Interstitial granulomatous dermatitis and arthritis revealing oesophageal carcinoma

Abstract

Interstitial granulomatous dermatitis and arthritis (IGDA) is an uncommon clinicopathological condition that may occur in association with a number of systemic disorders. We present a novel case of IGDA in association with oesophageal squamous cell carcinoma (SCC). A 67-year-old man with a 3-month history of arthritis presented with several erythematous indurated plaques on his lateral trunk and arms. An oesophagogastroduodenoscopy showed an irregular mass 20 mm in size in the proximal third of the oesophagus, and on histopathological examination of a biopsy, the mass was identified as a poorly differentiated SCC. Histopathological examination of a skin biopsy found features consistent with interstitial granulomatous dermatitis. The combination of clinicopathological correlation and laboratory findings led to the diagnosis of IGDA. This association has not been previously described, to our knowledge.

Interstitial Granulomatous Dermatitis in a Patient with Prostate Cancer

“…As the skin lesions improved after the remission of prostate cancer, it could be possible that IGD is associated with prostate cancer in our patient. Previous cases of IGD in association with solid tumor have also shown flares and improvement of clinical signs in accordance to the tumor state31112. In the case of IGDA disclosing lung cancer, four weeks after surgical removal of the tumor, the clinical signs disappeared11.…”

“…Schreckenberg et al11 have revealed a case of interstitial granulomatous dermatitis and arthritis (IGDA) disclosing lung cancer. Moyano Almagro et al12 have also reported a case of IGDA disclosing esophageal cancer. IGDA disclosing malignant neoplasm in both cases may suggest paraneoplastic phenomenon1112.…”

“…Moyano Almagro et al12 have also reported a case of IGDA disclosing esophageal cancer. IGDA disclosing malignant neoplasm in both cases may suggest paraneoplastic phenomenon1112. Peroni et al3 have reported three patients with IGD who had cancer (hypopharyngeal cancer, breast cancer, and endometrial cancer, respectively) without articular symptoms.…”

“…In a case of IGD with hypopharyngeal SCC, after the administration of systemic steroids, chemotherapy, and radiotherapy, there was complete remission of the skin lesions3. In contrast, in the case of IGDA disclosing esophageal cancer, due to tumor progression, the cutaneous lesions failed to improve despite systemic steroids, radiotherapy, and chemotherapy12.…”

Disseminated interstitial granuloma annulare associated with hepatocellular carcinoma

“…In our case, the patient's disseminated interstitial GA was associated with HC. While there is little information linking GA to HCC, the literature supports an association between GA and prostate, pulmonary, cervical, oesophageal and breast carcinoma as well as mycosis fungoides, HL, and leukaemia . Despite these associations, very few cases of GA have been proven to be a true paraneoplastic phenomenon .…”