Interrelationship between Plasma Luteinizing Hormone and Oestradiol in the Human Menstrual Cycle

Cs, Corker; Naftolin, Frederick; Exley, D.

doi:10.1038/2221063a0

Cited by 41 publications

(15 citation statements)

References 3 publications

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“…1, 3, and 4, were not different from those described by others for women in this age group (2)(3)(4)(5)(6)(7)(8)(9). In each instance FSH, AY.…”

Section: Resultssupporting

confidence: 42%

“…Analysis of hormonal regulation of the human menstrual cycle by measurement of circulating pituitary and ovarian hormones has, to date, been limited to young women with regular cycle (2)(3)(4)(5)(6)(7)(8)(9)(10) or to clinically abnormal cycles (11)(12)(13)(14)(15)(16)(17). We have measured serum levels of serum luteinizing hormone (LH),1 folliclestimulating hormone (FSH), estradiol (E2), and progesterone (P), throughout the cycles of women at the extremes of menstrual experience and compared the findings with those in young and middle-aged normal women and in certain menstrual disorders previously reported (16,17).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hormonal characteristics of the human menstrual cycle throughout reproductive life.

Sherman¹,

Korenman²

1975

J. Clin. Invest.

529

158

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A B S T R A C T The changes in serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, and progesterone that occur both early and late in reproductive life were characterized and compared with findings in young, normal women and in patients with certain menstrual disorders.A total of 50 complete menstrual cycles in 37 women were examined. Five distinct patterns of hormonal regulation were found, three of which are reported here: (a) A long follicular phase and delayed follicular maturation in young women with long, unpredictable intermenstrual intervals from menarche; (b) a short follicular phase with increasing age and in short cycles in perimenopausal women; and (c) true anovulatory vaginal bleeding in long cycles in perimenopausal women.The short cycles before and during the menopausal transition were found to have lower E2 levels and high FSH concentrations throughout, while LH remained in the normal range. During long cycles in perimenopausal women, concentrations of LH and FSH were in the menopausal range. However, follicular maturation was observed months after high levels of gonadotropins were attained.These studies permit the characterization of the menstrual history of the normal woman in terms of the hormonal changes that occur and provide a basis for the definition of several disorders of follicular maturation.

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“…1, 3, and 4, were not different from those described by others for women in this age group (2)(3)(4)(5)(6)(7)(8)(9). In each instance FSH, AY.…”

Section: Resultssupporting

confidence: 42%

Section: Introductionmentioning

confidence: 99%

Hormonal characteristics of the human menstrual cycle throughout reproductive life.

Sherman¹,

Korenman²

1975

J. Clin. Invest.

529

158

View full text Add to dashboard Cite

show abstract

“…Failure of augmentation of pituitary responsiveness by estrogen in vitro may be due to an insufficient duration of exposure of the pituitary to estrogen. The rise of plasma estrogen is known to precede the preovulatory peak in plasma LH and FSH in rats (29), monkeys (30), and women (31). This "positive feedback" may sensitize the pituitary to LH-RH.…”

Section: Discussionmentioning

confidence: 99%

Effect of Sex Steroids on Pituitary Responses to LH- and FSH-Releasing Hormone In Vitro*

1973

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The effects of 173-estradiol (E), ethinylestradiol (EE), progesterone (P), 5a-dihydroprogesterone (5DHP), 17a-hydroxyprogesterone (17HP), testosterone (T), dihydrotestosterone (DHT) and combinations of P, 5DHP, 17HP with E on the basal release of LH and FSH, as well on the pituitary responses to synthetic LH and FSH-releasing hormone (LH-RH/ FSH-RH), were examined in vitro using isolated rat pituitaries. EE in doses of O.OOO16-O.5 Mg/ml suppressed release of LH and FSH in response to LH-RH. E in doses of 0.036-0.08 M-g/ml augmented the basal level of LH in the medium and rarely that of FSH, but inhibited the release of FSH in response to LH-RH. Stimulation of LH release induced by LH-RH was not potentiated by the smaller doses of estrogens. E in doses of 0.5-25 M

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“…Recent studies on plasma oestradiol and lh levels have supported the growing view that a rise in the circulating oestrogen levels may provide the stimulus for pituitary lh release and subsequent ovulation (Catt, 1969;Corker, Naftolin & Exley, 1969). Further evidence that plasma oestradiol is the physiological trigger for the mid-cycle peak of lh has been provided by Vande Wiele, Bogumil, Dyrenfurth, Ferin, Jewelewicz, Warren, Rizkallah & Mikhail (1970) and by Dufau, Catt, Dulmanis, Fullerton, Hudson & Burger (1970 75, 135 and 150 nih units, respectively).…”

mentioning

confidence: 91%

Release of Lh During Treatment With Purified Sheep FSH Without Signs of Adequate Follicular Maturation in Women

Pujol-Amat¹,

Corker²,

Mackinnon³

et al. 1972

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Interrelationship between Plasma Luteinizing Hormone and Oestradiol in the Human Menstrual Cycle

Cited by 41 publications

References 3 publications

Hormonal characteristics of the human menstrual cycle throughout reproductive life.

Hormonal characteristics of the human menstrual cycle throughout reproductive life.

Effect of Sex Steroids on Pituitary Responses to LH- and FSH-Releasing Hormone In Vitro*

Release of Lh During Treatment With Purified Sheep FSH Without Signs of Adequate Follicular Maturation in Women

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