“…A total of 37 trials were included ( Figure 1 ) [ 2 ], of which 49 were experimental interventions and 37 were comparison interventions. Of the 37 trials, 29 evaluated one experimental intervention [ 7 , 8 , 14 , 28 - 53 ], 4 trials evaluated two experimental interventions [ 54 - 57 ], and 4 trials evaluated three experimental interventions [ 58 - 61 ]. Trials were published from 1981 and 2016 and conducted in patients with cardiovascular disease or heart failure (n=13) [ 7 , 8 , 29 , 31 , 36 - 40 , 42 , 56 , 57 , 62 ], hypertension (n=11) [ 14 , 32 - 34 , 43 , 44 , 54 - 56 , 59 , 60 ], diabetes (n=10) [ 14 , 28 , 30 , 35 , 45 - 50 , 56 , 61 ], kidney disease (n=3) [ 51 , 52 , 58 ], and obesity (n=3) [ 32 , 53 , 57 ].…”