“…The same group in another comparison study concluded, "For evaluation of symptomatic lower extremity ischemia, 2D TOF MRA cannot be considered a reliable substitute for x-ray angiography." 135 Other centers have demonstrated better success using similar techniques. Carpenter et al 135a performed a 2D TOF MRA and CA study in 47 patients and formulated separate interventional plans for each modality.…”
“…The same group in another comparison study concluded, "For evaluation of symptomatic lower extremity ischemia, 2D TOF MRA cannot be considered a reliable substitute for x-ray angiography." 135 Other centers have demonstrated better success using similar techniques. Carpenter et al 135a performed a 2D TOF MRA and CA study in 47 patients and formulated separate interventional plans for each modality.…”
“…RSNA, 2008 Supplemental material: http://radiology.rsnajnls.org/cgi /content/full/2491071706/DC1 C ontrast material-enhanced magnetic resonance (MR) angiography is an imaging technique with a multitude of clinical applications (1)(2)(3)(4). Currently, contrast-enhanced MR angiographic techniques are most commonly based on T1 shortening of blood caused by MR angiographic contrast agents (5,6).…”
Purpose:To evaluate the utility of inversion recovery with on-resonant water suppression (IRON) in combination with injection of the long-circulating monocrystalline iron oxide nanoparticle (MION)-47 for contrast material-enhanced magnetic resonance (MR) angiography.
Materials and Methods:Experiments were approved by the institutional animal care committee. Eleven rabbits were imaged at baseline before injection of a contrast agent and then serially 5-30 minutes, 2 hours, 1 day, and 3 days after a single intravenous bolus injection of 80 mol of MION-47 per kilogram of body weight (n ϭ 6) or 250 mol/kg MION-47 (n ϭ 5). Conventional T1-weighted MR angiography and IRON MR angiography were performed on a clinical 3.0-T imager. Signal-to-noise and contrast-to-noise ratios were measured in the aorta of rabbits in vivo. Venous blood was obtained from the rabbits before and after MION-47 injection for use in phantom studies.
Results:In vitro blood that contained MION-47 appeared signal attenuated on T1-weighted angiograms, while characteristic signal-enhanced dipolar fields were observed on IRON angiograms. In vivo, the vessel lumen was signal attenuated on T1-weighted MR angiograms after MION-47 injection, while IRON supported high intravascular contrast by simultaneously providing positive signal within the vessels and suppressing background tissue (mean contrast-tonoise ratio, 61.9 Ϯ 12.4 [standard deviation] after injection vs 1.1 Ϯ 0.4 at baseline, P Ͻ .001). Contrast-to-noise ratio was higher on IRON MR angiograms than on conventional T1-weighted MR angiograms (9.0 Ϯ 2.5, P Ͻ .001 vs IRON MR angiography) and persisted up to 24 hours after MION-47 injection (76.2 Ϯ 15.9, P Ͻ .001 vs baseline).
Conclusion:IRON MR angiography in conjunction with superparamagnetic nanoparticle administration provides high intravascular contrast over a long time and without the need for image subtraction.
“…One study evaluated 2D PC MRA, 66 11 evaluated 2D TOF MRA, 22,27,29,32,40,41,53,55,64,69,74 and 14 evaluated CE MRA. 9,28,36,46,49,51,53,61,65,67,68,70,73,76 There were no studies providing results for the assessment of 3D TOF MRA.…”
Section: Mramentioning
confidence: 99%
“…The 11 studies evaluating 2D TOF MRA 22,27,29,32,40,41,53,55,64,69,74 provided a total of 22 data sets. The results are reported by the anatomy assessed and the full set of diagnostic accuracy results is presented in Table 5.…”
Section: D Tof Mramentioning
confidence: 99%
“…22,40,41,64,74 The sensitivity of 2D TOF MRA ranged from 79% (specificity 89%) to 94% (specificity 92%). The specificity ranged from 74% (sensitivity 92%) to 92% (sensitivity 94%).…”
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