Interventions for hand eczema

Christoffers, Wietske Andrea; Coenraads, Pieter‐Jan; Svensson, Åke; Diepgen, Thomas L.; Dickinson-Blok, J. L.; Xia, Jun; Williams, Hywel C

doi:10.1002/14651858.cd004055.pub2

Cited by 43 publications

(131 citation statements)

References 122 publications

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“…Studies on treatment effectiveness are mainly based on physician‐reported outcomes. Fewer studies have actually evaluated treatment benefit in terms of patient‐reported outcomes . However, chronic hand eczema can have a remarkable impact on quality of life …”

Section: Introductionmentioning

confidence: 99%

“…Fewer studies have actually evaluated treatment benefit in terms of patientreported outcomes. 4,5 However, chronic hand eczema can have a remarkable impact on quality of life. 2,6 To evaluate the impact of disease and treatment on physical, psychological, and social functioning, the Quality of Life in Hand Eczema Questionnaire (QOLHEQ) was recently developed.…”

Section: Introductionmentioning

confidence: 99%

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Quality of life, treatment satisfaction, and adherence to treatment in patients with vesicular hand eczema: A cross‐sectional study

et al. 2020

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Background Recurrent vesicular hand eczema frequently has a chronic course and needs long‐term treatment. Objectives To evaluate health‐related quality of life (HRQoL), treatment satisfaction, and adherence in patients with vesicular hand eczema. Methods Patients using one main treatment for at least three months were included. Data on HRQoL (Quality of Life in Hand Eczema Questionnaire [QOLHEQ]), treatment satisfaction (Treatment Satisfaction Questionnaire for Medication, version II), and treatment adherence (4‐item Morisky Medication Adherence Scale) were collected. Univariate and multivariate regression analysis were used to predict variables associated with HRQoL. Results HRQoL was moderately impaired, with the highest impact in the QOLHEQ subdomain symptoms. Female sex, more severe hand eczema, and lower treatment satisfaction were associated with more impairment in HRQoL. Patients with severe/very severe hand eczema had significant lower “global satisfaction” scores compared with the other severity groups. The “global satisfaction” and treatment adherence in patients using systemic treatment were significantly higher compared with those with only topical treatment. Conclusions In patients with vesicular hand eczema disease severity affects both HRQoL and treatment satisfaction. Systemic treatment of severe hand eczema could improve the severity and as a result also HRQoL, treatment satisfaction, and medication adherence.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quality of life, treatment satisfaction, and adherence to treatment in patients with vesicular hand eczema: A cross‐sectional study

et al. 2020

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“…4 Clobetasol propionate 0.05% foam and mometasone furoate cream probably improve control of symptoms, but the evidence was rated as moderate and low certainty, respectively. Considering their long history of use, it seems odd that the recent Cochrane review identified only nine studies that evaluated topical corticosteroids as the main intervention.…”

Section: Topical Glucocorticosteroidsmentioning

confidence: 99%

“…4 Due to the side effects of systemic psoralen application, especially nausea and the need for full body UV protection and specific sunglasses, some clinics have abandoned systemic PUVA and use bath or cream PUVA treatment in hand eczema instead. 4 Due to the side effects of systemic psoralen application, especially nausea and the need for full body UV protection and specific sunglasses, some clinics have abandoned systemic PUVA and use bath or cream PUVA treatment in hand eczema instead.…”

Section: Uv-phototherapymentioning

confidence: 99%

“…This review takes into account these aspects with a view on the guidelines for the management of hand eczema that have been developed by various groups over the years (Table 1) and the recent Cochrane review on treatments for hand eczema. 4 The latter clearly stated the current deficits of our knowledge on the treatment of hand eczema 4 : the quality of studies was frequently poor, and the duration of treatment was short, generally only up to 4 months, which is inconsistent with the need for a long-term management in chronic hand eczema defined as 'an eczematous process that lasts for more than three months or relapses twice or more often per year'. 5 Most of the guidelines (Table 1) take a similar approach to the hierarchy of treatments with some differences especially regarding the availability or reimbursement conditions of specific drugs.…”

Section: Introductionmentioning

confidence: 99%

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Hand eczema: treatment

Elsner

Agner

2019

Acad Dermatol Venereol

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Hand eczema is a highly prevalent, multietiological disease with a wide spectrum of severity and chronicity. The treatment of hand eczema, especially in severe and chronic cases, is a challenge to the dermatologist requiring not only diagnostic and therapeutic, but also excellent patient communication skills. This review discusses the spectrum of therapeutic options for hand eczema, the evidence for their efficacy and safety, and proposes a stepwise approach of intensity of treatment depending on disease severity and chronicity. In the near future, hand eczema patients may benefit from new therapeutic principles such as biologics for the treatment of atopic eczema and topical Janus Kinase inhibitors.

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