Interstitial radiation therapy for early-stage nasal vestibule cancer: A continuing quest for optimal tumor control and cosmesis

Cutaneous squamous cell carcinoma of the columella with an unusual revelation: a rare case report and a literature review of its staging and management challenges

“…According to many authors, this staging system predicts prognosis of nasal vestibule tumors more accurately [8][9][10][11]. It is relatively simple and includes only three stages (T1: involving only vestibule skin; T2: invading subcutaneous tissue and cartilage; T3: invading bone).…”

IMRT for Nasal Tumors – Local Control and Cosmetic Outcome

“…In historic series on cohorts treating nasal vestibule tumors with conventional RT or brachytherapy, local control and overall survival rates range from 67% to 92% and 50% to 90%, respectively [2,4,6,14]. The largest series of the DAHANCA study group including 174 patients with nasal vestibule cancer reports a local control rate and an overall survival rate of 67% and 50% at 5 years, respectively [14] (Table 3).…”

“…They scored cosmetic results using a 3 point scale. 65% showed good or excellent objective results judged by an external panel [6]. We used a five point scale in order to further differentiate outcome.…”

“…Larger studies including nasal tumors executively are mostly not applying chemotherapy [2,4,6,14]. IMRT studies dealing with a heterogeneous patient collective including paranasal sinus cancers were applying systemic therapy in 0 to and 17% [7][8][9][10][11]15].…”

“…Surgical removal often implies complex reconstruction which may end in disfiguring results and consecutively essential impairment of quality of life. Radiation therapy (RT) can be carried out as external beam or brachytherapy, with good local control rates of 67-92% after 5 years [2][3][4][5][6].…”