Interventions for atrophic rhinitis

Mishra, Anupam; Kawatra, Rahul; Gola, Manoj

doi:10.1002/14651858.cd008280.pub2

Cited by 27 publications

(25 citation statements)

References 25 publications

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“…This can be achieved by surgically closing the nasal cavities (modified Young procedure) or implanting prostheses submucosally to decrease nasal cavity size. 157,161 However, a Cochrane review concluded there are no adequate randomized controlled studies of sufficient duration that compare these treatment options. 161 NAR with eosinophilia syndrome NARES was first was used in 1981 as a term to describe a case series of patients who were nonasthmatic that reported perennial, intermittent symptoms of profuse clear rhinorrhea and paroxysms of sneezing as well as nasal or ocular pruritus, lacrimation, and nasal congestion without complete obstruction.…”

Section: Atrophic Rhinitismentioning

confidence: 99%

Rhinitis 2020: A practice parameter update

Parameters

Contributors

2020

Journal of Allergy and Clinical Immunology

211

189

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Section: Atrophic Rhinitismentioning

confidence: 99%

Rhinitis 2020: A practice parameter update

Parameters

Contributors

2020

Journal of Allergy and Clinical Immunology

211

189

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“…The management of ENS is challenging and the evidence base for most treatment modalities remains low . Recommended conservative management does not differ significantly from atrophic rhinitis, which includes nasal lavage, lubricant drops, and topical corticosteroids .…”

Section: Introductionmentioning

confidence: 99%

The clinical efficacy of surgical interventions for empty nose syndrome: A systematic review

Leong

2015

The Laryngoscope

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“…Патоморфологические изменения включают уменьшение капиллярной сети, гипертрофию интимы сосудов слизистой оболочки, увеличение числа и толщины эластических волокон с разрастанием соединительной ткани, исчезновением извилистости внутренней эластической мембраны, увеличение числа мышечных волокон кровеносных сосудов. Часто в стенках собственного слоя слизистой оболочки развиваются патологические изменения по типу облитерирующего эндартериита [2,5]. Все это приводит к уменьшению их просвета и ухудшению эластических свойств.…”

Section: ;19;4(107)unclassified

Evaluation of efficacy of the Olyfrin spray in treatment of patients with atrophic rhinitis using the Russian-language version of SNOT-25 questionnaire with Houser's modifications

Chuchueva¹,

Савлевич²,

Козлов³

et al. 2020

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Atrophic rhinitis at the same time significantly reduces the quality of life of patients suffering from it and is a refractory pathology. The current therapy for the disease includes conservative and sometimes surgical treatment. Nevertheless, the problem of effective therapeutic method remains to be relevant and requires the search for new medicines. Also, there is no tool for assessing the severity of symptoms and quality of life in patients with atrophic rhinitis. The internationally accepted SNOT-25 (Sino-Nasal Outcome Test-25) questionnaire with Houser’s modifications is used to assess the severity of symptoms of patients with empty nose syndrome and could be successfully applied for examination of patients with atrophic rhinitis. Research objectives. This research is aimed to evaluate the efficacy of the Russian nasal spray Olyfrin in the treatment of atrophic rhinitis. And also, to assess the possibility of using the SNOT 25 questionnaire with Houser’s modifications to determine symptom severity of atrophic rhinitis. Materials and Methods. At the first stage - validation of the SNOT-25 questionnaire modified by Houser - 64 patients were included in the study: 29 patients with atrophic rhinitis, 35 with other forms of chronic rhinitis. All patients filled in a prepared and adapted Russian-language version of the questionnaire. At the second stage - determination of the effectiveness of the spray Olyfrin in the treatment of atrophic rhinitis - the study included 29 patients with atrophic rhinitis. Olyfrin was used in 1 dose 3 times a day for 14 days. The dynamics of the severity of symptoms was assessed on the 7th and 14th days using the SNOT-25 questionnaire with Houser’s modifications. Analysis of the total number of points according to SNOT 25 with Houser’s modifications, along with the number of points scored for each of the questions, revealed a significant difference between the group of patients with atrophic rhinitis and the group of patients with other forms of chronic rhinitis (p <0.05). When studying the efficacy of the spray Olyfrin, statistically significant differences were found in the sum of points on the questionnaire before treatment and on the 7th day after treatment (p = 0.005), as well as before treatment and on the 14th day after treatment (p <0.001). A significant difference (p <0.05) was also obtained depending on the day of treatment with a decrease in the number of points of the severity of dryness in the nose (3.75 ± 1.55 vs 1.76 ± 1.43), sensation of excessive openness of the nose (0, 62 ± 0.26 vs 0.41 ± 0.14) and the formation of crusts in the nasal cavity (3.45 ± 1.37 vs 1.76 ± 0.87) already on the 7th day of treatment, and for all these symptoms with an additional decrease in the severity of the feeling of suffocation (1.14 ± 0.29 vs 0.28 ± 0.1) and difficulty in nasal breathing (1.62 ± 0.33 vs 0.45 ± 0.12) on the 14th day of treatment. Conclusions. According to our study, Olyfrin nasal spray is advisable to use when prescribing empirical therapy for patients with atrophic rhinitis. And to assess the quality of life and the dynamics of treatment of patients with atrophic rhinitis, the Russian-language version of the SNOT-25 questionnaire with Houser’s modifications can be successfully used.

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Interventions for atrophic rhinitis

Cited by 27 publications

References 25 publications

Rhinitis 2020: A practice parameter update

Rhinitis 2020: A practice parameter update

The clinical efficacy of surgical interventions for empty nose syndrome: A systematic review

Evaluation of efficacy of the Olyfrin spray in treatment of patients with atrophic rhinitis using the Russian-language version of SNOT-25 questionnaire with Houser's modifications

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