Interrelationships between tuberculosis and chronic obstructive pulmonary disease

Zavala, Michael; Becker, Greta L.; Blount, Robert J.

doi:10.1097/mcp.0000000000000938

Cited by 3 publications

(1 citation statement)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous observational studies have shown a strong association between COPD and TB, suggesting that both may be risk factors for each other [9,13,29,30]. Furthermore, in ammation and damage to the respiratory system caused by COPD can promote the infection of TB, and respiratory infections and in ammation may also play a role in the development and progression of COPD [31] [32].…”

Section: Discussionmentioning

confidence: 99%

Causal relationship between chronic obstructive pulmonary disease and respiratory tuberculosis susceptibility: A two-sample Bayesian weighted Mendelian randomization study

Aili,

Zhang,

Wang

et al. 2024

Preprint

View full text Add to dashboard Cite

Background The causal relationship between COPD and respiratory TB is still unclear due to limited evidence from prospective studies. Therefore, the present study aimed to assess the causal relationship between COPD and respiratory TB using this two-sample Bayesian weighted Mendelian randomization (BWMR) study. Methods The genetic instrumental variants (IVs) for COPD and respiratory TB were obtained from the IEU Open GWAS project in 2021. The inverse variance weighted (IWV) method was used as the main statistical analysis method and was supplemented with weighted median and BWMR methods. Pleiotropy was tested using the MR-PRESSO global test and MR-Egger regression. Heterogeneity was analyzed using Cochran's Q statistics. The robustness of the results was tested using the leave-one-out sensitivity analysis method. Results In our two-sample BWMR analysis, we found that patients with COPD had a higher risk of respiratory TB based on IVW (OR = 1.259, 95% CI for OR: 1.011–1.568; p = 0.040), weighted median (OR = 1.287, 95% CI for OR: 0.981–1.688; p = 0 .069) and BWMR (OR = 1.240, 95% CI for OR: 1.013–1.518; p = 0.037). Reverse BWMR analysis showed that respiratory TB has no causal effect on COPD. We found no significant pleiotropy or heterogeneity in all selected IVs. The results were stable when removing the SNPs one by one. Conclusion This two-sample BWMR study provided compelling evidence that individuals with COPD are at a higher risk of respiratory TB at the genetic level, while respiratory TB has no causal effect on COPD.

show abstract

Section: Discussionmentioning

confidence: 99%

Causal relationship between chronic obstructive pulmonary disease and respiratory tuberculosis susceptibility: A two-sample Bayesian weighted Mendelian randomization study

Aili,

Zhang,

Wang

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Factors affecting the readiness for hospital discharge of initially treated pulmonary tuberculosis patients in China: a phenomenological study

Wang,

Zhang,

Rao

et al. 2024

BMC Public Health

View full text Add to dashboard Cite

Evaluation of the effects of curcumin on chronic obstructive pulmonary disease with a bio-computational approach

Maboudian,

Amjad,

Asnaashari

et al. 2024

Egypt J Med Hum Genet

View full text Add to dashboard Cite

Background According to the increasing trend of COPD, the timely diagnosis and treatment of the disease can reduce the high costs to the health systems. Therefore, by biological calculation methods, signaling pathways and genes involved in this disease can be obtained and used to design drugs and other treatment methods. By using biological calculations, we determined that curcumin can affect this disease and its genes and signaling pathways. Our goal in this study was to find the genes by which curcumin exerts its effect and can maintain the function of corticosteroids against oxidizing agents. Results By finding the genes, it is possible to find precisely the pathways by which curcumin works, which can be used to design other drugs that cause these pathways and minimize their side effects. This study considers healthy samples (with/without curcumin) and oxygen-free radicals (with/without curcumin). Finally, statistical algorithms extract meaningful genes as effective biomarkers to investigate curcumin's effects and signaling pathways in COPD. The results show that the genes finally obtained as the most critical genes confirmed by the literature are effective in COPD. Finally, curcumin was input in SwissTargetPrediction to identify potential protein receptors. We used LigPlot+ software to visualize the receptor–ligand binding result provided by iGEMDOCK. Conclusions The data showed that the most significant genes in each group have been confirmed in other studies to be effective in this disease, and protein–protein interaction networks can be established between them to investigate their roles.

show abstract

Interrelationships between tuberculosis and chronic obstructive pulmonary disease

Cited by 3 publications

References 97 publications

Causal relationship between chronic obstructive pulmonary disease and respiratory tuberculosis susceptibility: A two-sample Bayesian weighted Mendelian randomization study

Causal relationship between chronic obstructive pulmonary disease and respiratory tuberculosis susceptibility: A two-sample Bayesian weighted Mendelian randomization study

Factors affecting the readiness for hospital discharge of initially treated pulmonary tuberculosis patients in China: a phenomenological study

Evaluation of the effects of curcumin on chronic obstructive pulmonary disease with a bio-computational approach

Contact Info

Product

Resources

About