Interventions for head and neck cancer survivors: Systematic review

Margalit, Danielle N.; Salz, Talya; Venchiarutti, Rebecca L.; Milley, Kristi; McNamara, Mairead; Chima, Sophie; Wong, Jamieson; Druce, Paige; Nekhlyudov, Larissa

doi:10.1002/hed.27142

Cited by 8 publications

(10 citation statements)

References 56 publications

(268 reference statements)

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“…In recent decades, alterations in epidemiological patterns, the distinctive prognostic implications of HPV-associated cases, and advancements in treatment modalities have collectively contributed to a notable increase in the population of survivors of HNC ( 1 ). This article navigates through the multifaceted issues encountered by LC and OPC/HPC patients, emphasizing their profound impact on health related QOL.…”

Section: Discussionmentioning

confidence: 99%

“…The increasing population of head and neck cancer (HNC) survivors is partly due to improved treatment and changing epidemiology, with Human Papillomavirus (HPV)-associated cases having a more favorable prognosis than non-HPV related ones ( 1 ). This leads to long-lasting cancer-related effects that extend beyond the primary treatment phase ( 2 – 5 ), ultimately diminishing the health-related quality of life (QOL) compared to other types of cancer occurring in different anatomical sites.…”

Section: Introductionmentioning

confidence: 99%

“…This leads to long-lasting cancer-related effects that extend beyond the primary treatment phase ( 2 – 5 ), ultimately diminishing the health-related quality of life (QOL) compared to other types of cancer occurring in different anatomical sites. In addition to general complaints such as pain and fatigue, HNC patients often grapple with issues like oral dysfunction, voice, speech and swallowing problems with related social withdrawal and emotional distress ( 1 , 6 – 8 ).…”

Section: Introductionmentioning

confidence: 99%

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Enhancing quality of life in head and neck cancer patients: a comparative analysis of 3D exoscope-assisted surgery vs. traditional approaches

Marchi,

Bellini,

Ioppi

et al. 2024

Front. Surg.

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IntroductionThe increasing population of survivors of head and neck carcinomas is becoming more conspicuous. Consequently, the pivotal role of quality of life, particularly elucidated through the assessment of dysphagia and dysphonia, is progressively influencing the decision-making process. The current study aims to assess whether VITOM 3D could offer a comparable post-treatment quality of life to traditional approaches for patients with laryngeal cancer and oro-hypopharyngeal cancer.MethodsA case series of laryngeal cancer and oro-hypopharyngeal cancer patients treated either with an exoscopic-assisted surgical setup and with conventional treatments (transoral microsurgery and radio-chemotherapy) at the Otolaryngology Unit of IRCCS San Martino Hospital, Genoa, is presented. The post-treatment quality of life of the two cohorts were compared through the administration of the University of Washington Quality of Life Questionnaire, Voiceik Handicap Index-10, M.D. Anderson Dysphagia Inventory were administrated to both cohorts of patients.ResultsIn the laryngeal cancer group, a total of 79 patients were included. Of these, 50.1% underwent transoral exoscope-assisted surgery, while 49.9% underwent primary transoral microscopic-assisted surgical approach. No significant differences were observed in terms of the University of Washington Quality of Life Questionnaire and Voice Handicap Index-10 between the two subgroups. Conversely, in the oro-hypopharyngeal cancer group, 43 patients were included. Of these, 37.2% underwent primary transoral exoscope-assisted surgery, while 62.8% received (chemo)radiotherapy. No notable differences were reported in terms of the University of Washington Quality of Life Questionnaire and M.D. Anderson Dysphagia Inventory between the transoral exoscope-assisted surgery and (chemo)radiotherapy subgroups.ConclusionsAssessments of quality of life, conducted through the University of Washington Quality of Life Questionnaire questionnaire, dysphonia evaluations using the Voice Handicap Index-10, and dysphagia assessments employing the M.D. Anderson Dysphagia Inventory questionnaire, demonstrate analogous outcomes between conventional treatment modalities and transoral interventions utilizing the 3D exoscope.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enhancing quality of life in head and neck cancer patients: a comparative analysis of 3D exoscope-assisted surgery vs. traditional approaches

Marchi,

Bellini,

Ioppi

et al. 2024

Front. Surg.

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“…Consequently, the treatment of functional deficits and the improvement of QoL is an essential task in the context of interdisciplinary rehabilitation of PwHNC (1,2). The most commonly used supportive interventions in HNC survivors to date have focused on monitoring/treatment of physical effects (14). Physical exercise is a feasible, safe and promising approach to improve QoL in HNC survivors.…”

Section: Introductionmentioning

confidence: 99%

“…The most commonly used supportive interventions in HNC survivors to date have focused on monitoring/treatment of physical effects (14). Physical exercise is a feasible, safe and promising approach to improve QoL in HNC survivors.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of individualized home exercise programs for patients with head and neck cancer – study protocol and first results of a multicentre single-arm intervention trial (OSHO #94)

Felser,

Rogahn,

Glass

et al. 2024

Preprint

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Introduction Patients with head and neck cancer (PwHNC) benefit from targeted exercise interventions: symptom relief, compensation for dysfunction, improvement in quality of life (QoL). Data on acceptance physical interventions in PwHNC are rare. The ‘OSHO #94’ trial investigates the short- and medium-term effects of individualized home exercise in PwHNC on QoL, physical activity and functionality. The study includes a feasibility phase in order to evaluate the acceptance (Phase A), followed by a consecutive QoL endpoint Phase B. Here we present the study protocol as well as the feasibility results. Methods and analysis This prospective, multicentre, single-arm intervention study includes PwHNC ≥18 years of age in aftercare or palliative care with stable remission under immunotherapy. The study opened in January 01, 2021, with estimated completion by December 31, 2024. The PwHNC receive an individualized home exercise program consisting of mobilization, coordination, strengthening and stretching exercises. This should be carried out at least three times a week over 12 weeks for 15 to 30 minutes, supplemented by aerobic training two to three times a week for 30 minutes (intervention). Once weekly telephone calls with a physiotherapist are performed. Subsequently, there is a 12-week follow-up (FU) without exercise specifications/contact. Outcomes are measured before and after the intervention and following the FU. Primary outcome of the feasibility phase (Phase A, n = 25) was the determination of the dropout rate during the intervention with a termination cut off if more than 30% PwHNC withdrew premature. The primary outcome of phases A + B (N = 53) are the change in global QoL score from pre- to post-intervention (EORTC QLQ-C30). Secondary outcomes include clinical and patient-reported measures, training details as well as functional diagnostic data (e.g. level of physical activity, training frequency, flexibility, fall risk and aerobic performance). Results 25 PwHNC were enrolled onto the feasibility cohort. Only16% (4/25 patients) did not complete the study. Therefore, individualized home exercise programs in PwHNC seem feasible recruitment of PwHNC for phase B continued. The dropout rate was adjusted from 30% (N = 60) to 20% (N = 53, calculated sample size n = 42 PwHNC and 20% (n = 11) to dropout). Ethics and dissemination The study protocol was approved by the Ethics Committee of the University of Rostock, University of Halle-Wittenberg and University of Greifswald. The findings will be disseminated in peer-reviewed journals and academic conferences. Trial registration German Registry of Clinical Trials DRKS00023883.

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Interventions for head and neck cancer survivors: Systematic review

et al. 2022

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Background Interventions for head/neck cancer (HNC) survivors may not address their cancer‐related and general health needs. Methods Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) guided this systematic review of studies from 2000 to 2021 of interventions targeting cancer survivors treated with curative‐intent, using MEDLINE, Embase, Emcare, and PsycINFO. Interventions were categorized into domains of the Quality of Cancer Survivorship Care Framework to characterize the scope and quality of interventions. Results We identified 28 studies for inclusion: 13 randomized and 15 non‐randomized. Most targeted surveillance/management of physical effects (n = 24) including 13 that also targeted psychosocial effects. Four studies addressed prevention/surveillance for recurrence/new cancers, one addressed health promotion/disease prevention, and one addressed chronic medical conditions. Most studies (n = 27) had medium‐high risk of bias. Conclusions There are few high‐quality studies addressing HNC survivorship. Future rigorously designed studies should address broader areas of care, including chronic disease management and health promotion/disease prevention.

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Interventions for head and neck cancer survivors: Systematic review

Cited by 8 publications

References 56 publications

Enhancing quality of life in head and neck cancer patients: a comparative analysis of 3D exoscope-assisted surgery vs. traditional approaches

Enhancing quality of life in head and neck cancer patients: a comparative analysis of 3D exoscope-assisted surgery vs. traditional approaches

Feasibility of individualized home exercise programs for patients with head and neck cancer – study protocol and first results of a multicentre single-arm intervention trial (OSHO #94)

Interventions for head and neck cancer survivors: Systematic review

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