Interventions for the treatment of oral and oropharyngeal cancers: surgical treatment

Abstract

Analysis 1.1. Comparison 1 Elective neck dissection (ND) versus therapeutic (delayed) neck dissection, Outcome 1 Total mortality

Serum Levels of Interleukin-6 and Titers of Antibodies against Porphyromonas gingivalis Could Be Potential Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma

“…To lessen the damage, numerous therapeutic modalities such as radiotherapy, chemotherapy, and immunotherapy that could replace surgical treatment have been continuously developed, but the modalities have been successful for other types of cancer, such as leukemia, lymphoma, and breast cancer, rather than oral cancer [3,4,5,6,7,8,9]. These therapies cannot be applied for oral cancer as a primary solution and can only be used as an adjuvant therapy [10]. Due to this limitation, minimizing the need for surgery through the early detection of oral cancer is imperative to diminish undesirable outcomes.…”

Lifetime health care costs of oropharyngeal cancer for commercially insured patients in the United States

“…For head and neck cancers, nationwide studies that have used these primary data have not distinguished between HPV‐related malignancies (OPCs, including those of the tongue base and tonsils) and non‐HPV‐related malignancies (oral cavity cancers) 19,20 . Since the causes and clinical pictures of OPCs and oral cavity cancers are substantially different, management and prognosis for these two types of cancer are also different 21,22 . With most OPCs being diagnosed when more advanced than typical oral cavity cancers at diagnosis, it is likely that previous cost analysis reports, in which both cancers were combined, have underestimated the population‐attributable fraction of HPV for OPCs, resulting in an underestimation of the health care costs associated with OPC management 23 .…”

“…19,20 Since the causes and clinical pictures of OPCs and oral cavity cancers are substantially different, management and prognosis for these two types of cancer are also different. 21,22 With most OPCs being diagnosed when more advanced than typical oral cavity cancers at diagnosis, it is likely that previous cost analysis reports, in which both cancers were combined, have underestimated the population-attributable fraction of HPV for OPCs, resulting in an underestimation of the health care costs associated with OPC management. 23 This is due to the fact that, to date, no parameter can help identify HPV-induced head and neck cancers in diagnostic codes.…”

Oral squamous cell carcinoma resection and neck dissection mortality: a 10‐year national audit study

“…Neck dissection is a procedure performed by a head and neck surgeon to control regional metastatic disease. Due to the high risk of regional disease, even in a clinically node‐negative neck, a neck dissection is regularly indicated for OSCC, as recommended in a Cochrane review 6 …”

“…Due to the high risk of regional disease, even in a clinically nodenegative neck, a neck dissection is regularly indicated for OSCC, as recommended in a Cochrane review. 6 Surgical mortality of neck dissection is difficult to examine because there are many types of neck dissections and they are often performed with other major resections of the head and neck, each operation posing different risks. Post-operative mortality after neck dissection is dependent on many factors including extent of disease, type of neck dissection (radical versus selective) and patient factors such as history of radiotherapy and operator factors.…”