Treatment of Non-Melanomatous Skin Cancer with Radiotherapy

Haseltine, Justin M.; Wernicke, A. Gabriella; Formenti, Silvia C.; Parashar, Bhupesh

doi:10.1007/s13671-015-0117-2

Cited by 3 publications

(3 citation statements)

References 69 publications

(84 reference statements)

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“…Non-melanomatous skin cancer (NMSC) is the single most common cancer in the US with an incidence of 2-3 million cases per year [ 1 ]. NMSC is comprised of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), and also includes Merkel cell carcinoma (MCC) and adnexal tumors [ 2 ]. While surgical excision is the standard of care, radiotherapy (RT) is an excellent alternative with high cure rates and good cosmetic outcome [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ].…”

Section: Purposementioning

confidence: 99%

Clinical comparison of brachytherapy versus hypofractionated external beam radiation versus standard fractionation external beam radiation for non-melanomatous skin cancers

Haseltine

Parker

Wernicke

et al. 2016

jcb

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PurposeNon-melanomatous skin cancer (NMSC) is the single most common cancer in the US. Radiation therapy is an excellent treatment alternative to surgery. High-dose-rate (HDR) brachytherapy and external beam radiotherapy (EBRT) are commonly used radiation treatment modalities but little data is published comparing these modalities. We present our institution's experience and outcomes with these therapeutic options.Material and methodsFrom June 2005 to March 2013, 61 patients were treated with HDR brachytherapy (n = 9), hypofractionated EBRT (n = 30), or standard fractionation EBRT (n = 22) for NMSC. The primary outcome measure was local control at most remote follow-up and secondary outcome measures were overall survival, cosmetic outcome, and toxicity. Univariate analysis was performed to compare outcomes between treatment modalities. Kaplan-Meier analysis and log-rank test were used to compare overall survival.ResultsMedian follow-up was 30 months. The most common histologies were BCC (47%) and SCC (44%); mean patient age was 83.3 years. Local control was 81% and 2-year actuarial overall survival was 89%. There was no statistical difference in local control or overall survival between treatment modalities. There was no statistical difference in cosmetic outcome or toxicity between treatment modalities, although five of six “poor” cosmetic outcomes and the only grade 3 toxic events were found in the standard fractionation EBRT group.ConclusionsAll modalities investigated represent effective treatments for NMSC and have good cosmetic outcomes and acceptable toxicity profiles. The finding of higher grade toxicity and a greater portion of patients experiencing toxicity among standard fractionation therapy is counter to expectations. There was no statistical significance to the finding and it is not likely to be meaningful.

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Section: Purposementioning

confidence: 99%

Clinical comparison of brachytherapy versus hypofractionated external beam radiation versus standard fractionation external beam radiation for non-melanomatous skin cancers

Haseltine

Parker

Wernicke

et al. 2016

jcb

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“…An alternative is intensity modulated proton therapy, which may protect normal structures better and reduce the integral dose due to a very low exit dose [15].…”

Section: Advanced Lesions-locally Advanced or Neck Involvementmentioning

confidence: 99%

“…Its major advantage is the Bragg peak, which delivers a high dose to the target with a very rapid falloff, and therefore a very low exit dose. Its main disadvantages are the cost and scarce availability, as well as technical challenges regarding the entrance dose [15,16].…”

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confidence: 99%

The Role of Radiation Therapy in the Treatment of Non-Melanoma Skin Cancer

Yosefof

Kurman

Yaniv

2023

Cancers

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Non-melanoma skin cancer (NMSC) is the most common malignancy in the United States. While surgery is considered as the main treatment modality for both cutaneous basal cell carcinoma (cBCC) and cutaneous squamous cell carcinoma (cSCC), radiotherapy plays an important role in the treatment of NMSC, both in the adjuvant setting for cases considered high-risk for recurrence, and in the definitive setting, when surgery is not feasible or desired by the patient. The last years have seen the emergence of immunotherapy treatment for cases of advanced cSCC in the palliative, and possibly neoadjuvant settings, making the treatment paradigm more complex. In this review, we attempt to describe the different radiation modalities available for the treatment of NMSC, the indications for adjuvant post-operative treatment with radiotherapy for cSCC, the role of radiotherapy in elective neck treatment, and the efficacy, safety, and toxicity profile of this treatment in these different settings. Furthermore, we aim to describe the efficacy of radiotherapy combined with immunotherapy as a promising horizon for treating advanced cSCC. We also aim to describe the ongoing clinical studies that attempt to examine future directions for the role of radiation treatment in NMSC.

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Innovative 3D printing and molding process for secondary-skin-collimator fabrication

Sohn,

Kim,

Stolen

et al. 2024

Biomed. Phys. Eng. Express

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Purpose: Secondary skin collimation (SSC) is essential for shielding normal tissues near tumors during electron and orthovoltage radiation treatments. Traditional SSC fabrication methods, such as crafting in-house lead sheets, are labor-intensive and produce SSCs with low geometric accuracy. This study introduces a workflow that integrated 3D scanning and 3D printing technologies with an in-house mold process, enabling the production of patient-specific SSCs within six hours.Methods: An anthropomorphic head phantom was scanned with a handheld 3D scanner. The resulting scan data was imported into 3D modeling software for design. The completed model was exported to a 3D printer as a printable file. Subsequently, molten Cerrobend was poured into the mold and allowed to set, completing the SSC production. Geometric accuracy was assessed using CT images, and the shielding effectiveness was evaluated through film dosimetry.Results: The 3D printed mold achieved submillimeter accuracy (0.5 mm) and exhibited high conformity to the phantom surface. It successfully endured the weight and heat of the Cerrobend during pouring and curing. Dosimetric analysis conducted with radiochromic film demonstrated good agreement between the measured and expected attenuation values of the SSC slab, within ±3%.Conclusions: This study presents a proof of concept for novel mold room workflows that produce patient-specific SSCs within six hours, a significant improvement over the traditional SSC fabrication process, which takes 2–3 days. The submillimeter accuracy and versatility of 3D scanning and printing technologies afford greater design freedom and enhanced delivery accuracy for cases involving irregular geometries.

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Treatment of Non-Melanomatous Skin Cancer with Radiotherapy

Cited by 3 publications

References 69 publications

Clinical comparison of brachytherapy versus hypofractionated external beam radiation versus standard fractionation external beam radiation for non-melanomatous skin cancers

Clinical comparison of brachytherapy versus hypofractionated external beam radiation versus standard fractionation external beam radiation for non-melanomatous skin cancers

The Role of Radiation Therapy in the Treatment of Non-Melanoma Skin Cancer

Innovative 3D printing and molding process for secondary-skin-collimator fabrication

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