Interventions for preventing and treating trismus in patients with head and neck cancer

Carvalho, Alan PV; McNeely, Margaret L.; Vital, Flávia Mr

doi:10.1002/14651858.cd012316

Cited by 3 publications

(4 citation statements)

References 35 publications

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“…NPC01 is usually given after surgery, radiotherapy, and chemotherapy as an adjuvant therapy [3] to manage the adverse reactions of conventional treatments. HR-QOL measurement has become a crucial issue for HNC patients, and efforts are now directed towards reducing the impact of the disease and its treatment on patients' HR-QOL [22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Traditional Chinese medicine formula 01 for nasopharyngeal carcinoma (NPC01) for head & neck cancer and health-related quality of life: a retrospective study

Wang

et al. 2022

BMC Complement Med Ther

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Background The traditional Chinese medicine (TCM) formula 01 for nasopharyngeal carcinoma (NPC01) is used in the management of head and neck cancers (HNCs), but whether NPC01 has an impact on the HR-QOL of patients with HNCs is unknown. Methods This was a retrospective study of patients with HNCs who were treated between January 2019 and January 2020 at the Head & Neck Cancer Center of Tianjin Medical University Cancer Institute & Hospital. The patients were grouped according to whether they received NPC01 or not (controls). All patients routinely completed the EORTC QLQ-C30 and QLQ-H&N35 modules before and after 3 months of systemic treatment. Health economics were collected. Results The patients who received NPC01 were older than the controls (48.6 ± 11.4 vs. 43.4 ± 8.8 years, P = 0.004). All other characteristics were comparable between the two groups (all P > 0.05). In EORTC QLQ-C30, physical functioning (P = 0.03), fatigue (P = 0.04), pain (P = 0.02), appetite loss (P = 0.02), and constipation (P = 0.01) scores were improved more in the NPC01 group than in controls. In EORTC H&N35, the scores for pain (P = 0.02), swallowing (P = 0.01), and dry mouth (P = 0.02) were better in the NPC01 group than in controls. The NPC01 cost was 38.94 RMB/patient compared with 12.81 RMB/patient for regular follow-up, but considering insurance coverage, the financial burden was not higher. Conclusions The results suggest that NPC01 improves HNCs-related symptoms and HR-QOL.

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Section: Discussionmentioning

confidence: 99%

Traditional Chinese medicine formula 01 for nasopharyngeal carcinoma (NPC01) for head & neck cancer and health-related quality of life: a retrospective study

Wang

et al. 2022

BMC Complement Med Ther

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“…Early intervention is essential to prevent long-term disability [ 337 , 345 ]. The prevention of trismus, rather than its treatment, is the most important objective [ 337 , 346 , 347 ]. There should be regular post-RT reviews and measurement of IMO with dental or SLP professionals.…”

Section: Oropharyngeal Dysphagia Treatment In Head and Neck Cancermentioning

confidence: 99%

European white paper: oropharyngeal dysphagia in head and neck cancer

Baijens

Walshe

Aaltonen

et al. 2020

Eur Arch Otorhinolaryngol

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Purpose To develop a European White Paper document on oropharyngeal dysphagia (OD) in head and neck cancer (HNC). There are wide variations in the management of OD associated with HNC across Europe. Methods Experts in the management of specific aspects of OD in HNC across Europe were delegated by their professional medical and multidisciplinary societies to contribute to this document. Evidence is based on systematic reviews, consensus-based position statements, and expert opinion. Results Twenty-four sections on HNC-specific OD topics. Conclusion This European White Paper summarizes current best practice on management of OD in HNC, providing recommendations to support patients and health professionals. The body of literature and its level of evidence on diagnostics and treatment for OD in HNC remain poor. This is in the context of an expected increase in the prevalence of OD due to HNC in the near future. Contributing factors to increased prevalence include aging of our European population (including HNC patients) and an increase in human papillomavirus (HPV) related cancer, despite the introduction of HPV vaccination in various countries. We recommend timely implementation of OD screening in HNC patients while emphasizing the need for robust scientific research on the treatment of OD in HNC. Meanwhile, its management remains a challenge for European professional associations and policymakers.

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“… 8 , 9 Current treatments such as the use of wooden spatulas, Therabite ® (Atos Medical), Dynasplint ® (Dynasplint Systems Inc), and swallowing therapies, have shown only a modest effect once trismus is established. 10 , 11 , 12 , 13 , 14 However, Scherpenhuizen et al suggested that jaw exercises can improve mouth opening in patients with established radiotherapy-induced trismus. 12 In view of these conflicting opinions, there is consensus about the need for a rigorous, controlled study to provide clearer evidence of the value of exercise devices in patients who have trismus before radiotherapy or who have a high risk of developing it afterwards.…”

Section: Introductionmentioning

confidence: 99%

“… 12 In view of these conflicting opinions, there is consensus about the need for a rigorous, controlled study to provide clearer evidence of the value of exercise devices in patients who have trismus before radiotherapy or who have a high risk of developing it afterwards. 10 …”

Section: Introductionmentioning

confidence: 99%

Randomised feasibility study to compare the use of Therabite ® with wooden spatulas to relieve and prevent trismus in patients with cancer of the head and neck

Lee

Yeo

Rogers

et al. 2018

British Journal of Oral and Maxillofacial Surgery

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Our aim was to compare the efficacy of the Therabite® jaw motion rehabilitation system (Atos Medical) with that of wooden spatulas to relieve and prevent trismus in patients who have had radiotherapy for stage three and four oral and oropharyngeal cancer. Secondary aims were to assess the feasibility and the impact of exercise on health-related quality of life (QoL), and the use of health services after treatment. We designed a randomised, open-label, controlled, three-centre feasibility study to compare the effectiveness and cost of the Therabite® and wooden spatulas. We studied compliance with exercises and health-related QoL, assessed cost using three health economics measures, and conducted semistructured interviews with patients. Patients were randomised into two groups: the Therabite® group (n = 37) and the wooden spatula group (n = 34). All patients had some sense of jaw tightening before the study started. Mean mouth opening after six months increased in both groups, but the difference between the groups was not significant (p = 0.39). Completion rates for the three economic measures were good. There was no significant difference between the two groups in frequency of contact with care services or in QoL. Exercises during and after radiotherapy can ameliorate trismus in patients with stage three and four oral and oropharygeal cancers, but differences between groups in efficacy, compliance, QoL, or use of hospital or community health services, were not significant.

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Interventions for preventing and treating trismus in patients with head and neck cancer

Cited by 3 publications

References 35 publications

Traditional Chinese medicine formula 01 for nasopharyngeal carcinoma (NPC01) for head & neck cancer and health-related quality of life: a retrospective study

Traditional Chinese medicine formula 01 for nasopharyngeal carcinoma (NPC01) for head & neck cancer and health-related quality of life: a retrospective study

European white paper: oropharyngeal dysphagia in head and neck cancer

Randomised feasibility study to compare the use of Therabite ® with wooden spatulas to relieve and prevent trismus in patients with cancer of the head and neck

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