Interrater reliability for histopathologic diagnosis of keratinocyte carcinomas

Leader, Nicholas; Means, Alexander D.; Robinson‐Bostom, Leslie; Telang, Gladys H.; Wilkel, Caroline S.; Weinstock, Martin A.

doi:10.1016/j.jaad.2017.07.024

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…21 More recently, Jagdeo and colleagues 22 showed minimal concordance between 2 dermatopathologists in diagnosing well, moderately, and poorly differentiated cSCC in 47 specimens (k 5 0.25 overall, 0.23 for well, 0.20 for moderate, and unable to calculate for poor). Leader and colleagues 23 found a moderate to substantial intrarater concordance (k 5 0.79) among 3 dermatopathologists in diagnosing invasive SCC, but did not look at concordance among specific levels of differentiation.…”

Section: Discussionmentioning

confidence: 97%

Concordance of Squamous Cell Carcinoma Histologic Grading Among Dermatopathologists and Mohs Surgeons

Prezzano¹,

Scott

Smith³

et al. 2021

Dermatol Surg

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BACKGROUND Current staging systems for cutaneous squamous cell carcinoma (cSCC) incorporate histologic grade. There are no universally agreed on criteria to define differentiation for cSCC. OBJECTIVE To determine the interrater and intrarater reliability among dermatopathologists and Mohs surgeons in grading histological differentiation for cSCC. METHODS AND MATERIALS One hundred thirty-one archived slides were selected. Three dermatopathologists and 3 Mohs surgeons graded the tumors in a blinded manner (Round 1). In an attempt to improve concordance, all 6 participants were then asked to regrade the tumors based on a devised quantitative grading scale (Round 2). RESULTS For Round 1, overall κ was 0.56 corresponding to a weak agreement. κ for well, moderate, and poorly differentiated tumors was 0.68, 0.39, and 0.59, respectively, corresponding to moderate, minimal, and weak concordance. For Round 2 of the study, overall κ was 0.60, with κ = 0.75, 0.46, and 0.61 for well, moderate, and poorly differentiated tumors, respectively. Overall intrarater reliability was 0.70 (κ = 0.70, 0.77, 0.68, 0.71, 0.56, and 0.75), corresponding to a moderate concordance. CONCLUSION Overall concordance for cSCC histologic grading is weak to moderate among the experimental group. Substantial differences in concordance exist among histological degrees of differentiation, with lowest agreement in moderately differentiated tumors.

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Section: Discussionmentioning

confidence: 97%

Concordance of Squamous Cell Carcinoma Histologic Grading Among Dermatopathologists and Mohs Surgeons

Prezzano¹,

Scott

Smith³

et al. 2021

Dermatol Surg

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“…Meghan BEATSON [1][2][3] , Alexander D. MEANS 1,2,4 , Nicholas F. LEADER 1,2 , Leslie ROBINSON-BOSTOM a smaller number of SCCs in the 5-FU group vs. control group, but the reliability of either of these findings is uncertain given the multiple comparisons and small numbers (Table II). There were no differences between the 5-FU and control groups for mean age of development, mean size, and anatomic location of the tumor.…”

Section: Characteristics Of Keratinocyte Carcinomas and Patients Withmentioning

confidence: 99%

Characteristics of Keratinocyte Carcinomas and Patients with Keratinocyte Carcinomas Following a Single 2–4 Week Course of Topical 5-fluorouracil on the Face and Ears

Beatson¹,

Means²,

Leader³

et al. 2019

Acta Derm Venerol

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“…21 The inappropriate use of kappa statistics is not limited to CM or TCM, with recent examples occurring in other modalities. 18,[22][23][24][25][26] Furthermore, the use of kappa statistics may have contributed to the surprising result of training not improving diagnostic reliability that was reported in one paper. 25 No investigation of diagnostic reliability within open populations has been found in the CM literature; open population is defined here as a random sample of individuals taken from the general population with a full spectrum of health conditions.…”

Section: Introductionmentioning

confidence: 99%

Consensus in Traditional Chinese Medical Diagnosis in Open Populations

Popplewell¹,

Reizes

Zaslawski

2019

The Journal of Alternative and Complementary Medicine

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There appears to be very low diagnostic agreement between practitioners. This is an important finding. If unchallenged by further investigation, the recognition of such poor diagnostic consensus may lead to rejection of TCM theory before it has been adequately assessed. Diagnostic agreement must be improved so that future investigations into treatment effectiveness or mechanisms of action are made on a valid basis. Additionally, the current TCM diagnostic format must be altered to allow the application of chance-removed statistics or the calculation of a standard error with open populations. This article is the first of a series of three that report problems in TCM diagnostic reliability and proposes solutions to the issues outlined.

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Interrater reliability for histopathologic diagnosis of keratinocyte carcinomas

Cited by 5 publications

References 5 publications

Concordance of Squamous Cell Carcinoma Histologic Grading Among Dermatopathologists and Mohs Surgeons

Concordance of Squamous Cell Carcinoma Histologic Grading Among Dermatopathologists and Mohs Surgeons

Characteristics of Keratinocyte Carcinomas and Patients with Keratinocyte Carcinomas Following a Single 2–4 Week Course of Topical 5-fluorouracil on the Face and Ears

Consensus in Traditional Chinese Medical Diagnosis in Open Populations

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