Interventions for basal cell carcinoma of the skin

Abstract

Interventions for basal cell carcinoma of the skin (Review)

Tumor thickness and adnexal extension of superficial basal cell carcinoma (sBCC) as determinants of treatment failure for methylaminolevulinate (MAL)-photodynamic therapy (PDT), imiquimod, and 5-fluorouracil (FU)

“…In addition, PDT, imiquimod, and 5-FU have the benefit of a better cosmetic outcome compared with surgical excision. 4 However, recurrence rates of noninvasive treatments are higher compared with surgery and range from 13% to 27% at 1-year posttreatment. 5,6 Little is known about histologic characteristics of sBCC that may influence treatment response of noninvasive therapies.…”

Mohs micrographic surgery for periocular skin tumours in Ireland

“…A recent Cochrane review concluded that excision is superior to the other treatment modalities [9]. To date there is just one randomised controlled trial (RCT) comparing MMS to standard surgical excision and this showed that MMS is better for treating recurrent BCCs but only trended toward superiority for primary BCCs [10].…”

“…The Cochrane reviews [9,12] acknowledge that there is a paucity of RCT evidence; however, there have been several sizeable prospective case series and much literature published in Australia where BCC is a major public health concern [13,14,15]. Large non-randomised and retrospective studies suggest that standard excision has recurrence rates of 3-10 % for primary tumours and [17 % for recurrent tumours, [8,16,17] whereas, MMS yields recurrence rates of 1 % for primary tumours [18] and 5-7 % for recurrent tumours [19,20,21].…”

Treatment of Non-Melanomatous Skin Cancer with Radiotherapy

“…Radiotherapy is generally regarded as the best option following surgery [5]. The superiority of RT over some other treatment modalities has been illustrated in data such as a randomized controlled trial comparing RT with cryotherapy.…”