Intervention effects of lotus leaf flavonoids on gastric mucosal lesions in mice infected with Helicobacter pylori

Abstract

Lotus leaf flavonoids can inhibit gastric mucosal lesions caused by Helicobacter pylori in mice.

Chalcones and Gastrointestinal Cancers: Experimental Evidence

“…At a dose of 100 mg/kg/day for 2 weeks, there was a significant reduction in gastric lesions compared to both the control and ranitidine groups. The authors also noted significant decreases in the inflammatory cytokines IL-6, IL-12, TNF-α and IFN-γ and changes in the levels of substance P, endothelin-1, vasoactive intestinal polypeptide (VIP) and somatostatin in the murine serum after the administration of the LLF [ 249 ].…”

Phenolic-rich extract of Nopalea cochenillifera attenuates gastric lesions induced in experimental models through inhibiting oxidative stress, modulating inflammatory markers and a cytoprotective effect

“…In this study, it was observed that the pre-treatment with this flavonoid showed gastroprotective activity, significantly improving parameters of oxidative stress and inflammation in gastric tissue. Meanwhile, in the present work, rutin, a polyphenolic compound found in N. cochenillifera hydroethanolic extract, was reported by Yi et al 68 and Serafim et al 69 to have gastroprotective properties and to strengthen the mucus barrier, and act as an antioxidant. In the study carried out by Campos-Vidal et al 70 other medicinal plants were reported with gastroprotective effects, then was observed that Byrsonima sericea DC ethanol extract was effective in reducing the ulcers in ethanol-induced model and moreover kaempferol-3- O -rutinoside and quercetin-3- O -rutinoside were identified in this plant, which may be correlated with this pharmacological effect.…”

Mesenchymal Stem Cells Accelerate Recovery of Acetic Acid-Induced Chronic Gastric Ulcer by Regulating Ekt/Akt/TRIM29 Axis

“…Hericium erinaceus mycelia could regulate epidermal differentiation by decreasing the expression of Krt16 and Krt6b, thus alleviating ethanol-induced chronic gastric injury in mice [ 38 ]. Another study revealed that lotus leaf flavonoids can negatively regulate the expression of Krt16 and Krt6b mRNA in gastric tissues of mice with Helicobacter pylori ( H. pylori )-induced gastric lesions [ 39 ]. KrtA and KrtB are overexpressed in skin lesions and epithelial repair and are significantly downregulated in the margin of unhealed venous ulcers [ 40 ].…”