Interstitial cells of Cajal — systematic review

Pasternak, Artur; Szura, Mirosław; Gil, Krzysztof; Matyja, Andrzej

doi:10.5603/fm.a2016.0002

Cited by 39 publications

(42 citation statements)

References 66 publications

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“…ICCs exist in the digestive tract, including in the esophagus, stomach, proximal duodenum wall, small and large bowel, ileum, appendix, and colon [6]. ICCs function as smooth muscle pacemaker cells in the digestive tract where they promote gastrointestinal electrical activity.…”

Section: Introductionmentioning

confidence: 99%

Acute Cholecystitis Reduces Interstitial Cells of Cajal in Porcine Gallbladder Through Decreased mRNA Synthesis

Huang¹,

Qiu²,

Yu³

2018

Cell Physiol Biochem

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Background/Aims: Acute cholecystitis is a common gastrointestinal disorder, often characterized by acute cholecystitis with gallbladder motility disorder. Interstitial cells of Cajal (ICCs) are the pacemaker cells of gut motility in the gastrointestinal tract. Disruption of ICC function is related to motility disorders. The aim of this study was to explore the cellular and molecular mechanisms of ICCs in acute cholecystitis and after the resolution of acute inflammation. Materials and Methods: Fifty adult guinea pigs were randomly divided into five groups: a sham-administered group (control group); two groups that were intraperitoneally administered an anti-polyclonal neutrophil (PMN) antibody 24 h before common bile duct ligation (CBDL); and two groups of guinea pigs that were subjected to CBDL without receiving the PMN antibody. Guinea pigs that underwent CBDL were held for 24 h or 48 h after surgery before being subjected to laparotomy and cholecystectomy. Immunohistochemistry, TUNEL assays, western blotting, and real-time PCR were performed to determine ICC morphology and density, to detect ICC apoptosis, and to examine stem cell factor (SCF) and c-kit protein expression and SCF and c-kit mRNA levels, respectively. Results: Both hematoxylin-eosin staining and histological inflammation scores in the PMN groups were lower than those in the control groups (P < 0.01). No differences were observed in ICC morphology between groups. During acute cholecystitis, ICCs numbers were reduced. Conversely, the density of ICCs increased after inflammation was relieved (P < 0.01). In addition, SCF and c-kit protein and mRNA expression levels decreased during acute cholecystitis (P < 0.05) and increased after inflammation was relieved (P < 0.05). Furthermore, ICC apoptosis increased during acute cholecystitis and decreased after resolution of acute cholecystitis (P < 0.01). Conclusions: In acute cholecystitis, ICC injury may be related to gallbladder motility disorder.

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Section: Introductionmentioning

confidence: 99%

Acute Cholecystitis Reduces Interstitial Cells of Cajal in Porcine Gallbladder Through Decreased mRNA Synthesis

Huang¹,

Qiu²,

Yu³

2018

Cell Physiol Biochem

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“…There is proof that the nerves in different layers of the GI wall undergo DAN changes and that the parasympathetic fibers in the gut are disrupted in DM patients[114]. Furthermore, ICCs are pacemaker cells in the GI tract distributed along the GI wall[120]. In GI tract, ICCs play an important role for the link between the autonomic nervous system, enteric neurons and smooth muscle cells[121].…”

Section: Diabetes-induced Sensory-motor Changes In the Intestine And mentioning

confidence: 99%

“…It is well known that long-term hyperglycemia can induce the formation and accumulation of AGEs which play an important role for DAN[68-70]. ICC, together ENS and smooth muscles, play an important role in the regulation of motility[120]. One study demonstrated that a high dietary saturated fat intake is associated with significant increase in the prevalence of constipation in patients with uncontrolled DM[167].…”

Section: Clinical Consequences Of Diabetes-induced Changes In Intestimentioning

confidence: 99%

Diabetes-induced mechanophysiological changes in the small intestine and colon

Zhao

Liao

Zhao

2017

WJD

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The disorders of gastrointestinal (GI) tract including intestine and colon are common in the patients with diabetes mellitus (DM). DM induced intestinal and colonic structural and biomechanical remodeling in animals and humans. The remodeling is closely related to motor-sensory abnormalities of the intestine and colon which are associated with the symptoms frequently encountered in patients with DM such as diarrhea and constipation. In this review, firstly we review DM-induced histomorphological and biomechanical remodeling of intestine and colon. Secondly we review motor-sensory dysfunction and how they relate to intestinal and colonic abnormalities. Finally the clinical consequences of DM-induced changes in the intestine and colon including diarrhea, constipation, gut microbiota change and colon cancer are discussed. The final goal is to increase the understanding of DM-induced changes in the gut and the subsequent clinical consequences in order to provide the clinicians with a better understanding of the GI disorders in diabetic patients and facilitates treatments tailored to these patients.

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“…Po svojim patohistološkim karakteristikama nalikuje drugim tumorima iz skupine mezenhimalnih tumora (lejomiom, lejomiosarkom, švanom, sinovijalni sarkom) pa je imunohistokemija neophodna za postavljanje dijagnoze 6 . GIST kao mezenhimalni tumor nastaje iz intersticijskih Cajalovih stanica 4,5,7 . Te su intersticijske stanice međusobno umrežene i umetnute između stanica glatkog mišićja GIT-a s kojima tvore dodir na mjesta slična sinapsama.…”

Section: Uvodunclassified

Review of gastrointestinal stromal tumors and contribution of dog1 immunohistochemical marker in diagnostics: A single tertiary centerb experience

et al. 2017

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Sažetak. Cilj: Prikazati patohistološko dijagnostičko iskustvo Kliničkog bolničkog centra (KBC)Rijeka u pacijenata s gastrointestinalnim stromalnim tumorom (GIST) dijagnosticiranim u razdoblju od 10 godina te pružiti pregled temeljnih karakteristika ovog mezenhimalnog tumora. Cilj je bio i prikazati osjetljivost DOG1 markera (engl. Discovered on GIST) te ga usporediti s osjetljivošću CD117 i vimentina. Materijali i metode: Iz baze podataka Zavoda za patologiju od 2005. do 2015. godine prikupljeni su podaci o 89 pacijenata s dijagnozom GIST-a. Podaci koje smo statistički analizirali obuhvaćali su dob, spol, lokalizaciju tumora, vrstu stanica (vretenaste ili epiteloidne), imunohistokemijske karakteristike te veličinu i mitotički indeks kao dva najvažnija parametra za određivanje prognostičke skupine. Rezultati: Medijan dobi iznosio je 64 godine, s rasponom od 17 do 93 godine. Značajna razlika u incidenciji među spolovima nije pronađena. Najčešća lokalizacija bio je želudac s postotkom od 48,3 %. Vretenastu morfologiju imalo je 84,3 % tumora, epiteloidnu 3.4 %, a miješanu (epiteloidno-vretenastu) 12,3 %. Podjelom GIST-ova u prognostičke skupine ustanovili smo da je 65,2 % tumora bilo benigno, 33,7 % maligno, a 1,1 % imalo je nesigurni maligni potencijal. Na uzorku od 25 tumora određivali smo osjetljivost imunohistokemijskih markera i dobili sljedeće rezultate: DOG1 imao je osjetljivost 100 %, CD117 88 %, a vimentin 60 %. Zaključci: DOG1 najosjetljiviji je imunohistokemijski marker korišten za GIST. Njegovo uvođenje u rutinsku imunohistokemijsku analizu pružilo je snažan doprinos u postavljanju dijagnoze. Prikazano iskustvo našeg centra moglo bi pružiti doprinos u napredovanju patološkodijagnostičke obrade GIST-ova na razini Republike Hrvatske.Ključne riječi: CD117 antigen; DOG1; gastrointestinalni stromalni tumori; imunohistokemija Abstract. Aim: To present the experience of Clinical Hospital Center (CHC) Rijeka, Department of Pathology in diagnosing gastrointestinal stromal tumors (GIST) in a 10-year period and to demonstrate consequential characteristics of this mesenchymal tumor. Also the aim was to present the sensitivity of DOG1 (Discovered on GIST) immunohistochemical marker, and to compare it with CD117 and vimentin results. Materials and methods: Searching the Pathology Department database, 89 GISTs were found in the period from 2005 to 2015. Epidemiologic and clinicopathological data: age, gender, dimension, localization, immunohistochemical charachteristics, also mitotic rate and malignant potential as two most important parameters for prognostic group estimation, were statistically analyzed. Results: Median age was 64, range from 17 to 93. 48.3 % of patients were male and 51.7 % were female. Most GISTs (48.3 %) were localized in stomach. Spindle cell morphology was present in 84.3 % GISTs, epitheloid in 3.4 % and mixed in 12.3 % tumors. According to the prognostic groups, malignant potential was assigned. The biggest portion, 65.2 % of tumors, were benign. Malignant potential was present

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Interstitial cells of Cajal — systematic review

Abstract: This paper reviews the distribution of interstitial cells of Cajal (ICC) (Folia Morphol 2016, 75, 3: 281-286)

Cited by 39 publications

References 66 publications

Acute Cholecystitis Reduces Interstitial Cells of Cajal in Porcine Gallbladder Through Decreased mRNA Synthesis

Acute Cholecystitis Reduces Interstitial Cells of Cajal in Porcine Gallbladder Through Decreased mRNA Synthesis

Diabetes-induced mechanophysiological changes in the small intestine and colon

Review of gastrointestinal stromal tumors and contribution of dog1 immunohistochemical marker in diagnostics: A single tertiary centerb experience

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