Interstitial lung abnormalities and physical function

Axelsson, Gísli Thor; Putman, Rachel K.; Miller, Ezra R.; Araki, Toshimitsu; Sigurðsson, Sigurður; Guðmundsson, Elías F.; Eiríksdóttir, Guðný; Siggeirsdóttir, Kristín; Aspelund, Thor; Launer, Lenore J.; Harris, Tamara B.; Hatabu, Hiroto; Gudnason, Vilmundur; Hunninghake, Gary M.; Guðmundsson, Gunnar

doi:10.1183/23120541.00057-2018

Cited by 11 publications

(7 citation statements)

References 15 publications

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“…These findings are similar to those reported in other cohorts, such as COPDGene, ECLIPSE, and AGES-Reykjavik, where asymptomatic subjects with ILAs presented poor pulmonary function compared to clinically healthy subjects [ 2 , 19 , 20 ]. In addition, we compared the subpleural ILA pattern vs. HC, and the results were comparable with the whole ILA group, similar to the previous report by Axelsson et al [ 21 ].…”

Section: Discussionsupporting

confidence: 87%

The HLA-DRB1*07 Allele Is Associated with Interstitial Lung Abnormalities (ILA) and Subpleural Location in a Mexican Mestizo Population

et al. 2022

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Interstitial lung abnormalities (ILA) are defined as the presence of different patterns of increased lung density, including ground glass attenuation and reticular opacities on chest high-resolution computed tomography (HRCT). In this study, we included 90 subjects with ILA and 189 healthy controls (HC) from our Aging Lung Program. We found that subjects with ILA are older, have a significant smoking history, and have worse pulmonary function than HC (p < 0.05). When we evaluated the allele frequencies of the human leukocyte antigen (HLA) system, we found that HLA-DRB1*07 was associated with a higher risk for ILA (p < 0.05, OR = 1.95, 95% CI = 1.06–3.57). When we compared subjects with subpleural ILA vs. HC, the association with HLA-DRB1*07 became stronger than the whole ILA group (p < 0.05, OR = 2.29, 95% CI = 1.24–4.25). Furthermore, subjects with subpleural ILA and central ILA display differences in allele frequencies with HLA-DRB1*14 (3.33% vs. 13.33%, p < 0.05) and *15 (3.33% vs. 20%, p < 0.05). Our findings indicate that the HLA-DRB1*07 allele contributes to the risk of ILA, especially those of subpleural locations.

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Section: Discussionsupporting

confidence: 87%

The HLA-DRB1*07 Allele Is Associated with Interstitial Lung Abnormalities (ILA) and Subpleural Location in a Mexican Mestizo Population

et al. 2022

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“…While associations with COPD differ, ILA have been positively associated with paraseptal emphysema, a subtype of emphysema that is not associated with airflow obstruction and is of largely unknown clinical significance [ 54 ]. What’s more, an increased risk of acute respiratory distress syndrome (ARDS) among critically ill patients in the intensive care setting has been linked with ILA [ 55 ], smokers with ILA have been shown to have decreased 6-minute walking distance [ 56 ] and participants with ILA in a general-population cohort had worse performance in various tests of decreased physical function and worse self-reported health and functional status than their peers [ 57 , 58 ].…”

Section: Clinical Outcomesmentioning

confidence: 99%

Interstitial lung abnormalities – current knowledge and future directions

Axelsson

Guðmundsson

2021

European Clinical Respiratory Journal

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“…However, large cohort studies have reported prevalence of 2–10% [ 2 – 5 ] and a higher risk of mortality [ 2 , 6 ]. ILAs have been shown to be associated with symptoms including breathlessness, reductions in lung function [ 2 ] and exercise capacity [ 7 ] and genetic abnormalities common to familial interstitial pneumonia and idiopathic pulmonary fibrosis (IPF) [ 8 , 9 ]. A proportion of ILAs are known to progress to IPF, yet ILA prevalence exceeds that of IPF by a considerable margin.…”

Section: Introductionmentioning

confidence: 99%

Increased monocyte level is a risk factor for radiological progression in patients with early fibrotic interstitial lung abnormality

Achaiah

Lyon²,

Fraser³

et al. 2022

ERJ Open Res

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BackgroundInterstitial lung abnormalities (ILA) are specific spatial patterns on computed tomography scan (CT), potentially compatible with early interstitial lung disease (ILD). A proportion will progress; management involves risk stratification and surveillance. Elevated blood monocyte levels have been shown to associate with progression of IPF.AimsTo (i) estimate the proportion of “early fibrotic” ILAs (EF-ILA; reticular +/− ground glass opacities, excluding traction bronchiectasis and honeycombing) on CTs of patients attending all-indications thoracic CTs, and proportion demonstrating radiological progression and (ii) explore association between peripheral blood leukocyte levels and ILA progression.MethodsWe analysed all thoracic CT reports in individuals aged 45–75 performed between January-2015 and December-2020 in one large teaching hospital (Oxford, UK) to identify patient CT reports consistent with EF-ILA. CT-contemporaneous blood leukocyte counts were examined to explore contribution to progression and all-cause mortality, using multivariate Cox regression.Results40 711 patients underwent thoracic CT imaging during this period. 1259 (3.1%) demonstrated the EF-ILA pattern. Mean age; 65.4 (±7.32), male; 735 (47.8%). EF-ILA was significantly associated with all-cause mortality [HR 1.87, 95%CI 1.25–2.78, p=0.002]. 362 cases underwent at least one follow-on CT. Radiological progression was observed in 157 cases (43.4%); increase in reticulation; 51, new traction bronchiectasis; 84, and honeycombing; 22. Monocyte count, neutrophil count, monocyte:lymphocyte ratio, neutrophil:lymphocyte ratio and 'systemic inflammatory response index' were significantly associated with radiological progression.Conclusion3.1% of subjects requiring thoracic CT during a 6-year period demonstrated EF-ILA. Monocyte levels, and blood leukocyte-derived indexes were associated with radiological progression and could indicate which patients may require closer follow up.

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Interstitial lung abnormalities and physical function

Cited by 11 publications

References 15 publications

The HLA-DRB1*07 Allele Is Associated with Interstitial Lung Abnormalities (ILA) and Subpleural Location in a Mexican Mestizo Population

The HLA-DRB1*07 Allele Is Associated with Interstitial Lung Abnormalities (ILA) and Subpleural Location in a Mexican Mestizo Population

Interstitial lung abnormalities – current knowledge and future directions

Increased monocyte level is a risk factor for radiological progression in patients with early fibrotic interstitial lung abnormality

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