Interpolymer Complexes of Water‐Soluble Nonionic Polysaccharides with Polycarboxylic Acids and Their Applications

Abstract

Literature data as well as our own experimental results devoted to the complexation of polycarboxylic acids with various water‐soluble polysaccharides (methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, starch, and dextran) by means of hydrogen bonding are systematized and analyzed. The specific peculiarities of interpolymer complexes based on polysaccharides‐polycarboxylic acids are demonstrated. The perspectives for the application of these interpolymer complexes are considered. It was shown that these materials possess good biocompatibility and adhesive properties. The promising directions for further study of interpolymer complexes between polycarboxylic acids and nonionic polysaccharides as well as existing gaps in the knowledge in this field are pointed out.Formation of compact IPCs and hydrophilic interpolymer associates.magnified imageFormation of compact IPCs and hydrophilic interpolymer associates.

Characterisation of Blends Based on Hydroxyethylcellulose and Maleic Acid‐alt‐Methyl Vinyl Ether

“…Specific interactions have also been reported in blends between poly(acrylic acid) (PAA) and various water-soluble polysaccharides. [3,[10][11][12][13][14][15] Complete miscibility as a rule is attributed to the strong intermacromolecular hydrogen bonding between the component polymers. Studies on blends of water-soluble polysaccharides and carboxylic acid copolymers containing the groups, which are not able to form hydrogen bonds, are quite limited.…”

“…A similar hypothesis was previously used to interpret complexation of dextran and HPC with respect to PAA. [3] Indeed, HPC exhibits much a higher ability to interact with PAA via hydrogen bonding and hydrophobic interactions than dextran, which justifies the poorer ability of the latter polymer to form miscible blends with MA-VA.…”

Investigation of the Interpolymer Complex between Hydroxypropyl Cellulose and Maleic Acid‐Styrene Copolymer, 1

“…[12][13][14][15] Concerning the applications, such kinds of IPCs are welcome, for pharmaceutical purposes, due to their high biocompatibility and biodegradability (induced by the natural compound). [16] The natural compounds mostly used for such purposes are the polysaccharides and their derivatives. [17] Formation of IPCs due to H-bonds depends strongly on different factors like the nature of the polymers, pH and ionic strength of solution, polymer-solvent interactions and temperature.…”

Interpolymer complexes of poly(acrylic acid) nanogels with some non-ionic polymers in aqueous solutions

“…Comprehensive information about formation of IPC, their physico-chemical properties, and some possible applications is presented in several review papers [1][2][3][4][5]. In most of the studies these complexes were obtained by mixing of linear macromolecules in a common solvent or by matrix polymerisation.…”