Interstitial ablative techniques for hepatic tumours

Erce, Cristina; Parks, Rowan W.

doi:10.1002/bjs.4091

Cited by 88 publications

(41 citation statements)

References 172 publications

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“…In situ tumour destruction with cryo, radiofrequency or laser ablation has received increasing attention as a treatment modality for focal cancer (Ruers et al, 2001;Ruers and Bleichrodt, 2002;Curley, 2003;Erce and Parks, 2003;Veth et al, 2005). However, little is known regarding the induction of immune responses after in situ tumour destruction or the fate of the generated tumour debris.…”

Section: Discussionmentioning

confidence: 99%

Efficient loading of dendritic cells following cryo and radiofrequency ablation in combination with immune modulation induces anti-tumour immunity

et al. 2006

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Dendritic cells (DC) are professional antigen-presenting cells that play a pivotal role in the induction of immunity. Ex vivo-generated, tumour antigen-loaded mature DC are currently exploited as cancer vaccines in clinical studies. However, antigen loading and maturation of DC directly in vivo would greatly facilitate the application of DC-based vaccines. We formerly showed in murine models that radiofrequency-mediated tumour destruction can provide an antigen source for the in vivo induction of anti-tumour immunity, and we explored the role of DC herein. In this paper we evaluate radiofrequency and cryo ablation for their ability to provide an antigen source for DC and compare this with an ex vivo-loaded DC vaccine. The data obtained with model antigens demonstrate that upon tumour destruction by radiofrequency ablation, up to 7% of the total draining lymph node (LN) DC contained antigen, whereas only few DC from the conventional vaccine reached the LN. Interestingly, following cryo ablation the amount of antigen-loaded DC is almost doubled. Analysis of surface markers revealed that both destruction methods were able to induce DC maturation. Finally, we show that in situ tumour ablation can be efficiently combined with immune modulation by anti-CTLA-4 antibodies or regulatory Tcell depletion. These combination treatments protected mice from the outgrowth of tumour challenges, and led to in vivo enhancement of tumour-specific T-cell numbers, which produced more IFN-g upon activation. Therefore, in situ tumour destruction in combination with immune modulation creates a unique, 'in situ DC-vaccine' that is readily applicable in the clinic without prior knowledge of tumour antigens.

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Section: Discussionmentioning

confidence: 99%

Efficient loading of dendritic cells following cryo and radiofrequency ablation in combination with immune modulation induces anti-tumour immunity

et al. 2006

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“…The SAR [W/kg] in tissue is calculated as a function of position as follows: (2) where is the tissue conductivity [S/m] at the excitation frequency, is the tissue density , and is the spatially dependent time-harmonic electric field vector [V/m]. 3 shows the SAR pattern, normalized to the maximum value in the simulation region, in dB.…”

Section: A the Computational Electromagnetics (Cem) Modelmentioning

confidence: 99%

A Floating Sleeve Antenna Yields Localized Hepatic Microwave Ablation

Yang

Bertram

Converse

et al. 2006

IEEE Trans. Biomed. Eng.

150

114

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Abstract-We report a novel coaxial antenna for hepatic microwave ablation. This device uses a floating sleeve, that is, a metal conductor electrically isolated from the outer connector of the antenna coaxial body, to achieve a highly localized specific absorption rate pattern that is independent of insertion depth. This floating sleeve coaxial dipole antenna has low power reflection in the 2.4-GHz IMS band. Ex vivo experiments confirm our numerical simulation results.

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“…Ablative therapies have gained a role in the management of patients with complex disease [87,88]. If the full extent of disease is not resectable in a single sitting due to anatomical constraints or a threat to the FLR, then ablation in combination with resection may be utilised.…”

Section: Operative Approachmentioning

confidence: 99%

Surgery for Colorectal Liver Metastases

McNally

Parks²

2013

Dig Surg

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Half of all patients with colorectal cancer develop metastatic disease. The liver is the principal site for metastases, and surgical resection is the only modality that offers the potential for long-term cure. Appropriate patient selection for surgery and improvements in perioperative care have resulted in low morbidity and mortality rates, resulting in this being the therapy of choice for suitable patients. Modern management of colorectal liver metastases is multimodal incorporating open and laparoscopic surgery, ablative therapies such as radiofrequency ablation or microwave ablation and (neo)adjuvant chemotherapy. The majority of patients with hepatic metastases should be considered for resectional surgery, if all disease can be resected, as this offers the only opportunity for prolonged survival.

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Interstitial ablative techniques for hepatic tumours

Abstract: Although surgical resection remains the first line of treatment for selected patients with primary and secondary liver malignancies, interstitial ablative techniques are promising therapies for patients not suitable for hepatic resection or as an adjunct to liver surgery.

Cited by 88 publications

References 172 publications

Efficient loading of dendritic cells following cryo and radiofrequency ablation in combination with immune modulation induces anti-tumour immunity

Efficient loading of dendritic cells following cryo and radiofrequency ablation in combination with immune modulation induces anti-tumour immunity

A Floating Sleeve Antenna Yields Localized Hepatic Microwave Ablation

Surgery for Colorectal Liver Metastases

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