Interstitial laser treatment of malignant tumours: initial experience

Tranberg, Karl‐Göran; Möller, Páll Helgi; Hannesson, Pétur; Stenram, Unne

doi:10.1016/s0748-7983(96)91451-1

Cited by 54 publications

(29 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6,7 Temporary interruption of hepatic blood flow by occlusion of hepatic inflow vessels (Pringle maneuver) during LITT has been proven to increase its efficacy. 8 -11 The Pringle maneuver usually requires laparotomy 10,11 or at least laparoscopy 12 and may therefore be difficult to repeat in cases of insufficient therapy. LITT, however, can be applied percu-taneously without laparotomy or laparoscopy and can thus be easily repeated.…”

Section: Discussionmentioning

confidence: 99%

“…Pilot clinical studies show that LITT is effective in achieving local control of liver tumors. 2,10 Despite these promising results, the clinical application of LITT is still limited. One major problem of LITT is insufficient tumor destruction because of the limited size of the inducible coagulation necroses.…”

Section: Discussionmentioning

confidence: 99%

“…15,19,20 One of these approaches is the temporary interruption of hepatic blood flow by clamping the hepatic inflow vessels during LITT to prevent the so-called cooling effect of blood flow. 7,11 However, this usually requires laparotomy 10 or at least laparoscopy, 12 whereas LITT can be applied percutaneously.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Laser-Induced Thermotherapy Combined With Hepatic Arterial Embolization in the Treatment of Liver Tumors in a Rat Tumor Model

Germer¹,

Isbert²,

Albrecht³

et al. 1999

Annals of Surgery

View full text Add to dashboard Cite

ObjectiveTo assess the effect of combined laser-induced thermotherapy (LITT) and hepatic arterial embolization with degradable starch microspheres (DSM) on tumor response and intrahepatic temperature distribution in rats with liver tumors. Summary Background DataLaser-induced thermotherapy is a promising in situ ablation technique for malignant liver tumors. However, clinical use is still limited, mainly because of the small size of the inducible coagulation necroses. This results in insufficient tumor destruction. MethodsColon carcinoma CC531 was implanted in 60 WAG rat livers. Fourteen days later, a silicon catheter was implanted in the hepatic artery for DSM administration. Tumors were exposed to 1064 nm Nd:YAG laser light at 2 watts for 10 minutes from a diffuser tip applicator placed in the tumor. The animals were randomized into a sham-operated control (group I) and three test groups. Group II received DSM alone, group III received LITT alone, and group IV received DSM ϩ LITT. Tumor control was examined 1, 7, and 14 days after treatment. ResultsA complete tumor remission was achieved in all rats treated with LITT ϩ DSM (group IV). In contrast, tumor progression was seen in animals treated with LITT alone (group III) or DSM alone (group II), as well as in the sham-operated controls (group I). ConclusionsThe authors' results suggest that the combination of LITT and DSM considerably increases the efficacy of LITT in the treatment of liver metastases in the rat.Laser-induced thermotherapy (LITT) or interstitial laser thermotherapy is an in situ ablation technique for the treatment of malignant tumors of the liver.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Laser-Induced Thermotherapy Combined With Hepatic Arterial Embolization in the Treatment of Liver Tumors in a Rat Tumor Model

Germer¹,

Isbert²,

Albrecht³

et al. 1999

Annals of Surgery

View full text Add to dashboard Cite

show abstract

“…Interstitial laser thermotherapy (ILT) is a method for local destruction of malignant tumors in the liver [1][2][3][4][5], pancreas, breast, and brain [6][7][8]. Laser-induced coagulation is also a promising technique for treatment of benign prostatic hyperplasia [9][10][11] and menorrhagia [12].…”

Section: Introductionmentioning

confidence: 99%

Simplified treatment planning for interstitial laser thermotherapy by disregarding light transport: A numerical study

et al. 1999

View full text Add to dashboard Cite

“…One of the advantages of local tissue destruction is that the trauma is small compared with surgery. It has been shown that interstitial laser thermotherapy induces well-defined and reproducible liver necrosis and that it may be efficient in local treatment of liver tumours (Amin et al, 1993;van Hillegersberg et al, 1994;Moller et al, 1996Moller et al, , 1997Tranberg et al, 1996).…”

mentioning

confidence: 99%

Comparison between interstitial laser thermotherapy and excision of an adenocarcinoma transplanted into rat liver

Möller

Ivarsson²,

Stenram³

et al. 1998

Br J Cancer

View full text Add to dashboard Cite

Summary The aim of this study was to compare interstitial laser thermotherapy with excision of a liver tumour. A dimethylhydrazine-induced adenocarcinoma was transplanted (implanted if not stated otherwise) into the left lateral lobe of the rat liver, and treatment was performed 8 days later. In the main experiment, rats were treated with resection of the tumour-bearing lobe or underwent interstitial laser thermotherapy, which was performed at a steady-state temperature of 460C for 30 min, 3 mm from the tumour margin. The incidence and extent of intraperitoneal spread was smaller after laser thermotherapy than after resection of the tumour-bearing lobe, with no difference in local control. Metastatic spread after resection of the median liver lobe was similar to that observed after sham procedures for thermotherapy or resection, suggesting that the advantage of thermotherapy was not due to a difference in surgical trauma. Additional studies showed that laser thermotherapy reduced intraperitoneal spread when treatment was suboptimal or in a tumour inoculation model and suggested that immunological mechanisms might be involved. It is concluded that interstitial laser thermotherapy reduces spread of liver tumour compared with resection.

show abstract

Interstitial laser treatment of malignant tumours: initial experience

Cited by 54 publications

References 31 publications

Laser-Induced Thermotherapy Combined With Hepatic Arterial Embolization in the Treatment of Liver Tumors in a Rat Tumor Model

Laser-Induced Thermotherapy Combined With Hepatic Arterial Embolization in the Treatment of Liver Tumors in a Rat Tumor Model

Simplified treatment planning for interstitial laser thermotherapy by disregarding light transport: A numerical study

Comparison between interstitial laser thermotherapy and excision of an adenocarcinoma transplanted into rat liver

Contact Info

Product

Resources

About