Interval Vibration Reduces Orthodontic Pain <i>Via</i> a Mechanism Involving Down-regulation of TRPV1 and CGRP

Thammanichanon, Peungchaleoy; Kaewpitak, Aunwaya; Binlateh, Thunwa; Leethanakul, Chidchanok

doi:10.21873/invivo.12052

Cited by 12 publications

(13 citation statements)

References 26 publications

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“…Experiments showed that after 1 day of tooth movement, the expression of TRPV1 also reached a peak, consistent with the peak of pain 61 . TRPV1 promotes TN to secrete neuropeptides such as SP and CGRP after activated 45 and induces neurogenic pain. Interestingly applying orthodontic force and then giving vibration can relieve orthodontic pain, which may be related to TRPV1.…”

Section: Mechanismmentioning

confidence: 53%

“…CGRP is mainly released at the end of axons neuron in vesicles through exocytosis 44 . Tooth movement causes the nociceptor fibres in the periodontal tissue to release CGRP into the periodontal tissue, which transmits the signal to the TG to increase the excitability of the TN 22,45 . In addition, CGRP also has an effect on SGCs, upregulating the expression of nitric oxide in the p38 signalling pathway, accelerating the release of signal molecules that stimulate neurons and promoting the occurrence of pain 46 …”

Section: Mechanismmentioning

confidence: 99%

“…Interestingly applying orthodontic force and then giving vibration can relieve orthodontic pain, which may be related to TRPV1. That is, vibration can reduce the area of the PDL under pressure and alleviate the ischaemic and low pH condition 45 . This also may be related to the inverse transport of axons in primary sensory neurons that are stimulated by inhibitory neurons 45 …”

Section: Mechanismmentioning

confidence: 99%

“…That is, vibration can reduce the area of the PDL under pressure and alleviate the ischaemic and low pH condition 45 . This also may be related to the inverse transport of axons in primary sensory neurons that are stimulated by inhibitory neurons 45 …”

Section: Mechanismmentioning

confidence: 99%

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Molecular mechanism in trigeminal nerve and treatment methods related to orthodontic pain

Tang

Long

Gao

et al. 2021

J of Oral Rehabilitation

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Background Orthodontic treatment is the main treatment approach for malocclusion. Orthodontic pain is an inevitable undesirable adverse reaction during orthodontic treatment. It is reported orthodontic pain has become one of the most common reason that patients withdraw from orthodontic treatment. Therefore, understanding the underlying mechanism and finding treatment of orthodontic pain are in urgent need. Aims This article aims to sort out the mechanisms and treatments of orthodontic pain, hoping to provide some ideas for future orthodontic pain relief. Materials Tooth movement will cause local inflammation. Certain inflammatory factors and cytokines stimulating the trigeminal nerve and further generating pain perception, as well as drugs and molecular targeted therapy blocking nerve conduction pathways, will be reviewed in this article. Method We review and summaries current studies related to molecular mechanisms and treatment approaches in orthodontic pain control. Results Orthodontics pain related influencing factors and molecular mechanisms has been introduced. Commonly used clinical methods in orthodontic pain control has been evaluated. Discussion With the clarification of more molecular mechanisms, the direction of orthodontic pain treatment will shift to targeted drugs.

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Section: Mechanismmentioning

confidence: 53%

Section: Mechanismmentioning

confidence: 99%

Section: Mechanismmentioning

confidence: 99%

Section: Mechanismmentioning

confidence: 99%

See 2 more Smart Citations

Molecular mechanism in trigeminal nerve and treatment methods related to orthodontic pain

Tang

Long

Gao

et al. 2021

J of Oral Rehabilitation

View full text Add to dashboard Cite

show abstract

“…However, there is a paucity of information to explain how vibration works at a cellular level. Others have shown that vibration reduces calcitonin-gene related peptides (CGRP) [ 44 ]. CGRP are involved in proinflammatory responses noted in migraine pathophysiology [ 45 ] and whose reduction has been shown to alleviate migraine pain in animal models [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Vibration, a treatment for migraine, linked to calpain driven changes in actin cytoskeleton

et al. 2022

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Understanding how a human cell reacts to external physical stimuli is essential to understanding why vibration can elicit localized pain reduction. Stimulation of epithelial cells with external vibration forces has been shown to change cell shape, particularly in regards to structures involved in non-muscle cell motility. We hypothesized that epithelial cells respond to vibration transduction by altering proteins involved in remodeling cytoskeleton. Epithelial cells were exposed to vibration and assessed by microscopy, cytoskeletal staining, immunoblotting and quantitative RT-PCR. Here, we report that epithelial cell lines exposed to 15 minutes of vibration retract filopodia and concentrate actin at the periphery of the cell. In particular, we show an increased expression of the calcium-dependent, cysteine protease, calpain. The discovery that cell transitions are induced by limited exposure to natural forces, such as vibration, provides a foundation to explain how vibrational treatment helps migraine patients.

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Potential Role of Focal Microvibration (Equistasi®) in the Management of Chronic Pain: A Pilot Study

Buonanno,

Iacovazzo,

Marra

et al. 2023

Pain Ther

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Interval Vibration Reduces Orthodontic Pain Via a Mechanism Involving Down-regulation of TRPV1 and CGRP

Cited by 12 publications

References 26 publications

Molecular mechanism in trigeminal nerve and treatment methods related to orthodontic pain

Molecular mechanism in trigeminal nerve and treatment methods related to orthodontic pain

Vibration, a treatment for migraine, linked to calpain driven changes in actin cytoskeleton

Potential Role of Focal Microvibration (Equistasi®) in the Management of Chronic Pain: A Pilot Study

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