Interrelation of Biological Rhythms and Circadian Hormones Producement and Their Impact on Medicine Usage

Vasko, Maryna Y.; Tkachenko, Iryna; Pavlenkova, Olena V.; Pysarenko, Oleg A.

doi:10.36740/wlek202108133

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…Vasko et al and the authors investigated that there is a relationship between human biological rhythms and the production of circadian hormones. This study made it possible to reduce the dosage of the prescribed drugs and increase the effectiveness of the treatment in compliance with the principles of chronotherapy [26].…”

Section: Discussionmentioning

confidence: 99%

The Role of Chronotype of Patients and Cryoexrtact of Placenta in the Activity of Antioxidant Enzymes in Facial Scar

Toropov¹,

Локес²,

Faustova³

et al. 2023

Open Access Maced J Med Sci

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BACKGROUND: The chronotypical features of people have a significant impact on the course of reparative processes in the patient’s body. Understanding the mechanisms of influence on the course of reparative skin regeneration after planned surgical interventions within the maxillofacial tissues can contribute to improving the provision of medical care to such patients. AIM: The study was aimed to determine role of chronotype of patients and cryoexrtact of placenta in the activity of antioxidant enzymes in facial scar. METHODS: In our study, 60 patients (36 males and 24 females) of the Department of Maxillofacial Surgery of the Poltava Regional Clinical Hospital, Ukraine, aged from 18 to 68 years, who underwent inpatient treatment for planned surgical interventions of the maxillofacial area, were enrolled. At the time of the study, the patients did not have concomitant diseases, but if necessary, all patients could consult by other specialists. The practical section was carried out between September 2019 and August 2021 as follow. According to our study, 60 patients were divided depending on the type of chronotype, which was determined by the Horn-Ostberg questionnaire in Stepanova’s modification and the type of using treatment taking into account different ways of using of cryoextract of placenta. The activities of superoxide dismutase and catalase were determined on the 90th, 180th, and 360th days of observation in the forming scar tissue. We used the method of Chevari et al. to determine the activity of superoxide dismutase. Catalase activity in homogenates of scar tissue was determined according to the method of M.A. Koroliuk. RESULTS: It was noted that the enzymatic activity of catalase in the scar homogenate is characterized by a lower dynamics of changes than the activity of superoxide dismutase. Positive dynamics were noted under the conditions of use in the treatment protocol of placenta cryoextract, which was more pronounced in patients with a morning chronotype. CONCLUSIONS: The most significant changes were observed in the studied indicators of antioxidant protection in patients of the morning chronotype who underwent intrawound administration of cryoextract of the placenta in combination with electrophoresis of this remedy against the background of a standard treatment protocol, especially at earlier terms after surgical treatment.

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Section: Discussionmentioning

confidence: 99%

The Role of Chronotype of Patients and Cryoexrtact of Placenta in the Activity of Antioxidant Enzymes in Facial Scar

Toropov¹,

Локес²,

Faustova³

et al. 2023

Open Access Maced J Med Sci

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Chronobiological Aspects of Sleep Disorders Under Anxiety Disorders

Zhyvotovska

2023

Act. Probl. of the Modern Med.

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Modern research highlights the connection between the deterioration of sleep quality, sleep efficiency and daytime sleepiness with the disruption of the sleep-wake pattern due to circadian dysfunction. The aim of the study is to investigate the features of sleep disorders in patients with anxiety disorders of neurotic genesis, taking into account individual chronotype. 91 patients, 48 women (52,7%) and 43 men (47,3%) with anxiety disorders of neurotic origin were examined at Regional Center of Psychiatric Care. The Horn-Ostberg Morningness-Eveningness Questionnaire was used to determine the chronotype of participants. The study was also conducted using the Hamilton anxiety scale, Pittsburgh sleep quality questionnaire, Insomnia severity index, Epworth sleepiness scale, and Fatigue severity scale. All patients, depending on the individual chronotype, were divided into 3 groups, representative by age and gender. The morning type group comprised 32 patients (35.2%), the intermediate type group consisted of 31 patients (34.1%), and the evening type group included 28 patients (30.7%). A significant difference has been established between groups of morning and evening type in terms of the total score of anxiety and its somatic component (p<0.05). There is no difference in the indicator of the mental component of anxiety. However, this indicator is higher in people with extreme evening type compared to extreme morning type (p=0.001). Differences in indicators of sleep disturbances have been found to depend on the individual chronotype. Representatives of the evening type compared to the intermediate and morning types have significantly higher indicators of sleep latency and daytime dysfunction according to PSQI, as well as daytime sleepiness and fatigue severity (p<0.001). People with an intermediate chronotype have better sleep duration (p<0.05) and lower insomnia severity index than people with a morning (p<0.05) and evening type (p<0.01).

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Interrelation of Biological Rhythms and Circadian Hormones Producement and Their Impact on Medicine Usage

Cited by 2 publications

References 39 publications

The Role of Chronotype of Patients and Cryoexrtact of Placenta in the Activity of Antioxidant Enzymes in Facial Scar

The Role of Chronotype of Patients and Cryoexrtact of Placenta in the Activity of Antioxidant Enzymes in Facial Scar

Chronobiological Aspects of Sleep Disorders Under Anxiety Disorders

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