Interstitial lung abnormality (ILA) and nonspecific interstitial pneumonia (NSIP)

Hino, Takuya; Lee, Kyung Soo; Yoo, Hyuk Sang; Han, Joungho; Franks, Teri J.; Hatabu, Hiroto

doi:10.1016/j.ejro.2021.100336

Cited by 13 publications

(6 citation statements)

References 94 publications

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“…Chronic diseases related to smoking identified in previous LCS studies, and commonly found on chest CT, include osteoporosis and pulmonary (emphysema and interstitial lung abnormalities (ILAs)) and cardiovascular disease [ 7 – 9 ]. ILAs are non-dependent abnormalities identified incidentally in patients without clinical suspicion of interstitial lung disease (ILD), when ILD may be compatible with these abnormalities [ 10 , 11 ]. Furthermore, there are subcategories of ILAs including: non-subpleural, subpleural non-fibrotic and subpleural fibrotic [ 9 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Computed tomography on lung cancer screening is useful for adjuvant comorbidity diagnosis in developing countries

et al. 2022

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PurposeTo analyze and quantify the prevalence of six comorbidities from lung cancer screening (LCS) on computed tomography (CT) scans of patients from developing countries.MethodsFor this retrospective study, low-dose CT scans (n=775) from patients who underwent LCS in a tertiary hospital between 2016 and 2020 were examined. Age and sex- matched control group was obtained for comparison (n=370). Using the software, coronary artery calcification (CAC), the skeletal muscle area (SMA), interstitial lung abnormalities (ILAs), emphysema, osteoporosis, and hepatic steatosis was accessed. Clinical characteristics of each participant were identified. t-test and chi-squared test were used to examine differences between these values. Interclass correlation coefficients (ICCs) and Interobserver agreement (assessed by calculating kappa coefficients) were calculated to assess the correlation of measures interpreted by two observers. p values<0.05 were considered significant.ResultsOne or more comorbidities were identified in 86.6% of the patients and in 40% of the controls. The most prevalent comorbidity was osteoporosis, present in 44.2% of patients and on 24.8% of the controls. New diagnoses of cardiovascular disease, emphysema, and osteoporosis were made in 25%, 7%, and 46% of cases, respectively. The kappa coefficient for CAC was 0.906 (p<0.001). ICCs for measures of liver, spleen, and bone density were 0.88, 0.93, and 0.96, respectively (p<0.001).ConclusionsCT data acquired during LCS led to the identification of previously undiagnosed comorbidities. The LCS is useful to facilitate comorbidity diagnosis in developing countries, providing opportunities for its prevention and treatment.

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Section: Introductionmentioning

confidence: 99%

“…ILAs are non-dependent abnormalities identified incidentally in patients without clinical suspicion of interstitial lung disease (ILD), when ILD may be compatible with these abnormalities [ 10 , 11 ]. Furthermore, there are subcategories of ILAs including: non-subpleural, subpleural non-fibrotic and subpleural fibrotic [ 9 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Computed tomography on lung cancer screening is useful for adjuvant comorbidity diagnosis in developing countries

et al. 2022

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“…iNSIP is characterized by diffuse GGOs generally associated with reticulation and bronchiectasis involving mainly lower lobes. Subpleural sparing is often present, while honeycombing is rare (4.7%) [211]. In COP, the presence of sub-pleural or peribronchial consolidation areas with concurrent GGOs, band-like signs, perilobular patterns and reversed halo signs are commonly detected in thoracic HRCT scans [212].…”

Section: Clinico-radiological and Prognostic Featuresmentioning

confidence: 99%

Multidisciplinary Approach to the Diagnosis of Idiopathic Interstitial Pneumonias: Focus on the Pathologist’s Key Role

Lucà,

Pagliuca,

Perrotta

et al. 2024

IJMS

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Idiopathic Interstitial Pneumonias (IIPs) are a heterogeneous group of the broader category of Interstitial Lung Diseases (ILDs), pathologically characterized by the distortion of lung parenchyma by interstitial inflammation and/or fibrosis. The American Thoracic Society (ATS)/European Respiratory Society (ERS) international multidisciplinary consensus classification of the IIPs was published in 2002 and then updated in 2013, with the authors emphasizing the need for a multidisciplinary approach to the diagnosis of IIPs. The histological evaluation of IIPs is challenging, and different types of IIPs are classically associated with specific histopathological patterns. However, morphological overlaps can be observed, and the same histopathological features can be seen in totally different clinical settings. Therefore, the pathologist’s aim is to recognize the pathologic–morphologic pattern of disease in this clinical setting, and only after multi-disciplinary evaluation, if there is concordance between clinical and radiological findings, a definitive diagnosis of specific IIP can be established, allowing the optimal clinical–therapeutic management of the patient.

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“…Thickening of alveolar walls is even, fibrotic foci typical of UIP cannot be distinguished, and the lung architecture is preserved [6]. HRCT reveals: symmetrical foci of ground-glass opacities, reticular opacities and, in advanced stages, traction bronchiectasis and reduced lobe volumes, especially in the parabasal regions of the lungs [6,7]. Depending on the dominant type of lesions, NSIP can be divided into cellular (inflammatory) NSIP, characterised by both better prognosis and better response to treatment, and fibrotic NSIP, in which fibrosis is dominant and which can be similar to UIP in terms of clinical picture and prognosis.…”

Section: Nonspecific Interstitial Pneumoniamentioning

confidence: 99%

Interstitial lung disease in the course of systemic connective tissue diseases: A common problem for rheumatologists and pulmonologists

Gogulska

Smoleńska²,

Szymanowska-Narloch³

et al. 2022

Rheumatology Forum

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Interstitial lung disease is a common and dangerous complication of many rheumatic diseases. Progress over the last several years has increased diagnostic capabilities, led to emergence of new therapeutic options and, above all, resulted in deeper awareness of the severity of the problem. Interstitial diseases are a heterogeneous group differentiated through histo-pathological and imaging examinations. Prognosis and recommended therapy depend not only on the form of the interstitial disease, but also largely on its underlying rheumatic disease. The aim of this article is to present the pathology that is the interstitial lung disease and the current knowledge on its treatment.

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Interstitial lung abnormality (ILA) and nonspecific interstitial pneumonia (NSIP)

Cited by 13 publications

References 94 publications

Computed tomography on lung cancer screening is useful for adjuvant comorbidity diagnosis in developing countries

Computed tomography on lung cancer screening is useful for adjuvant comorbidity diagnosis in developing countries

Multidisciplinary Approach to the Diagnosis of Idiopathic Interstitial Pneumonias: Focus on the Pathologist’s Key Role

Interstitial lung disease in the course of systemic connective tissue diseases: A common problem for rheumatologists and pulmonologists

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