Interstitial Doppler optical coherence tomography

Yang, Victor X. D.; Mao, You X.; Munce, Nigel R.; Standish, Beau A.; Kucharczyk, Walter; Marcon, Norman E.; Wilson, Brian C.; Vitkin, I. Alex

doi:10.1364/ol.30.001791

Cited by 79 publications

(43 citation statements)

References 14 publications

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“…37 Needle-based OCT catheters have been developed. [38][39][40][41][42][43] Needle-based devices require fl exibility to be compatible with standard bronchoscopes and/or TBNA needles. The previously developed OCT catheters are not capable of imaging and acquiring tissue through the same needle.…”

Section: Oct Criteria Development For Spn and Lung Parenchymamentioning

confidence: 99%

Toward the Guidance of Transbronchial Biopsy

Hariri

Mino‐Kenudson

Applegate

et al. 2013

Chest

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Background: Solitary pulmonary nodules (SPNs) frequently require transbronchial needle aspiration (TBNA) or biopsy to determine malignant potential, but have variable diagnostic yields. Confi rming needle placement within SPNs during TBNA could signifi cantly increase diagnostic yield. Optical coherence tomography (OCT) provides nondestructive, high-resolution, microstructural imaging with potential to distinguish SPN from parenchyma. We have developed needle-based OCT probes compatible with TBNA. Before OCT can play any signifi cant role in guiding clinical TBNA, OCT interpretation criteria for differentiating SPN from lung parenchyma must be developed and validated. Methods: OCT of SPN and parenchyma was performed on 111 ex vivo resection specimens. OCT criteria for parenchyma and SPN were developed and validated in a blinded assessment. Six blinded readers (two pulmonologists, two pathologists, and two OCT experts) were trained on imaging criteria in a 15-min training session prior to interpreting the validation data set. Results: OCT of lung parenchyma displayed evenly spaced signal-void alveolar spaces, signal-intense backrefl ections at tissue-air interfaces, or both. SPNs lacked both of these imaging features. Independent validation of OCT criteria by the six blinded readers demonstrated sensitivity and specifi city of 95.4% and 98.2%, respectively. Conclusions: We have developed and validated OCT criteria for lung parenchyma and SPN with sensitivity and specifi city . 95% in this ex vivo study. We anticipate that OCT could be a useful complementary imaging modality to confi rm needle placement during TBNA to potentially increase diagnostic yield. CHEST 2013; 144(4):1261-1268Abbreviations: OCT 5 optical coherence tomography; SPN 5 solitary pulmonary nodule; TBNA 5 transbronchial needle aspiration; TB-OCT 5 transbronchial optical coherence tomography

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Section: Oct Criteria Development For Spn and Lung Parenchymamentioning

confidence: 99%

Toward the Guidance of Transbronchial Biopsy

Hariri

Mino‐Kenudson

Applegate

et al. 2013

Chest

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“…Other important technical characteristics of an OCT probe are scanning range, field of view, speed, and flexibility. OCT probes can be divided into two groups based on their scan modes-side-imaging 37,[89][90][91][92][93][94][95][96][97] and forward-imaging probes. 38,[98][99][100][101][102][103][104][105][106][107] In the past years, various OCT probes have been built to target specific applications, which we will discuss below.…”

Section: Survey Of Endoscopic Oct Methodsmentioning

confidence: 99%

Methods and application areas of endoscopic optical coherence tomography

et al. 2006

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Abstract. We review the current state of research in endoscopic optical coherence tomography ͑OCT͒. We first survey the range of available endoscopic optical imaging techniques. We then discuss the various OCT-based endoscopic methods that have thus far been developed. We compare the different endoscopic OCT methods in terms of their scan performance. Next, we examine the application range of endoscopic OCT methods. In particular, we look at the reported utility of the methods in digestive, intravascular, respiratory, urinary and reproductive systems. We highlight two additional applications-biopsy procedures and neurosurgery-where sufficiently compact OCTbased endoscopes can have significant clinical impacts.

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“…An advantage of this technique is that light waves, unlike sound waves, do not need a liquid based coupling medium which makes it ideal for use in the airways. OCT allows imaging of cellular and extracellular structures from analysis of the backscattered light with a spatial resolution of around 3-15 µm and a depth penetration of around 2 mm to provide near-histological images in the bronchial wall [Fujimoto et al 1995;Huang et al 1991;Lam et al 2008;Li et al 2006;Tearney et al 1997;Tsuboi et al 2005;Whiteman et al 2006;Yang and Vitkin, 2006]. Early studies showed that dysplasia can be distinguished from metaplasia, hyperplasia or normal tissue and that carcinoma in situ (CIS) can be distinguished from invasive cancer [Lam et al 2008;Tsuboi et al 2005].…”

Section: Detection Of Early Squamous Lung Cancermentioning

confidence: 99%

“…The basement membrane became disrupted or disappeared with invasive carcinoma [Lam et al 2008]. To further advance this technology, systems with higher resolution and Doppler capability that can measure both tissue microstructures in greater detail and microvascular blood flow may be useful [Yang and Vitkin, 2006]. Doppler OCT systems already exist that can detect very slow blood flow (<20 µm/s in blood vessels as small as about 15 µm diameter).…”

Section: Detection Of Early Squamous Lung Cancermentioning

confidence: 99%

Detection and minimally invasive treatment of early squamous lung cancer

Daniëls

Sutedja

2013

Ther Adv Med Oncol

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Non-small cell lung cancer (NSCLC) is the most common cause of cancer deaths worldwide. The majority of patents presenting with NSCLC have advanced disease, which precludes curative treatment. Early detection and treatment might result in the identification of more patients with early central lung cancer and improve survival. In addition, the study of early lung cancer improves understanding of lung carcinogenesis and might also reveal new treatment targets for advanced lung cancer. Bronchoscopic investigation of the central airways can reveal both early central lung cancer in situ (stage 0) and other preinvasive lesions such as dysplasia. In the current review we discuss the detection of early squamous lung cancer, the natural history of preinvasive lesions and whether biomarkers can be used to predict progression to cancer. Finally we will review the staging and management of preinvasive lung cancer lesions and the different therapeutic modalities that are available.

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Interstitial Doppler optical coherence tomography

Cited by 79 publications

References 14 publications

Toward the Guidance of Transbronchial Biopsy

Toward the Guidance of Transbronchial Biopsy

Methods and application areas of endoscopic optical coherence tomography

Detection and minimally invasive treatment of early squamous lung cancer

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