Squamous cell carcinoma of the nasal vestibule 1993–2002: A nationwide retrospective study from DAHANCA

Agger, Andreas; Buchwald, Christian von; Madsen, Anders Rørbæk; Yde, Jesper Borchorst; Lesnikova, Iana; Christensen, Christa Lykke; Foghsgaard, Søren; Christensen, Thomas Broe; Hansen, Hanne Sand; Larsen, Stine Rosenkilde; Bentzen, Jens; Andersen, Elo; Andersen, Lisbeth Juhler; Grau, Cai

doi:10.1002/hed.21132

Cited by 69 publications

(108 citation statements)

References 64 publications

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“…Agger et al reported that 174 cases of SCC-NV were recorded during a 10-year period in Denmark, with an annual incidence of 0.32 per 100,000 habitants [1]. There appears to be an increased risk associated with smoking tobacco [1], and both patients are smokers in this study.…”

Section: Discussionsupporting

confidence: 50%

“…Kummer et al [2] reported that all of three patients with tumors classified as T3 according to the Wang system died from the disease (2, local; 1, distant). Agger et al reported that T2 and T3 Wang tumors had poor prognoses, with a 5-year disease-specific survival of 63 and 39 % and an overall survival of 43 and 0 %, respectively [1]. In early SCC-NV, radiation therapy and surgery achieve more or less equal treatment results.…”

Section: Discussionmentioning

confidence: 99%

“…Agger et al reported the annual incidence as 0.32 per 100,000 habitants in Denmark [1]. However, it has a significant impact on the quality of life, even in early localized disease, when treated surgically [2].…”

Section: Introductionmentioning

confidence: 99%

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Rapid superselective high-dose cisplatin infusion with concomitant radiotherapy for squamous cell carcinoma of the nasal vestibule: a report of two cases

et al. 2012

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Squamous cell carcinoma of the nasal vestibule (SCC-NV) is rare among head and neck malignancies. It behaves differently from cancers arising in the nasal cavity and paranasal sinuses, and skin cancer of the external nose. Prognosis is more favorable than nasal cavity tumors and less favorable than skin cancers. We experienced two cases of SCC-NV who were treated with rapid superselective high-dose cisplatin infusion with concomitant radiotherapy (RADPLAT). A 56-year-old male and a 68-year-old female with SCC-NV, classified as T4aN0M0 according to UICC and T2 according to Wang classification, were given superselective intra-arterial infusions of cisplatin, with simultaneous intravenous infusions of thiosulfate to neutralize cisplatin toxicity, together with conventional radiotherapy. In both cases, the internal maxillary artery and the facial artery were considered to be feeders of the tumor. No serious adverse events have been observed in either patient to date during follow-up of 7.3 and 5.3 years, respectively. Both patients are alive without disease and show excellent cosmetic results. RADPLAT is considered to be useful for the treatment of patients with SCC of the nasal vestibule.

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

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Rapid superselective high-dose cisplatin infusion with concomitant radiotherapy for squamous cell carcinoma of the nasal vestibule: a report of two cases

et al. 2012

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“…They display a natural history similar to that of skin cancers and their prognosis is more favorable compared with other cancers of the nasal cavity (9). Nasal vestibular carcinomas are often located in the nasal floor, the nasal dome, the medial crus of the lower lateral cartilage and the inner lining of the alar wing (lateral crus), and account for <3.8% of all nasal mucosal tumors and 1% of all malignant tumors of the head and neck (10)(11)(12). Human papillomavirus infection and smoking are considered to be risk factors (12).…”

Section: Discussionmentioning

confidence: 99%

“…Nasal vestibular carcinomas are often located in the nasal floor, the nasal dome, the medial crus of the lower lateral cartilage and the inner lining of the alar wing (lateral crus), and account for <3.8% of all nasal mucosal tumors and 1% of all malignant tumors of the head and neck (10)(11)(12). Human papillomavirus infection and smoking are considered to be risk factors (12). However, their prognosis remains better compared with that of other sinonasal malignant tumors, such as maxillary sinus and frontal sinus malignant tumor (13,14).…”

Section: Discussionmentioning

confidence: 99%

Synchronous double primary cancer of the lung and nasal vestibule: A case report and literature review

Zang

Wang

et al. 2016

Molecular and Clinical Oncology

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Abstract. Squamous cell carcinoma (SCC) of the nasal vestibule is a rare tumor entity, and its occurrence combined with lung cancer is even rarer. Thus, several patients are often initially misdiagnosed or remain undiagnosed. This is the case report of a 55-year-old male patient who presented to our hospital with a neoplasm in the left lung. The patient was treated with left upper pulmonary lobectomy and the subsequent histopathological examination of the surgical specimen revealed a poorly differentiated SCC. On postoperative week 4, the patient presented with purulent and bloody discharge from the left nostril and was misdiagnosed with an upper jaw cyst. After another 3 weeks, the patient was re-admitted to the hospital with a mass of left nostril and nasal congestion. Tru-Cut biopsies from the nasal area and histopathological examination revealed a moderately differentiated SCC. According to the clinical presentation and the histopathological findings, the patient was diagnosed with double primary cancer of the lung and the nasal vestibule. The mass of the left nostril was significantly reduced in size with radiotherapy. To the best of our knowledge, there is no similar case previously reported in the literature. Due to the rarity of SCC of the nasal vestibule concomittant with lung cancer, we herein present this case report with a review of the relevant literature and investigation of the clinical characteristics. IntroductionMultiple primary cancers are defined as ≥2 separate original cancers, simultaneously or successively occurring in the same or different organs. Double primary cancer is the most common type of multiple primary cancer and it is classified as synchronous carcinoma (SC) and metachronous carcinoma (MC). SC is used to describe the second primary tumor when it is diagnosed simultaneously or within 6 months of the diagnosis of the first primary tumor. MC is is used to describe the second cancer when it is diagnosed >6 months after the first primary cancer (1). The first double primary cancer was reported in 1889 by Billroth (2), whose standard of the diagnosis was that each tumor should have a different localization and independent histological appearance. In 1932, Warren and Gates established new criteria, which are still applied today: i) Both cancers must be definitively malignant according to the histopathological examination; ii) the cancers must be histologically different; and iii) it must be established that the second cancer is not a metastatic lesion of the first (3). The incidence of multiple primary cancers appears to have increased significantly. Approximately 10% of cancer patients develop another primary cancer within 10 years of the first surgery (4). However, double primary cancer of the lung and nasal vestibule is uncommon. We herein describe an extremely rare case of synchronous double primary cancer involving the left nasal vestibule and the left lung, with a review of the literature. Case reportA 55-year-old man presented to the Qianfoshan Hospital on April 8, 2015, where ...

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Lymph node metastasis in nasal vestibule cancer: A review

et al. 2010

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Squamous cell carcinoma of the nasal vestibule 1993–2002: A nationwide retrospective study from DAHANCA

Cited by 69 publications

References 64 publications

Rapid superselective high-dose cisplatin infusion with concomitant radiotherapy for squamous cell carcinoma of the nasal vestibule: a report of two cases

Rapid superselective high-dose cisplatin infusion with concomitant radiotherapy for squamous cell carcinoma of the nasal vestibule: a report of two cases

Synchronous double primary cancer of the lung and nasal vestibule: A case report and literature review

Lymph node metastasis in nasal vestibule cancer: A review

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