Interstitial-Cell Tumor of the Testis: Report of Two Cases

Ward, John A.; Krantz, Simon; Mendeloff, Joseph; Haltiwanger, Earl

doi:10.1210/jcem-20-12-1622

Cited by 38 publications

(2 citation statements)

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“…The 17-KS excretion ranged from 20 to 1,000 mg daily in four reported cases (1,4,5,7) and in our case, and it was thus within the range usually found with adrenocortical carcinoma (34). Although the steroid biosynthetic activity of the interstitial cell tumor was not suppressed by exogenous androgen as is the normal interstitial cell (35), the response to HCG demonstrated that the tumor was not completely autonomous.…”

Section: Discussionsupporting

confidence: 75%

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Metabolism of testoterone and related steroids in metastatic interstitial cell carcinoma of the testis.

Lipsett¹,

Sarfaty²,

Wilson³

et al. 1966

J. Clin. Invest.

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Interstitial cell carcinoma of the testis is a singularly rare steroid-producing cancer. Of the seven reported cases (1-7), urinary 17-ketosteroid (17-KS) excretion was high in the four cases in which it was measured. Abelson, Bulaschenko, Trommer, and Valdes-Dapena (7) fractionated the urinary 17-ketosteriods and corticoids in one recently reported case. There is, however, no comprehensive study of either the production of androgens or related steroids by this tumor. (testosterone) ; 17a-hydroxy-androst-4-en-3-one (epitestosterone); 3a-hydroxy-5,B-androstan-17-one (etiocholanolone); 3a-hydroxy-5a-androstan-17-one (androsterone); 3a,11,8-dihydroxy-51-androstan-3-one (11-hydroxyetiocholanolone); 3a-hydroxy-58-androstan-3,11-dione (ll-ketoetiocholanolone) ; 3a,11'B-dihydroxy-Sa-androstan-17-one (1l-hydroxy-androsterone); 3,B-hydroxy-androst-5-en-3-one (dehydroepiandrosterone, DHA); androst-4,en-3,17-dione (androstenedione); 3fi,16a-dihydroxy-5-androstan-17-one (16-hydroxy DHA); androst-5-en-3,8,17P-diol (androstenediol); pregn-5-en-3p8,20a-diol (pregnenediol); pregn-5-en-3fi,17a,20a-triol (pregnenetriol) ; 5,6-pregnan3a,20a-diol (pregnanediol); 5P-pregnan-3a,17a,20a-triol (pregnanetriol); 3a,17a-dihydroxy-5p8-pregnan-20-one (17-hydroxypregnanolone); 3a,17a,20a-trihydroxy-59-pregnan-l1-one (11-ketopregnanetriol); 5a-androst-16-en- 3,20-dione (cortisol) ; 3ac,11P,17a,21 -tetrahydroxy-5#9-pregnan-20-one (tetrahydrocortisol); 3a,17a,21-trihydroxy-5fi-pregnan-11,20-dione (tetrahydrocortisone) ; 3a, 11P,17a,21-tetrahydroxy-5a-pregnan-20-one (allotetrahydrocortisol) ; 3a,17a,21 -trihydroxy-5Sf-pregnan-20-one (tetrahydro substance S); 3-hydroxyestratrien-1,3,5 (10)-17-one (estrone); 1,3,5 (10-estratriene-3,17P-diol (estradiol); 1,3,5 (10)-estratriene-3,16a,17P-triol (estriol). 1700

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Section: Discussionsupporting

confidence: 75%

“…The average excretion of estrone was 75 ,ug per 24 hours; estriol, 29 ,ug per 24 hours; and estradiol, less than 13 ,ug per 24 hours. Other patients with interstitial cell carcinoma have had an increased excretion of estrogens determined either by bioassay (4, 7) or chemically (5).…”

mentioning

confidence: 99%

Metabolism of testoterone and related steroids in metastatic interstitial cell carcinoma of the testis.

Lipsett¹,

Sarfaty²,

Wilson³

et al. 1966

J. Clin. Invest.

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Malignant interstitial cell tumor of the testis

Tamoney

Noriega

1969

Cancer

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A case of malignant interstitial cell tumor of the testis in man and a review of the literature is presented. This is a rare steroid‐producing tumor; a careful search revealed only 9 published cases. The inadequacy of radiotherapy in management of the disease is dramatically demonstrated. (Periaortic nodes containing metastatic cancer were identified in retroperitoneal areas previously exposed to intensive cobalt therapy.) This lack of radiosensitivity leads to a plea for the use of a radical surgical attack as initial therapy. Illustrations of the comfortable and extensive exposure for a retroperitoneal node dissection using the Nagamatsu approach and technique are presented. Particular interest is aroused by this tumor because its endocrine activity so closely resembles that of cancer of the adrenal cortex. The hormonal disturbances such as gynecomastia and elevated testosterone levels are discussed, as well as the use of OP1‐DDD as a chemotherapeutic agent.

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Malignant interstitial cell testicular tumor

Mahon

Gosset

Trinity

et al. 1973

Cancer

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The 13th case of malignant interstitial cell tumor of the testicle is reported, and review of the literature made. Six cases of malignant interstitial cell tumor were associated with hydroceles. Absence of urinary chorionic gonadotropin levels does not indicate a more favorable prognosis. The average age at discovery of malignant interstitial cell tumor is 60 years. Retroperitoneal lymph nodes, lung, liver, and bones are the most frequent sites of metastatic involvement. The best treatment appears to be radical orchiectomy and surgical resection of metastases. Chemotherapy may offer remission when surgical resection of metastases is not possible.

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Interstitial-Cell Tumor of the Testis: Report of Two Cases

Cited by 38 publications

References 0 publications

Metabolism of testoterone and related steroids in metastatic interstitial cell carcinoma of the testis.

Metabolism of testoterone and related steroids in metastatic interstitial cell carcinoma of the testis.

Malignant interstitial cell tumor of the testis

Malignant interstitial cell testicular tumor

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