Interstitial lung abnormalities and self-reported health and functional status

Axelsson, Gísli Thor; Putman, Rachel K.; Araki, Toshimitsu; Sigurðsson, Sigurður; Guðmundsson, Elías F.; Eiríksdóttir, Guðný; Aspelund, Thor; Miller, Ezra R.; Launer, Lenore J.; Harris, Tamara B.; Hatabu, Hiroto; Gudnason, Vilmundur; Hunninghake, Gary M.; Guðmundsson, Gunnar

doi:10.1136/thoraxjnl-2017-210956

Cited by 22 publications

(13 citation statements)

References 9 publications

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“…Both these suggestions are interesting, especially when viewed in the context of previous reports of people with ILA having an increased risk of mortality [13] and worse subjectively assessed health [5]. Future longitudinal studies exploring the timing of these associations would be of interest.…”

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confidence: 93%

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Interstitial lung abnormalities and physical function

et al. 2018

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The term interstitial lung abnormalities (ILA) was coined to define a precursory stage of idiopathic pulmonary fibrosis and encompasses a set of radiological changes seen in interstitial lung diseases (ILD) but are often of lesser magnitude [1]. ILA have been associated with age, many environmental and genetic risk factors and pulmonary symptoms of idiopathic pulmonary fibrosis [1, 2]. ILA have also been associated with reduced exercise capacity and self-reported health and function [3–5].

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confidence: 93%

“…ILA have been associated with age, many environmental and genetic risk factors and pulmonary symptoms of idiopathic pulmonary fibrosis [ 1 , 2 ]. ILA have also been associated with reduced exercise capacity and self-reported health and function [ 3 – 5 ].…”

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Interstitial lung abnormalities and physical function

et al. 2018

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“…Importantly, ILA are associated with reduced lung function and exercise capacity, and increased risk of all-cause and respiratory mortality [ 1 , 9 , 10 , 11 ]. Furthermore, several recent studies linked ILA to increased risk for progressive pulmonary fibrosis, lung cancer and lung cancer-associated mortality [ 12 ].…”

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confidence: 99%

Circulating microRNA Signature Associated to Interstitial Lung Abnormalities in Respiratory Asymptomatic Subjects

Ortiz‐Quintero

Buendía-Roldán

Ramírez‐Salazar

et al. 2020

Cells

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Interstitial lung abnormalities (ILA) are observed in around 9% of older respiratory asymptomatic subjects, mainly smokers. Evidence suggests that ILA may precede the development of interstitial lung diseases and may evolve to progressive fibrosis. Identifying biomarkers of this subclinical status is relevant for early diagnosis and to predict outcome. We aimed to identify circulating microRNAs (miRNAs) associated to ILA in a cohort of respiratory asymptomatic subjects older than 60 years. We identified 81 subjects with ILA from our Lung-Aging Program in Mexico City (n = 826). We randomly selected 112 subjects without ILA (Ctrl) from the same cohort. Using polymerase chain reaction PCR-Array technology (24 ILA and 24 Ctrl, screening cohort) and reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR) (57 ILA and 88 Ctr, independent validation cohort) we identified seven up-regulated miRNAs in serum of ILA compared to Ctrl (miR-193a-5p, p < 0.0001; miR-502-3p, p < 0.0001; miR-200c-3p, p = 0.003; miR-16-5p, p = 0.003; miR-21-5p, p = 0.002; miR-126-3p, p = 0.004 and miR-34a-5p, p < 0.005). Pathways regulated by these miRNAs include transforming growth factor beta (TGF-β), Wnt, mammalian target of rapamycin (mTOR), Insulin, mitogen-activated protein kinase (MAPK) signaling, and senescence. Receiver operator characteristic (ROC) curve analysis indicated that miR-193a-5p (area under the curve AUC: 0.75) and miR-502-3p (AUC 0.71) have acceptable diagnostic value. This is the first identification of circulating miRNAs associated to ILA in respiratory asymptomatic subjects, providing potential non-invasive biomarkers and molecular targets to better understand the pathogenic mechanisms associated to ILA.

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“…Although the significance of ILA is not clearly defined, studies have found associated decrements in exercise capacity, reduced health and functional status, decline in lung function and increased risk of all-cause mortality and pulmonary fibrosis specific mortality. [4][5][6][7][8][9] Detection of ILA in populations receiving CT scans for other reasons may provide much needed insights into the natural history of fibrotic lung disease and inform the discussion about indications for treatment.…”

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confidence: 99%

Interstitial lung abnormalities in the Queensland Lung Cancer Screening Study: prevalence and progression over 2 years of surveillance

Mackintosh

Marshall

Slaughter

et al. 2019

Internal Medicine Journal

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Background We report the prevalence and progression of incidentally detected interstitial lung abnormalities (ILA) in the Queensland Lung Cancer Screening Study cohort. Methods About 256 volunteers aged 60–74, with ≥30 pack years smoking history and forced expiratory volume in 1 s (FEV1) ≥50% predicted underwent low‐dose computed tomography (CT) chest screening. Electronic search of baseline (T0) and 2‐year follow‐up (T2) CT reports identified candidate cases using Fleischner Society interstitial terminology. Candidate CT were reviewed in a randomised order by two experienced radiologists and a senior respiratory medicine trainee blinded to the existing reports. Scans were evaluated for the presence and extent of ILA using an in‐house score, and graded for progression. Results ILA were detected in 20/256 baseline cases (7.8%) with no incident cases detected at T2 surveillance imaging. Of these 20 cases, 9 (45%) had reticulation, 18 (90%) had ground glass change, 1 had traction bronchiectasis and 1 had randomly distributed nodularity. Seven cases with ground glass changes also had areas of reticulation, and only two had reticulation alone. All ILA were graded as minor except for traction bronchiectasis, which was moderate. Only one case progressed on T2 imaging. ILA were associated with the presence of auscultatory crackles (50% vs 11.6%, P = 0.001) and a lesser degree of emphysema (mean % volumetric emphysema 6.7% vs 9.8%, P = 0.009). No relationship was observed between baseline and serial lung function parameters. Conclusion ILA are frequent incidental findings in lung cancer screening. In the majority of cases these abnormalities do not appear to change significantly over a 2‐year period of surveillance.

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Interstitial lung abnormalities and self-reported health and functional status

Cited by 22 publications

References 9 publications

Interstitial lung abnormalities and physical function

Interstitial lung abnormalities and physical function

Circulating microRNA Signature Associated to Interstitial Lung Abnormalities in Respiratory Asymptomatic Subjects

Interstitial lung abnormalities in the Queensland Lung Cancer Screening Study: prevalence and progression over 2 years of surveillance

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