited to large-volume cystic lesions or salvage procedures.➤ Autologous chondrocyte implantation techniques require a two-stage procedure, the first for chondrocyte harvest and the second for implantation in a periosteum-covered or matrix-induced form after in vivo culture expansion. Theoretically, the transplantation of chondrocyte-like cells into the defect will result in hyaline-like repair tissue.

show abstract

“…In the literature, however, there is scarcity of randomized controlled studies to decide which treatment methods would be preferable for OCLs of the talus [23,37]. Therefore, no definitive conclusions can be made by the available data on the treatment of OCLs of the talus.…”

Section: Discussionmentioning

confidence: 99%