Interrelationship of antioxidative status, lipid peroxidation, and lipid profile in insulin-dependent and non-insulin-dependent diabetic patients

Cimbaljević, Branko; Vasilijević, Ana; Cimbaljevic, Slavica; Buzadžić, Biljana; Korać, Aleksandra; Petrović, Vesna; Janković, Aleksandra; Korać, Bato

doi:10.1139/y07-088

Cited by 16 publications

(9 citation statements)

References 48 publications

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“…It has been shown in various studies that diabetes mellitus is associated with increased formation of free radicals, and heavy oxidative stress [3]. This is supported by data showing that supplementation with nonenzymatic antioxidants, such as vitamin E and vitamin C, diminished diabetes-induced increase in lipid peroxidation (MDA) in many rat tissues, including kidney, liver, and muscles, as well as in plasma and erythrocytes [40,41]. Furthermore, a reduction in action of GSH level, GSH-Px, SOD, and CAT, involved in the detoxification of H 2 O 2 , has been observed in diabetic rats and humans [41].…”

Section: Discussionmentioning

confidence: 91%

17β-Estradiol and Vitamin E Modulates Oxidative Stress-Induced Kidney Toxicity in Diabetic Ovariectomized Rat

Ulaş

Çay

2011

Biol Trace Elem Res

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The aim of this study was to investigate the effects of vitamin E (alpha-tocopherol) and 17β-estradiol (E(2)) supplementation on malondialdehyde (MDA), glutathione (GSH), vitamin A, beta carotene, selenium-dependent glutathione peroxidase (GSH-Px), zinc-dependent superoxide dismutase (SOD), and copper/zinc-dependent catalase (CAT) values in the kidney of ovariectomized (OVX) diabetic rats. Forty-two female rats were randomly divided into seven equal groups as follows: group I, control; group II, OVX; group III, OVX+E(2); group IV, OVX+E(2)+alpha-tocopherol; group V, OVX+diabetic; group VI, OVX+diabetic+E(2); and group VII, OVX+diabetic+E(2)+alpha-tocopherol. E(2) (40 μg kg(-1)/day) and alpha-tocopherol (100 μg kg(-1)/day) were given. Bilateral ovariectomy was performed in all groups except group I. After 4 weeks, antioxidant and MDA levels in the kidney for all groups were analyzed. GSH-Px, CAT, SOD, GSH levels, vitamin A, and beta carotene levels were decreased in OVX group compared to those in the control group but MDA level was elevated via ovariectomy. However, E(2) and E(2)+alpha-tocopherol supplementations in OVX group was associated with an increase in the GSH-Px, GSH, CAT and Zn-SOD values, vitamin A, and beta carotene levels but a decrease in MDA levels in kidney. The MDA levels in the kidney of diabetic OVX rats were found higher than those in the control and OVX groups. However, GSH, GSH-Px, CAT, SOD, vitamin A, and beta carotene levels in kidney were lower in OVX diabetic rats. On the other hand, E(2) and E(2)+alpha-tocopherol supplementations to OVX diabetic rats have caused an increase in GSH-Px, CAT and SOD, GSH, vitamin A, and beta carotene levels but a decrease in MDA levels. In conclusion, the E(2) and E(2)+alpha-tocopherol supplementations to diabetic OVX and OVX rats may strengthen the antioxidant defense system by reducing lipid peroxidation, and therefore they may play a role in preventing renal disorders.

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Section: Discussionmentioning

confidence: 91%

17β-Estradiol and Vitamin E Modulates Oxidative Stress-Induced Kidney Toxicity in Diabetic Ovariectomized Rat

Ulaş

Çay

2011

Biol Trace Elem Res

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“…In contrast to the findings of this study, there are reports that have identified an increased SOD level in human diabetics, highlighting the complex interplay of patient, disease, and the multitude of parameters that combine to result in oxidative stress. 20 Consumption of Purina DM diet for 8 weeks resulted in a significant increase in GPx activity in both diabetic and control cats. One potential explanation for the apparent effect of diet on GPx levels would be the presence of selenium in the diet used in this study.…”

Section: Discussionmentioning

confidence: 94%

Oxidative stress and innate immunity in feline patients with diabetes mellitus: The role of nutrition

Webb

Falkowski

2009

Journal of Feline Medicine and Surgery

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This study was undertaken to test the hypothesis that oxidative stress is increased and neutrophil function is decreased in cats with diabetes mellitus (DM). Measures of oxidative stress and neutrophil function were evaluated in 20 control and 15 diabetic cats. Cats were then fed a diet designed specifically for feline diabetics (Purina DM Dietetic Management Feline Formula) for 8 weeks, after which all assays were repeated. Cats with DM had significantly less plasma superoxide dismutase (SOD) than control cats, consistent with a greater degree of oxidative stress in the DM group. Following 8 weeks of consuming a diabetes-specific diet glutathione peroxidase, an antioxidant enzyme increased significantly in both groups. Other parameters of oxidative stress, as well as neutrophil function, were similar between groups and did not change following dietary intervention. The DM cats were significantly older and heavier than the control cats, which may have contributed to differences in parameters of oxidative stress and levels of antioxidant enzymes between these groups, but the decreased level of SOD enzyme in the diabetic group would appear to support the continued development of targeted antioxidant supplementation for this cats with this disease.

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“…Constant exposure to free radicals and high oxidative stress in diabetes have also been associated with erythrocyte structural damage. [ 18 ] Lipid peroxidation alters the cellular structure of membrane-bound enzymes by changing phospholipids and fatty acid composition. Previous studies have reported reduced erythrocyte ATPase activity, specifically the Na + /K + ATPase in insulin-deficient conditions.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress parameters and erythrocyte membrane adenosine triphosphatase activities in streptozotocin-induced diabetic rats administered aqueous preparation ofKalanchoe Pinnataleaves

2016

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Background:Diabetes mellitus is a chronic metabolic disease that according to the World Health Organization affects more than 382 million people. The rise in diabetes mellitus coupled with the lack of an effective treatment has led many to investigate medicinal plants to identify a viable alternative.Objective:To evaluate red blood cell (RBC) membrane adenosine triphosphatase (ATPase) activities and antioxidant levels in streptozotocin-induced diabetic rats administered aqueous preparation of Kalanchoe pinnata leaves.Materials and Methods:Diabetes mellitus was induced in rats by a single administration of streptozotocin (60 mg/kg). Diabetic rats were then treated with aqueous K. pinnata preparation (three mature leaves ~ 9.96 g/70 kg body weight or about 0.14 g/kg body weight/day) for 30 days. Serum glucose, RBC membrane ATPase activities, and antioxidant levels were determined.Results:We noted weight loss and reduced food consumption in the treated diabetic group. Serum glucose levels were reduced in the treated diabetic group compared to the other groups. Superoxide dismutase activity and glutathione levels were not significantly elevated in the treated group compared to the diabetic group. However, serum catalase activity was significantly (P < 0.05) increased in the treated diabetic group compared to the other groups. Serum thiobarbituric acid reactive substances were not significantly altered among the groups. There was a significant (P < 0.05) increase in Mg2+ ATPase activity and a nonsignificant increase in Na+/K+ ATPase activity in the RBC membrane of the treated diabetic group compared to the diabetic group.Conclusion:The consumption of aqueous preparation of K. pinnata may accrue benefits in the management of diabetes by lowering oxidative stress often associated with the disease and improving the availability of cellular magnesium through an increase in the magnesium ATPase pump in the RBC membrane for increased cellular metabolism of glucose through the glycolytic pathway.SUMMARY We noted weight loss and reduced food consumption in the diabetic rats treated with K. pinnata preparationSerum glucose levels were reduced in diabetic rats treated with K. pinnata preparationSerum catalase activity was significantly (P < 0.05) increased in diabetic rats treated with K. pinnata preparationWe also noted a significant (P < 0.05) increase in Mg2+ ATPase activity in the RBC membranes of diabetic rats treated with K. pinnata preparationOverall, the consumption of aqueous preparation of K. pinnata lowered oxidative stress often associated with diabetes and improved availability of cellular magnesium through an increase in magnesium ATPase pump in the RBC membrane.

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Interrelationship of antioxidative status, lipid peroxidation, and lipid profile in insulin-dependent and non-insulin-dependent diabetic patients

Cited by 16 publications

References 48 publications

17β-Estradiol and Vitamin E Modulates Oxidative Stress-Induced Kidney Toxicity in Diabetic Ovariectomized Rat

17β-Estradiol and Vitamin E Modulates Oxidative Stress-Induced Kidney Toxicity in Diabetic Ovariectomized Rat

Oxidative stress and innate immunity in feline patients with diabetes mellitus: The role of nutrition

Oxidative stress parameters and erythrocyte membrane adenosine triphosphatase activities in streptozotocin-induced diabetic rats administered aqueous preparation ofKalanchoe Pinnataleaves

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